Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy
The aims of this study were to compare circulating cytokines between FM and healthy controls and to investigate the effect on cytokine levels by 15 weeks of progressive resistance exercise or relaxation therapy in FM. Baseline plasma cytokine levels and clinical data were analyzed in 125 women with...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/3985154 |
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| author | M. Ernberg N. Christidis B. Ghafouri I. Bileviciute-Ljungar M. Löfgren J. Bjersing A. Palstam A. Larsson K. Mannerkorpi B. Gerdle E. Kosek |
| author_facet | M. Ernberg N. Christidis B. Ghafouri I. Bileviciute-Ljungar M. Löfgren J. Bjersing A. Palstam A. Larsson K. Mannerkorpi B. Gerdle E. Kosek |
| author_sort | M. Ernberg |
| collection | DOAJ |
| description | The aims of this study were to compare circulating cytokines between FM and healthy controls and to investigate the effect on cytokine levels by 15 weeks of progressive resistance exercise or relaxation therapy in FM. Baseline plasma cytokine levels and clinical data were analyzed in 125 women with FM and 130 age-matched healthy women. The FM women were then randomized to progressive resistance exercise (n=49) or relaxation (n=43). Baseline IL-2, IL-6, TNF-α, IP-10, and eotaxin were higher in FM than in healthy controls (P<0.041), whereas IL-1β was lower (P<0.001). There were weak correlations between cytokine levels and clinical variables. After both interventions, IL-1ra had increased (P=0.004), while IL-1β had increased in the relaxation group (P=0.002). Changes of IFN-γ, IL-2, IL-4, IL-6, IL-8, and IL-17A were weakly correlated with changes of PPT, but there were no significant correlations between changes of cytokine and changes in other clinical variables. The elevated plasma levels of several cytokines supports the hypothesis that chronic systemic inflammation may underlie the pathophysiology of FM even if the relation to clinical variables was weak. However, 15 weeks of resistance exercise, as performed in this study, did not show any anti-inflammatory effect on neither FM symptoms nor clinical and functional variables. This trial is registered with ClinicalTrials.govNCT01226784, registered October 21, 2010. The first patient was recruited October 28, 2010. |
| format | Article |
| id | doaj-art-cf0161741f2d4d74a230eedd145475a1 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-cf0161741f2d4d74a230eedd145475a12025-08-20T02:19:30ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/39851543985154Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation TherapyM. Ernberg0N. Christidis1B. Ghafouri2I. Bileviciute-Ljungar3M. Löfgren4J. Bjersing5A. Palstam6A. Larsson7K. Mannerkorpi8B. Gerdle9E. Kosek10Department of Dental Medicine, Karolinska Institutet and Scandinavian Center for Orofacial Neurosciences (SCON), 141 04 Huddinge, SwedenDepartment of Dental Medicine, Karolinska Institutet and Scandinavian Center for Orofacial Neurosciences (SCON), 141 04 Huddinge, SwedenPain and Rehabilitation Centre and Department of Medical and Health Sciences, Linköping University, 581 85 Linköping, SwedenDepartment of Clinical Sciences, Karolinska Institutet and Department of Rehabilitation Medicine, Danderyd Hospital, 182 88 Stockholm, SwedenDepartment of Clinical Sciences, Karolinska Institutet and Department of Rehabilitation Medicine, Danderyd Hospital, 182 88 Stockholm, SwedenDepartment of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Göteborg, SwedenInstitute of Neuroscience and Physiology, Section of Health and Rehabilitation, Physiotherapy, Sahlgrenska Academy, University of Gothenburg, 405 30 Göteborg, SwedenInstitute of Neuroscience and Physiology, Section of Health and Rehabilitation, Physiotherapy, Sahlgrenska Academy, University of Gothenburg, 405 30 Göteborg, SwedenInstitute of Neuroscience and Physiology, Section of Health and Rehabilitation, Physiotherapy, Sahlgrenska Academy, University of Gothenburg, 405 30 Göteborg, SwedenPain and Rehabilitation Centre and Department of Medical and Health Sciences, Linköping University, 581 85 Linköping, SwedenDepartment of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, SwedenThe aims of this study were to compare circulating cytokines between FM and healthy controls and to investigate the effect on cytokine levels by 15 weeks of progressive resistance exercise or relaxation therapy in FM. Baseline plasma cytokine levels and clinical data were analyzed in 125 women with FM and 130 age-matched healthy women. The FM women were then randomized to progressive resistance exercise (n=49) or relaxation (n=43). Baseline IL-2, IL-6, TNF-α, IP-10, and eotaxin were higher in FM than in healthy controls (P<0.041), whereas IL-1β was lower (P<0.001). There were weak correlations between cytokine levels and clinical variables. After both interventions, IL-1ra had increased (P=0.004), while IL-1β had increased in the relaxation group (P=0.002). Changes of IFN-γ, IL-2, IL-4, IL-6, IL-8, and IL-17A were weakly correlated with changes of PPT, but there were no significant correlations between changes of cytokine and changes in other clinical variables. The elevated plasma levels of several cytokines supports the hypothesis that chronic systemic inflammation may underlie the pathophysiology of FM even if the relation to clinical variables was weak. However, 15 weeks of resistance exercise, as performed in this study, did not show any anti-inflammatory effect on neither FM symptoms nor clinical and functional variables. This trial is registered with ClinicalTrials.govNCT01226784, registered October 21, 2010. The first patient was recruited October 28, 2010.http://dx.doi.org/10.1155/2018/3985154 |
| spellingShingle | M. Ernberg N. Christidis B. Ghafouri I. Bileviciute-Ljungar M. Löfgren J. Bjersing A. Palstam A. Larsson K. Mannerkorpi B. Gerdle E. Kosek Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy Mediators of Inflammation |
| title | Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy |
| title_full | Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy |
| title_fullStr | Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy |
| title_full_unstemmed | Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy |
| title_short | Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy |
| title_sort | plasma cytokine levels in fibromyalgia and their response to 15 weeks of progressive resistance exercise or relaxation therapy |
| url | http://dx.doi.org/10.1155/2018/3985154 |
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