Preoperative metronidazole treatment to evaluate its efficacy in reducing Fusobacterium nucleatum colonisation in colorectal cancer patients: a proof-of-concept trial

Preoperative metronidazole treatment to evaluate its efficacy in reducing Fusobacterium nucleatum colonisation in colorectal cancer patients: a proof-of-concept trial

Background: Colorectal cancer (CRC) is one of the most prevalent tumour types and a leading cause of cancer-related mortality worldwide. Surgery represents the primary therapeutic option, while advanced cases are typically managed with established chemotherapy protocols, which exhibit variable respo...

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Bibliographic Details
Main Authors: S. De Dosso, D. Christoforidis, E. Merlo, A. Vannelli, S. Popeskou, P. Gaffuri, G. Lollo, L. Ambrosiani, F. Radaelli, M. Frattini, M. Marengo, K. Galetti, G. Iezzi
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:ESMO Gastrointestinal Oncology
Subjects:
colon cancer
Fusobacterium nucleatum
metronidazole
microbiota
Online Access:http://www.sciencedirect.com/science/article/pii/S294981982500038X
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