tRNA/mRNA Mimicry by tmRNA and SmpB in Trans-Translation
Since accurate translation from mRNA to protein is critical to survival, cells have developed translational quality control systems. Bacterial ribosomes stalled on truncated mRNA are rescued by a system involving tmRNA and SmpB referred to as trans-translation. Here, we review current understanding...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Nucleic Acids |
| Online Access: | http://dx.doi.org/10.4061/2011/130581 |
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| _version_ | 1832548570811596800 |
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| author | Daisuke Kurita Akira Muto Hyouta Himeno |
| author_facet | Daisuke Kurita Akira Muto Hyouta Himeno |
| author_sort | Daisuke Kurita |
| collection | DOAJ |
| description | Since accurate translation from mRNA to protein is critical to survival, cells have developed translational quality control systems. Bacterial ribosomes stalled on truncated mRNA are rescued by a system involving tmRNA and SmpB referred to as trans-translation. Here, we review current understanding of the mechanism of trans-translation. Based on results obtained by using directed hydroxyl radical probing, we propose a new type of molecular mimicry during trans-translation. Besides such chemical approaches, biochemical and cryo-EM studies have revealed the structural and functional aspects of multiple stages of trans-translation. These intensive works provide a basis for studying the dynamics of tmRNA/SmpB in the ribosome. |
| format | Article |
| id | doaj-art-ceed8a3f47424fe89e63c4bc65868423 |
| institution | Kabale University |
| issn | 2090-021X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nucleic Acids |
| spelling | doaj-art-ceed8a3f47424fe89e63c4bc658684232025-02-03T06:13:51ZengWileyJournal of Nucleic Acids2090-021X2011-01-01201110.4061/2011/130581130581tRNA/mRNA Mimicry by tmRNA and SmpB in Trans-TranslationDaisuke Kurita0Akira Muto1Hyouta Himeno2Department of Biochemistry and Molecular Biology, Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki 036-8561, JapanDepartment of Biochemistry and Molecular Biology, Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki 036-8561, JapanDepartment of Biochemistry and Molecular Biology, Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki 036-8561, JapanSince accurate translation from mRNA to protein is critical to survival, cells have developed translational quality control systems. Bacterial ribosomes stalled on truncated mRNA are rescued by a system involving tmRNA and SmpB referred to as trans-translation. Here, we review current understanding of the mechanism of trans-translation. Based on results obtained by using directed hydroxyl radical probing, we propose a new type of molecular mimicry during trans-translation. Besides such chemical approaches, biochemical and cryo-EM studies have revealed the structural and functional aspects of multiple stages of trans-translation. These intensive works provide a basis for studying the dynamics of tmRNA/SmpB in the ribosome.http://dx.doi.org/10.4061/2011/130581 |
| spellingShingle | Daisuke Kurita Akira Muto Hyouta Himeno tRNA/mRNA Mimicry by tmRNA and SmpB in Trans-Translation Journal of Nucleic Acids |
| title | tRNA/mRNA Mimicry by tmRNA and SmpB in Trans-Translation |
| title_full | tRNA/mRNA Mimicry by tmRNA and SmpB in Trans-Translation |
| title_fullStr | tRNA/mRNA Mimicry by tmRNA and SmpB in Trans-Translation |
| title_full_unstemmed | tRNA/mRNA Mimicry by tmRNA and SmpB in Trans-Translation |
| title_short | tRNA/mRNA Mimicry by tmRNA and SmpB in Trans-Translation |
| title_sort | trna mrna mimicry by tmrna and smpb in trans translation |
| url | http://dx.doi.org/10.4061/2011/130581 |
| work_keys_str_mv | AT daisukekurita trnamrnamimicrybytmrnaandsmpbintranstranslation AT akiramuto trnamrnamimicrybytmrnaandsmpbintranstranslation AT hyoutahimeno trnamrnamimicrybytmrnaandsmpbintranstranslation |