Hydrogels from Protein–Polymer Conjugates: A Pathway to Next-Generation Biomaterials
Hybrid hydrogels from protein–polymer conjugates are biomaterials formed via the chemical bonding of a protein molecule with a polymer molecule. Protein–polymer conjugates offer a variety of biological properties by combining the mechanical strength of polymers and the bioactive functionality of pro...
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| Format: | Article |
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MDPI AG
2025-01-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/11/2/96 |
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| author | Oubadah Alayoubi Yağmur Poyraz Gana Hassan Sümeyye Berfin Gül Nergiz Çalhan Naz Mina Mert Şahin Megha Gautam Aylin Kutlu Bengü Özuğur Uysal Ebru Demet Akten Önder Pekcan |
| author_facet | Oubadah Alayoubi Yağmur Poyraz Gana Hassan Sümeyye Berfin Gül Nergiz Çalhan Naz Mina Mert Şahin Megha Gautam Aylin Kutlu Bengü Özuğur Uysal Ebru Demet Akten Önder Pekcan |
| author_sort | Oubadah Alayoubi |
| collection | DOAJ |
| description | Hybrid hydrogels from protein–polymer conjugates are biomaterials formed via the chemical bonding of a protein molecule with a polymer molecule. Protein–polymer conjugates offer a variety of biological properties by combining the mechanical strength of polymers and the bioactive functionality of proteins. These properties allow these conjugates to be used as biocompatible components in biomedical applications. Protein–polymer conjugation is a vital bioengineering strategy in many fields, such as drug delivery, tissue engineering, and cancer therapy. Protein–polymer conjugations aim to create materials with new and unique properties by combining the properties of different molecular components. There are various ways of creating protein–polymer conjugates. PEGylation is one of the most common conjugation techniques where a protein is conjugated with Polyethylene Glycol. However, some limitations of PEGylation (like polydispersity and low biodegradability) have prompted researchers to devise novel synthesis techniques like PEGylation, where synthetic polypeptides are used as the polymer component. This review will illustrate the properties of protein–polymer conjugates, their synthesis methods, and their various biomedical applications. |
| format | Article |
| id | doaj-art-cee6615b521742a789fdae27b8e2cbef |
| institution | DOAJ |
| issn | 2310-2861 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj-art-cee6615b521742a789fdae27b8e2cbef2025-08-20T03:12:05ZengMDPI AGGels2310-28612025-01-011129610.3390/gels11020096Hydrogels from Protein–Polymer Conjugates: A Pathway to Next-Generation BiomaterialsOubadah Alayoubi0Yağmur Poyraz1Gana Hassan2Sümeyye Berfin Gül3Nergiz Çalhan4Naz Mina Mert Şahin5Megha Gautam6Aylin Kutlu7Bengü Özuğur Uysal8Ebru Demet Akten9Önder Pekcan10Materials Science and Nanotechnology, School of Graduate Studies, Kadir Has University, Cibali, Fatih, Istanbul 34083, TürkiyeComputational Sciences and Engineering, School of Graduate Studies, Kadir Has University, Cibali, Fatih, Istanbul 34083, TürkiyeMaterials Science and Nanotechnology, School of Graduate Studies, Kadir Has University, Cibali, Fatih, Istanbul 34083, TürkiyeMaterials Science and Nanotechnology, School of Graduate Studies, Kadir Has University, Cibali, Fatih, Istanbul 34083, TürkiyeMaterials Science and Nanotechnology, School of Graduate Studies, Kadir Has University, Cibali, Fatih, Istanbul 34083, TürkiyeComputational Sciences and Engineering, School of Graduate Studies, Kadir Has University, Cibali, Fatih, Istanbul 34083, TürkiyeComputational Sciences and Engineering, School of Graduate Studies, Kadir Has University, Cibali, Fatih, Istanbul 34083, TürkiyeMaterials Science and Nanotechnology, School of Graduate Studies, Kadir Has University, Cibali, Fatih, Istanbul 34083, TürkiyeDepartment of Basic Sciences, Faculty of Engineering and Architecture, Altınbaş University, Bağcılar, Istanbul 34218, TürkiyeFaculty of Engineering and Natural Sciences, Kadir Has University, Cibali, Fatih, Istanbul 34083, TürkiyeFaculty of Engineering and Natural Sciences, Kadir Has University, Cibali, Fatih, Istanbul 34083, TürkiyeHybrid hydrogels from protein–polymer conjugates are biomaterials formed via the chemical bonding of a protein molecule with a polymer molecule. Protein–polymer conjugates offer a variety of biological properties by combining the mechanical strength of polymers and the bioactive functionality of proteins. These properties allow these conjugates to be used as biocompatible components in biomedical applications. Protein–polymer conjugation is a vital bioengineering strategy in many fields, such as drug delivery, tissue engineering, and cancer therapy. Protein–polymer conjugations aim to create materials with new and unique properties by combining the properties of different molecular components. There are various ways of creating protein–polymer conjugates. PEGylation is one of the most common conjugation techniques where a protein is conjugated with Polyethylene Glycol. However, some limitations of PEGylation (like polydispersity and low biodegradability) have prompted researchers to devise novel synthesis techniques like PEGylation, where synthetic polypeptides are used as the polymer component. This review will illustrate the properties of protein–polymer conjugates, their synthesis methods, and their various biomedical applications.https://www.mdpi.com/2310-2861/11/2/96hybrid hydrogelsprotein–polymer conjugatesPEGylation |
| spellingShingle | Oubadah Alayoubi Yağmur Poyraz Gana Hassan Sümeyye Berfin Gül Nergiz Çalhan Naz Mina Mert Şahin Megha Gautam Aylin Kutlu Bengü Özuğur Uysal Ebru Demet Akten Önder Pekcan Hydrogels from Protein–Polymer Conjugates: A Pathway to Next-Generation Biomaterials Gels hybrid hydrogels protein–polymer conjugates PEGylation |
| title | Hydrogels from Protein–Polymer Conjugates: A Pathway to Next-Generation Biomaterials |
| title_full | Hydrogels from Protein–Polymer Conjugates: A Pathway to Next-Generation Biomaterials |
| title_fullStr | Hydrogels from Protein–Polymer Conjugates: A Pathway to Next-Generation Biomaterials |
| title_full_unstemmed | Hydrogels from Protein–Polymer Conjugates: A Pathway to Next-Generation Biomaterials |
| title_short | Hydrogels from Protein–Polymer Conjugates: A Pathway to Next-Generation Biomaterials |
| title_sort | hydrogels from protein polymer conjugates a pathway to next generation biomaterials |
| topic | hybrid hydrogels protein–polymer conjugates PEGylation |
| url | https://www.mdpi.com/2310-2861/11/2/96 |
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