Eales’ Disease: When the Rare Sounds Frequent
Eales’ disease is a peripheral occlusive retinal phlebitis, with an unclear pathogenesis. The classic association with hypersensitivity to Mycobacterium tuberculosis protein infers that immunologic disturbance may be involved. Here, we described three cases of Eales’ disease. All patients are Caucas...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Ophthalmological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2021/1056659 |
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| author | Beatriz Oliveira Lopes Margarida Sena Brízido Ana Isabel Reis Margarida Maria Miranda Susana Morais Pina |
| author_facet | Beatriz Oliveira Lopes Margarida Sena Brízido Ana Isabel Reis Margarida Maria Miranda Susana Morais Pina |
| author_sort | Beatriz Oliveira Lopes |
| collection | DOAJ |
| description | Eales’ disease is a peripheral occlusive retinal phlebitis, with an unclear pathogenesis. The classic association with hypersensitivity to Mycobacterium tuberculosis protein infers that immunologic disturbance may be involved. Here, we described three cases of Eales’ disease. All patients are Caucasian men aged 27-58 years and presented with vitreous hemorrhage and/or peripheral venous vasculitis. Tuberculin skin sensitive test (Mantoux screening test) and interferon-gamma release assay (IGRA) were positive in all patients. Therapeutic approach included antituberculosis therapy and systemic steroids, associated or not to immunosuppressive therapy, and retinal scatter photocoagulation in all cases. Antivascular endothelial grow factor (VEGF) intravitreal injections were also required in two cases. Since various retinal diseases can resemble this presentation, Eales’ disease is considered a diagnosis of exclusion. Early diagnosis and appropriate therapeutic approach are both essential to accomplish disease control and reduce ophthalmologic complications. |
| format | Article |
| id | doaj-art-cf119dbd172849829009708b50ef1742 |
| institution | Kabale University |
| issn | 2090-6722 2090-6730 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Ophthalmological Medicine |
| spelling | doaj-art-cf119dbd172849829009708b50ef17422025-02-03T05:44:44ZengWileyCase Reports in Ophthalmological Medicine2090-67222090-67302021-01-01202110.1155/2021/10566591056659Eales’ Disease: When the Rare Sounds FrequentBeatriz Oliveira Lopes0Margarida Sena Brízido1Ana Isabel Reis2Margarida Maria Miranda3Susana Morais Pina4Department of Ophthalmology, Beatriz Ângelo Hospital, Loures, PortugalDepartment of Ophthalmology, Beatriz Ângelo Hospital, Loures, PortugalDepartment of Medicine, Beatriz Ângelo Hospital, Loures, PortugalDepartment of Ophthalmology, Beatriz Ângelo Hospital, Loures, PortugalDepartment of Ophthalmology, Beatriz Ângelo Hospital, Loures, PortugalEales’ disease is a peripheral occlusive retinal phlebitis, with an unclear pathogenesis. The classic association with hypersensitivity to Mycobacterium tuberculosis protein infers that immunologic disturbance may be involved. Here, we described three cases of Eales’ disease. All patients are Caucasian men aged 27-58 years and presented with vitreous hemorrhage and/or peripheral venous vasculitis. Tuberculin skin sensitive test (Mantoux screening test) and interferon-gamma release assay (IGRA) were positive in all patients. Therapeutic approach included antituberculosis therapy and systemic steroids, associated or not to immunosuppressive therapy, and retinal scatter photocoagulation in all cases. Antivascular endothelial grow factor (VEGF) intravitreal injections were also required in two cases. Since various retinal diseases can resemble this presentation, Eales’ disease is considered a diagnosis of exclusion. Early diagnosis and appropriate therapeutic approach are both essential to accomplish disease control and reduce ophthalmologic complications.http://dx.doi.org/10.1155/2021/1056659 |
| spellingShingle | Beatriz Oliveira Lopes Margarida Sena Brízido Ana Isabel Reis Margarida Maria Miranda Susana Morais Pina Eales’ Disease: When the Rare Sounds Frequent Case Reports in Ophthalmological Medicine |
| title | Eales’ Disease: When the Rare Sounds Frequent |
| title_full | Eales’ Disease: When the Rare Sounds Frequent |
| title_fullStr | Eales’ Disease: When the Rare Sounds Frequent |
| title_full_unstemmed | Eales’ Disease: When the Rare Sounds Frequent |
| title_short | Eales’ Disease: When the Rare Sounds Frequent |
| title_sort | eales disease when the rare sounds frequent |
| url | http://dx.doi.org/10.1155/2021/1056659 |
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