Proteomic profiling of the local and systemic immune response to pediatric respiratory viral infections

Proteomic profiling of the local and systemic immune response to pediatric respiratory viral infections

ABSTRACT Viral lower respiratory tract infection (vLRTI) is a leading cause of hospitalization and death in children worldwide. Despite this, no studies have employed proteomics to characterize host immune responses to severe pediatric vLRTI in both the lower airway and systemic circulation. To addr...

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Main Authors: Emily Lydon, Christina M. Osborne, Brandie D. Wagner, Lilliam Ambroggio, J. Kirk Harris, Ron Reeder, Todd C. Carpenter, Aline B. Maddux, Matthew K. Leroue, Nadir Yehya, Joseph L. DeRisi, Mark W. Hall, Athena F. Zuppa, Joseph Carcillo, Kathleen Meert, Anil Sapru, Murray M. Pollack, Patrick McQuillen, Daniel A. Notterman, Charles R. Langelier, Peter M. Mourani
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:mSystems
Subjects:
proteomics
LRTI
pneumonia
host response
co-infection
viral pneumonia
Online Access:https://journals.asm.org/doi/10.1128/msystems.01335-24
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