Prognostic value of elevated postoperative high-sensitivity troponin T in diabetes mellitus patients for ischemic events within 12 months after PCI in ACS patients: a retrospective cohort study
ObjectiveThis study aimed to investigate the prognostic value of high-sensitivity cardiac troponin T (hs-cTnT) levels and diabetes mellitus (DM) on ischemic events within 12 months after percutaneous coronary intervention (PCI) in acute coronary syndrome(ACS) patients.MethodsThis retrospective cohor...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1606435/full |
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| author | Xuefei Mu Miaohan Qiu Shangxun Zhou Shangxun Zhou Yixuan Duan Yixuan Duan Daoshen Liu Daoshen Liu Kai Xu Quanmin Jing Yi Li Yaling Han |
| author_facet | Xuefei Mu Miaohan Qiu Shangxun Zhou Shangxun Zhou Yixuan Duan Yixuan Duan Daoshen Liu Daoshen Liu Kai Xu Quanmin Jing Yi Li Yaling Han |
| author_sort | Xuefei Mu |
| collection | DOAJ |
| description | ObjectiveThis study aimed to investigate the prognostic value of high-sensitivity cardiac troponin T (hs-cTnT) levels and diabetes mellitus (DM) on ischemic events within 12 months after percutaneous coronary intervention (PCI) in acute coronary syndrome(ACS) patients.MethodsThis retrospective cohort study included 14,173 consecutive ACS patients undergoing PCI at the General Hospital of the Northern Theater Command between March 2016 and March 2022. The primary outcome was the occurrence of ischemic events within 12 months, defined as a composite of cardiac death, non-fatal myocardial infarction (MI), and/or stroke. Secondary outcomes included all-cause mortality at 12 months and the individual components of the primary outcome.ResultsDuring the 12-month follow-up, the overall incidence rates of ischemic events, cardiac death, MI, stroke, and all-cause mortality were 2.19%, 1.12%, 0.58%, 0.59%, and 1.55%, respectively. Elevated hs-cTnT levels were significantly associated with increased risks of ischemic events (adjusted HR: 1.91, 95% CI: 1.19–3.09), cardiac death (adjusted HR: 2.00, 95% CI: 1.08–3.71), and all-cause mortality (adjusted HR: 2.78, 95% CI: 1.62–4.76). In diabetic patients, the risks were particularly pronounced when hs-cTnT levels reached ≥5 × URL. Interaction analyses showed no significant interaction between hs-cTnT levels and diabetes status regarding ischemic events (P = 0.78), but a significant interaction for all-cause mortality (P = 0.01).ConclusionsElevated hs-cTnT levels and the presence of DM are independently associated with an increased risks of ischemic events and all-cause mortality after PCI in ACS patients. The impact of hs-cTnT on mortality is more pronounced in diabetic patients. |
| format | Article |
| id | doaj-art-cee817c02e7e423fbe993fc503f78c64 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-cee817c02e7e423fbe993fc503f78c642025-08-20T03:24:44ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-06-011210.3389/fcvm.2025.16064351606435Prognostic value of elevated postoperative high-sensitivity troponin T in diabetes mellitus patients for ischemic events within 12 months after PCI in ACS patients: a retrospective cohort studyXuefei Mu0Miaohan Qiu1Shangxun Zhou2Shangxun Zhou3Yixuan Duan4Yixuan Duan5Daoshen Liu6Daoshen Liu7Kai Xu8Quanmin Jing9Yi Li10Yaling Han11State Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research Institute and Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, ChinaState Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research Institute and Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, ChinaState Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research Institute and Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, ChinaThe Department of Cardiology, Xijing Hospital, Air Force Medical University, Xi'an, ChinaState Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research Institute and Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, ChinaThe Department of Cardiology, Xijing Hospital, Air Force Medical University, Xi'an, ChinaState Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research Institute and Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, ChinaThe Department of Cardiology, Xijing Hospital, Air Force Medical University, Xi'an, ChinaState Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research Institute and Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, ChinaState Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research Institute and Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, ChinaState Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research Institute and Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, ChinaState Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research Institute and Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, ChinaObjectiveThis study aimed to investigate the prognostic value of high-sensitivity cardiac troponin T (hs-cTnT) levels and diabetes mellitus (DM) on ischemic events within 12 months after percutaneous coronary intervention (PCI) in acute coronary syndrome(ACS) patients.MethodsThis retrospective cohort study included 14,173 consecutive ACS patients undergoing PCI at the General Hospital of the Northern Theater Command between March 2016 and March 2022. The primary outcome was the occurrence of ischemic events within 12 months, defined as a composite of cardiac death, non-fatal myocardial infarction (MI), and/or stroke. Secondary outcomes included all-cause mortality at 12 months and the individual components of the primary outcome.ResultsDuring the 12-month follow-up, the overall incidence rates of ischemic events, cardiac death, MI, stroke, and all-cause mortality were 2.19%, 1.12%, 0.58%, 0.59%, and 1.55%, respectively. Elevated hs-cTnT levels were significantly associated with increased risks of ischemic events (adjusted HR: 1.91, 95% CI: 1.19–3.09), cardiac death (adjusted HR: 2.00, 95% CI: 1.08–3.71), and all-cause mortality (adjusted HR: 2.78, 95% CI: 1.62–4.76). In diabetic patients, the risks were particularly pronounced when hs-cTnT levels reached ≥5 × URL. Interaction analyses showed no significant interaction between hs-cTnT levels and diabetes status regarding ischemic events (P = 0.78), but a significant interaction for all-cause mortality (P = 0.01).ConclusionsElevated hs-cTnT levels and the presence of DM are independently associated with an increased risks of ischemic events and all-cause mortality after PCI in ACS patients. The impact of hs-cTnT on mortality is more pronounced in diabetic patients.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1606435/fullacute coronary syndromepercutaneous coronary interventionhigh-sensitivity cardiac troponin Tdiabetes mellitusischemic events |
| spellingShingle | Xuefei Mu Miaohan Qiu Shangxun Zhou Shangxun Zhou Yixuan Duan Yixuan Duan Daoshen Liu Daoshen Liu Kai Xu Quanmin Jing Yi Li Yaling Han Prognostic value of elevated postoperative high-sensitivity troponin T in diabetes mellitus patients for ischemic events within 12 months after PCI in ACS patients: a retrospective cohort study Frontiers in Cardiovascular Medicine acute coronary syndrome percutaneous coronary intervention high-sensitivity cardiac troponin T diabetes mellitus ischemic events |
| title | Prognostic value of elevated postoperative high-sensitivity troponin T in diabetes mellitus patients for ischemic events within 12 months after PCI in ACS patients: a retrospective cohort study |
| title_full | Prognostic value of elevated postoperative high-sensitivity troponin T in diabetes mellitus patients for ischemic events within 12 months after PCI in ACS patients: a retrospective cohort study |
| title_fullStr | Prognostic value of elevated postoperative high-sensitivity troponin T in diabetes mellitus patients for ischemic events within 12 months after PCI in ACS patients: a retrospective cohort study |
| title_full_unstemmed | Prognostic value of elevated postoperative high-sensitivity troponin T in diabetes mellitus patients for ischemic events within 12 months after PCI in ACS patients: a retrospective cohort study |
| title_short | Prognostic value of elevated postoperative high-sensitivity troponin T in diabetes mellitus patients for ischemic events within 12 months after PCI in ACS patients: a retrospective cohort study |
| title_sort | prognostic value of elevated postoperative high sensitivity troponin t in diabetes mellitus patients for ischemic events within 12 months after pci in acs patients a retrospective cohort study |
| topic | acute coronary syndrome percutaneous coronary intervention high-sensitivity cardiac troponin T diabetes mellitus ischemic events |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1606435/full |
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