ROLE OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN ADULT PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA
Adult acute lymphoblastic leukemia (ALL) is a heterogeneous disease, due to the expression of different biological and clinical risk factors, for which allogeneic stem cell transplantation (alloHSCT) is an effective consolidation therapy. The non-relapse mortality of alloHSCT remains significantly h...
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| Format: | Article |
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PAGEPress Publications
2014-10-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/2035 |
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| author | Federico Lussana Alessandro Rambaldi |
| author_facet | Federico Lussana Alessandro Rambaldi |
| author_sort | Federico Lussana |
| collection | DOAJ |
| description | Adult acute lymphoblastic leukemia (ALL) is a heterogeneous disease, due to the expression of different biological and clinical risk factors, for which allogeneic stem cell transplantation (alloHSCT) is an effective consolidation therapy. The non-relapse mortality of alloHSCT remains significantly higher compared with that of conventional chemotherapy; therefore, one of the main challenges in the care of ALL is to establish a more precise prognostic definition to select patients who could take advantage from an alloHSCT. Currently, the use of minimal residual disease following induction and early consolidation therapy has improved the prognostic accuracy in defining ALL risk class. In Philadelphia-positive ALL, the introduction of tyrosine kinase inhibitors pre and post alloHSCT appears to improve outcomes significantly and, in the absence of specifically designed clinical trials, alloHSCT remains the most effective post- remission therapy. Nowadays, alloHSCT can be performed according to different modalities encompassing the use of different conditioning regimens, as well as different donors and stem cell source, with a significant accessibility to transplant. |
| format | Article |
| id | doaj-art-cf0e43fa3dbd49ebbf5056cb97410eac |
| institution | OA Journals |
| issn | 2035-3006 |
| language | English |
| publishDate | 2014-10-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-cf0e43fa3dbd49ebbf5056cb97410eac2025-08-20T01:47:47ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062014-10-0161e2014065e201406510.4084/mjhid.2014.0651491ROLE OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN ADULT PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIAFederico Lussana0Alessandro Rambaldi1Hematology and Bone Marrow Transplant Unit A.O. Ospedale Papa Giovanni XXIII Bergamo Piazza OMS, 1 24127 Bergamo ITALYHematology and Bone Marrow Transplant Unit A.O. Ospedale Papa Giovanni XXIII Bergamo Piazza OMS, 1 24127 Bergamo ITALYAdult acute lymphoblastic leukemia (ALL) is a heterogeneous disease, due to the expression of different biological and clinical risk factors, for which allogeneic stem cell transplantation (alloHSCT) is an effective consolidation therapy. The non-relapse mortality of alloHSCT remains significantly higher compared with that of conventional chemotherapy; therefore, one of the main challenges in the care of ALL is to establish a more precise prognostic definition to select patients who could take advantage from an alloHSCT. Currently, the use of minimal residual disease following induction and early consolidation therapy has improved the prognostic accuracy in defining ALL risk class. In Philadelphia-positive ALL, the introduction of tyrosine kinase inhibitors pre and post alloHSCT appears to improve outcomes significantly and, in the absence of specifically designed clinical trials, alloHSCT remains the most effective post- remission therapy. Nowadays, alloHSCT can be performed according to different modalities encompassing the use of different conditioning regimens, as well as different donors and stem cell source, with a significant accessibility to transplant.http://www.mjhid.org/index.php/mjhid/article/view/2035Acute Lymphoblastic LeukemiaAllogeneic Bone Marrow Transplantation |
| spellingShingle | Federico Lussana Alessandro Rambaldi ROLE OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN ADULT PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA Mediterranean Journal of Hematology and Infectious Diseases Acute Lymphoblastic Leukemia Allogeneic Bone Marrow Transplantation |
| title | ROLE OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN ADULT PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA |
| title_full | ROLE OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN ADULT PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA |
| title_fullStr | ROLE OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN ADULT PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA |
| title_full_unstemmed | ROLE OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN ADULT PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA |
| title_short | ROLE OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN ADULT PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA |
| title_sort | role of allogeneic hematopoietic stem cell transplantation in adult patients with acute lymphoblastic leukemia |
| topic | Acute Lymphoblastic Leukemia Allogeneic Bone Marrow Transplantation |
| url | http://www.mjhid.org/index.php/mjhid/article/view/2035 |
| work_keys_str_mv | AT federicolussana roleofallogeneichematopoieticstemcelltransplantationinadultpatientswithacutelymphoblasticleukemia AT alessandrorambaldi roleofallogeneichematopoieticstemcelltransplantationinadultpatientswithacutelymphoblasticleukemia |