Unveiling the therapeutic role of penfluridol and BMS-754,807: NUDT5 inhibition in breast cancer

Unveiling the therapeutic role of penfluridol and BMS-754,807: NUDT5 inhibition in breast cancer

Breast cancer (BC) remains a leading cause of cancer-related mortality among women, with hormone-receptor-positive subtypes frequently developing resistance to standard therapies. Nudix hydrolase 5 (NUDT5), an enzyme integral to ADP-ribose metabolism, DNA repair, and hormone-driven transcription, ha...

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Bibliographic Details
Main Authors: Majed S. AlFayi, Mohd Saeed, Irfan Ahmad, Mohd Adnan Kausar, Samra Siddiqui, Saba Irem, Faisal Fawaz Alshammari, Riadh Badraoui, Dharmendra Kumar Yadav
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Chemical Physics Impact
Subjects:
Breast Cancer
NUDT5
MD simulation
PCA
FEL
Online Access:http://www.sciencedirect.com/science/article/pii/S2667022425000593
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