Using a brain-like endothelial cell differentiation to characterize the CS79iBRCA-n2 BRCA1 mutated patient derived stem cell line

Using a brain-like endothelial cell differentiation to characterize the CS79iBRCA-n2 BRCA1 mutated patient derived stem cell line

BRCA1/2 genes are considered tumor suppressor genes and help repair damaged DNA. Pathogenic germline mutations of BRCA1/2 genes are the most common hereditary cause of breast cancer and ovarian cancer. It has been established that BRCA1 mutations increase the risk of brain metastasis compared to the...

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Bibliographic Details
Main Authors: Natalie G. Alexander, Kylie A. Buchanan, Alexandra E. Meyer, Lauren M. Mitterway, Caroline O. Vanderburgh, Shreyas S. Rao, Brandon J. Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
blood-brain barrier
patient derived stem cells
BRCA1 mutation
brain endothelial cells
induced pluripotent stem cells
disease modeling
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1516669/full
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