A new role for fluorine-18-fluorodeoxyglucose positron-emission tomography/computed tomography in Erdheim-Chester disease
Erdheim-Chester disease (ECD) is a rare form of non-Langerhans cell histiocytosis, with multisystem manifestation such as bone pain, being the most common presenting symptom, cardiovascular or central nervous system involvement, interstitial lung disease, skin and orbital lesions, adrenal enlargemen...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2019-04-01
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| Series: | World Journal of Nuclear Medicine |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.wjnm_57_18 |
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| author | Ciska-Anne Van Keerberghen Antoine Harrouk Luca Leone |
| author_facet | Ciska-Anne Van Keerberghen Antoine Harrouk Luca Leone |
| author_sort | Ciska-Anne Van Keerberghen |
| collection | DOAJ |
| description | Erdheim-Chester disease (ECD) is a rare form of non-Langerhans cell histiocytosis, with multisystem manifestation such as bone pain, being the most common presenting symptom, cardiovascular or central nervous system involvement, interstitial lung disease, skin and orbital lesions, adrenal enlargement, retroperitoneal fibrosis and renal impairment as well fever, and weight loss. The disease is challenging to diagnose due to its rarity and mimicry of other infiltrative processes. Technetium-99 m bone scintigraphy showing pathological bone activity in the long bones is highly suggestive of ECD. However, not all patients have bone complaints. Till now, fluorine-18-fluorodeoxyglucose positron-emission tomography/computed tomography (18F-FDG PET/CT) was especially used after histological diagnosis to determine disease activity and extent, as well as the evaluation of treatment response. With this case, we suggest an additional role for 18F-FDG PET/CT earlier on in the diagnosis workup as follows: detecting a possible biopsy site to establish the diagnosis of ECD especially in a clinical context without bone pain. |
| format | Article |
| id | doaj-art-cee249c7ea0147b8911a51459def7980 |
| institution | Kabale University |
| issn | 1450-1147 1607-3312 |
| language | English |
| publishDate | 2019-04-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | World Journal of Nuclear Medicine |
| spelling | doaj-art-cee249c7ea0147b8911a51459def79802025-08-20T03:48:36ZengThieme Medical and Scientific Publishers Pvt. Ltd.World Journal of Nuclear Medicine1450-11471607-33122019-04-01180220120310.4103/wjnm.wjnm_57_18A new role for fluorine-18-fluorodeoxyglucose positron-emission tomography/computed tomography in Erdheim-Chester diseaseCiska-Anne Van Keerberghen0Antoine Harrouk1Luca Leone2Division of Nuclear Medicine and Molecular Imaging, University Hospitals LeuvenDepartment of Internal Medicine, St Elisabeth Hospital, BrusselsDepartment of Internal Medicine, St Elisabeth Hospital, BrusselsErdheim-Chester disease (ECD) is a rare form of non-Langerhans cell histiocytosis, with multisystem manifestation such as bone pain, being the most common presenting symptom, cardiovascular or central nervous system involvement, interstitial lung disease, skin and orbital lesions, adrenal enlargement, retroperitoneal fibrosis and renal impairment as well fever, and weight loss. The disease is challenging to diagnose due to its rarity and mimicry of other infiltrative processes. Technetium-99 m bone scintigraphy showing pathological bone activity in the long bones is highly suggestive of ECD. However, not all patients have bone complaints. Till now, fluorine-18-fluorodeoxyglucose positron-emission tomography/computed tomography (18F-FDG PET/CT) was especially used after histological diagnosis to determine disease activity and extent, as well as the evaluation of treatment response. With this case, we suggest an additional role for 18F-FDG PET/CT earlier on in the diagnosis workup as follows: detecting a possible biopsy site to establish the diagnosis of ECD especially in a clinical context without bone pain.http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.wjnm_57_18erdheim-chester diseasenon-langerhans cell histiocytosisnormal bone scintigraphysubcutaneous nodule |
| spellingShingle | Ciska-Anne Van Keerberghen Antoine Harrouk Luca Leone A new role for fluorine-18-fluorodeoxyglucose positron-emission tomography/computed tomography in Erdheim-Chester disease World Journal of Nuclear Medicine erdheim-chester disease non-langerhans cell histiocytosis normal bone scintigraphy subcutaneous nodule |
| title | A new role for fluorine-18-fluorodeoxyglucose positron-emission tomography/computed tomography in Erdheim-Chester disease |
| title_full | A new role for fluorine-18-fluorodeoxyglucose positron-emission tomography/computed tomography in Erdheim-Chester disease |
| title_fullStr | A new role for fluorine-18-fluorodeoxyglucose positron-emission tomography/computed tomography in Erdheim-Chester disease |
| title_full_unstemmed | A new role for fluorine-18-fluorodeoxyglucose positron-emission tomography/computed tomography in Erdheim-Chester disease |
| title_short | A new role for fluorine-18-fluorodeoxyglucose positron-emission tomography/computed tomography in Erdheim-Chester disease |
| title_sort | new role for fluorine 18 fluorodeoxyglucose positron emission tomography computed tomography in erdheim chester disease |
| topic | erdheim-chester disease non-langerhans cell histiocytosis normal bone scintigraphy subcutaneous nodule |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.wjnm_57_18 |
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