Associations between metal constituents of ambient particulate matter and mortality in England: an ecological study
Objectives To investigate long-term associations between metal components of particulate matter (PM) and mortality and lung cancer incidence.Design Small area (ecological) study.Setting Population living in all wards (~9000 individuals per ward) in the London and Oxford area of England, comprising 1...
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BMJ Publishing Group
2019-12-01
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| Series: | BMJ Open |
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| author | Anna Hansell Kees de Hoogh Aurore Lavigne Anna Freni Sterrantino Silvia Liverani Marta Blangiardo John Molitor |
| author_facet | Anna Hansell Kees de Hoogh Aurore Lavigne Anna Freni Sterrantino Silvia Liverani Marta Blangiardo John Molitor |
| author_sort | Anna Hansell |
| collection | DOAJ |
| description | Objectives To investigate long-term associations between metal components of particulate matter (PM) and mortality and lung cancer incidence.Design Small area (ecological) study.Setting Population living in all wards (~9000 individuals per ward) in the London and Oxford area of England, comprising 13.6 million individuals.Exposure and outcome measures We used land use regression models originally used in the Transport related Air Pollution and Health Impacts—Integrated Methodologies for Assessing Particulate Matter study to estimate exposure to copper, iron and zinc in ambient air PM. We examined associations of metal exposure with Office for National Statistics mortality data from cardiovascular disease (CVD) and respiratory causes and with lung cancer incidence during 2008–2011.Results There were 108 478 CVD deaths, 48 483 respiratory deaths and 24 849 incident cases of lung cancer in the study period and area. Using Poisson regression models adjusted for area-level deprivation, tobacco sales and ethnicity, we found associations between cardiovascular mortality and PM2.5 copper with interdecile range (IDR 2.6–5.7 ng/m3) and IDR relative risk (RR) 1.005 (95%CI 1.001 to 1.009) and between respiratory mortality and PM10 zinc (IDR 1135–153 ng/m3) and IDR RR 1.136 (95%CI 1.010 to 1.277). We did not find relevant associations for lung cancer incidence. Metal elements were highly correlated.Conclusion Our analysis showed small but not fully consistent adverse associations between mortality and particulate metal exposures likely derived from non-tailpipe road traffic emissions (brake and tyre wear), which have previously been associated with increases in inflammatory markers in the blood. |
| format | Article |
| id | doaj-art-cee4eed209ff42c2bb4e85081f139f9c |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-cee4eed209ff42c2bb4e85081f139f9c2025-08-20T02:18:20ZengBMJ Publishing GroupBMJ Open2044-60552019-12-0191210.1136/bmjopen-2019-030140Associations between metal constituents of ambient particulate matter and mortality in England: an ecological studyAnna Hansell0Kees de Hoogh1Aurore Lavigne2Anna Freni Sterrantino3Silvia Liverani4Marta Blangiardo5John Molitor64 School of Public Health, Epidemiology and Biostatistics, Small Area Health Statistics Unit, MRC-PHE Centre for Environment and Health, Imperial College London, London, UK4 Swiss Tropical and Public Health Institute, Basel, Switzerland1 UFR MIME, Domaine universitaire du Pont de Bois, Université de Lille 3 UFR MIME, Villeneuve-d`Ascq, Nord-Pas-de-Calais-Picard, France2 Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK3 School of Mathematical Sciences, Queen Mary University of London, London, London, UKMRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK6 School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University CAPS, Corvallis, Oregon, USAObjectives To investigate long-term associations between metal components of particulate matter (PM) and mortality and lung cancer incidence.Design Small area (ecological) study.Setting Population living in all wards (~9000 individuals per ward) in the London and Oxford area of England, comprising 13.6 million individuals.Exposure and outcome measures We used land use regression models originally used in the Transport related Air Pollution and Health Impacts—Integrated Methodologies for Assessing Particulate Matter study to estimate exposure to copper, iron and zinc in ambient air PM. We examined associations of metal exposure with Office for National Statistics mortality data from cardiovascular disease (CVD) and respiratory causes and with lung cancer incidence during 2008–2011.Results There were 108 478 CVD deaths, 48 483 respiratory deaths and 24 849 incident cases of lung cancer in the study period and area. Using Poisson regression models adjusted for area-level deprivation, tobacco sales and ethnicity, we found associations between cardiovascular mortality and PM2.5 copper with interdecile range (IDR 2.6–5.7 ng/m3) and IDR relative risk (RR) 1.005 (95%CI 1.001 to 1.009) and between respiratory mortality and PM10 zinc (IDR 1135–153 ng/m3) and IDR RR 1.136 (95%CI 1.010 to 1.277). We did not find relevant associations for lung cancer incidence. Metal elements were highly correlated.Conclusion Our analysis showed small but not fully consistent adverse associations between mortality and particulate metal exposures likely derived from non-tailpipe road traffic emissions (brake and tyre wear), which have previously been associated with increases in inflammatory markers in the blood.https://bmjopen.bmj.com/content/9/12/e030140.full |
| spellingShingle | Anna Hansell Kees de Hoogh Aurore Lavigne Anna Freni Sterrantino Silvia Liverani Marta Blangiardo John Molitor Associations between metal constituents of ambient particulate matter and mortality in England: an ecological study BMJ Open |
| title | Associations between metal constituents of ambient particulate matter and mortality in England: an ecological study |
| title_full | Associations between metal constituents of ambient particulate matter and mortality in England: an ecological study |
| title_fullStr | Associations between metal constituents of ambient particulate matter and mortality in England: an ecological study |
| title_full_unstemmed | Associations between metal constituents of ambient particulate matter and mortality in England: an ecological study |
| title_short | Associations between metal constituents of ambient particulate matter and mortality in England: an ecological study |
| title_sort | associations between metal constituents of ambient particulate matter and mortality in england an ecological study |
| url | https://bmjopen.bmj.com/content/9/12/e030140.full |
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