Therapeutic Potentials of Silver Nanoparticle Complex of α-Lipoic Acid
Silver (SN) nanoparticles were re‐dispersed in aqueous solution of Pluronic F127 and complexed with the antioxidant, alpha‐ Lipoic acid (LA). The nanoparticle ‐ LA complex (SN‐LA) was characterized using SEM. SN‐ LA exhibited DPPH radical scavenging...
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| Format: | Article |
| Language: | English |
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Wiley
2011-10-01
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| Series: | Nanomaterials and Nanotechnology |
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| Online Access: | http://www.intechopen.com/journals/nanomaterials_and_nanotechnology/therapeutic_potentials_of_silver_nanoparticle_complex_of_945_lipoic_acid |
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| author | Lakshmy Ramachandran Cherupally Krishnan Krishnan Nair |
| author_facet | Lakshmy Ramachandran Cherupally Krishnan Krishnan Nair |
| author_sort | Lakshmy Ramachandran |
| collection | DOAJ |
| description | Silver (SN) nanoparticles were re‐dispersed in aqueous solution of Pluronic F127 and complexed with the antioxidant, alpha‐ Lipoic acid (LA). The nanoparticle ‐ LA complex (SN‐LA) was characterized using SEM. SN‐ LA exhibited DPPH radical scavenging activity in vitro and anti‐ inflammatory activity against acute and chronic paw models of edema in mice. SN‐LA protected mice from whole body gamma radiation induced body weight losses and mortality revealing its radioprotecting capacity. Meanwhile, SN‐LA administration to tumour‐ bearing mice prior to whole body gamma radiation exposure, aided in better tumour growth delay. The results suggest the feasibility in using SN‐LA as a therapeutic adjuvant during cancer radiotherapy. |
| format | Article |
| id | doaj-art-ceecff3813df410aa1f5dd85d75a37cd |
| institution | Kabale University |
| issn | 1847-9804 |
| language | English |
| publishDate | 2011-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Nanomaterials and Nanotechnology |
| spelling | doaj-art-ceecff3813df410aa1f5dd85d75a37cd2025-02-03T06:42:54ZengWileyNanomaterials and Nanotechnology1847-98042011-10-0112http://dx.doi.org/10.5772/50956Therapeutic Potentials of Silver Nanoparticle Complex of α-Lipoic AcidLakshmy RamachandranCherupally Krishnan Krishnan NairSilver (SN) nanoparticles were re‐dispersed in aqueous solution of Pluronic F127 and complexed with the antioxidant, alpha‐ Lipoic acid (LA). The nanoparticle ‐ LA complex (SN‐LA) was characterized using SEM. SN‐ LA exhibited DPPH radical scavenging activity in vitro and anti‐ inflammatory activity against acute and chronic paw models of edema in mice. SN‐LA protected mice from whole body gamma radiation induced body weight losses and mortality revealing its radioprotecting capacity. Meanwhile, SN‐LA administration to tumour‐ bearing mice prior to whole body gamma radiation exposure, aided in better tumour growth delay. The results suggest the feasibility in using SN‐LA as a therapeutic adjuvant during cancer radiotherapy.http://www.intechopen.com/journals/nanomaterials_and_nanotechnology/therapeutic_potentials_of_silver_nanoparticle_complex_of_945_lipoic_acid silver nanoparticlelipoic acidanti‐inflammatoryanti tumorradiotherapy |
| spellingShingle | Lakshmy Ramachandran Cherupally Krishnan Krishnan Nair Therapeutic Potentials of Silver Nanoparticle Complex of α-Lipoic Acid Nanomaterials and Nanotechnology silver nanoparticle lipoic acid anti‐ inflammatory anti tumor radiotherapy |
| title | Therapeutic Potentials of Silver Nanoparticle Complex of α-Lipoic Acid |
| title_full | Therapeutic Potentials of Silver Nanoparticle Complex of α-Lipoic Acid |
| title_fullStr | Therapeutic Potentials of Silver Nanoparticle Complex of α-Lipoic Acid |
| title_full_unstemmed | Therapeutic Potentials of Silver Nanoparticle Complex of α-Lipoic Acid |
| title_short | Therapeutic Potentials of Silver Nanoparticle Complex of α-Lipoic Acid |
| title_sort | therapeutic potentials of silver nanoparticle complex of 945 lipoic acid |
| topic | silver nanoparticle lipoic acid anti‐ inflammatory anti tumor radiotherapy |
| url | http://www.intechopen.com/journals/nanomaterials_and_nanotechnology/therapeutic_potentials_of_silver_nanoparticle_complex_of_945_lipoic_acid |
| work_keys_str_mv | AT lakshmyramachandran therapeuticpotentialsofsilvernanoparticlecomplexof945lipoicacid AT cherupallykrishnankrishnannair therapeuticpotentialsofsilvernanoparticlecomplexof945lipoicacid |