Impact of elevated sclerostin levels on bone resorption: unravelling structural changes and mineral metabolism disruption

Impact of elevated sclerostin levels on bone resorption: unravelling structural changes and mineral metabolism disruption

Aims: The physiological function of sclerostin remains unknown. Sclerostin is synthesized by osteocytes and operates by inhibiting the Wnt/β-catenin pathway. Similarly, it is well established that low levels of sclerostin lead to enhanced bone formation and reduced calciuria, and that high levels o...

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Main Authors: María Encarnacion Rodríguez-Ortiz, Juan Miguel Díaz-Tocados, Ana Isabel Torralbo, Karen Valdés-Díaz, Antonio Rivas-Domínguez, Fátima Guerrero, Irene Reina-Alfonso, Manuel Naves-Díaz, Cristina Alonso-Montes, Cristian Rodelo-Haad, Mariano Rodríguez, Juan Rafael Muñoz-Castañeda, IMIBIC Nephrology Group
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2025-05-01
Series:Bone & Joint Research
Subjects:
sclerostin
bone resorption
bone turnover
mineral metabolism
trap activity
rat model
trap-staining
osteoclasts
cortical bone
trabecular bone
chondrocytes
calcium
growth plate
osteocytes
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.145.BJR-2024-0227.R1
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