Total glucosides of paeony for rheumatoid arthritis: a protocol for a systematic review
Introduction Total glucosides of paeony (TGP) is a natural plant extract, which is widely used in China for treating rheumatoid arthritis (RA). Many relevant randomised controlled trials (RCTs) of TGP for RA are available, but they have not been systematically reviewed. This systematic review aims t...
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BMJ Publishing Group
2016-03-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/6/3/e010116.full |
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| author | Jing Luo Guo-Yan Yang Di-Er Jin Ying-Ze Zhang Jian-Ming Wang Wei-Ping Kong Qing-Wen Tao |
| author_facet | Jing Luo Guo-Yan Yang Di-Er Jin Ying-Ze Zhang Jian-Ming Wang Wei-Ping Kong Qing-Wen Tao |
| author_sort | Jing Luo |
| collection | DOAJ |
| description | Introduction Total glucosides of paeony (TGP) is a natural plant extract, which is widely used in China for treating rheumatoid arthritis (RA). Many relevant randomised controlled trials (RCTs) of TGP for RA are available, but they have not been systematically reviewed. This systematic review aims to examine the effectiveness and safety of TGP in patients with RA.Methods and analyses We will search for RCTs of TGP in the treatment of RA, performed up until February 2016, in PubMed, Embase, Cochrane Central Register of Controlled Trials, and four Chinese databases (Chinese Biomedical Database, China National Knowledge Infrastructure, Wanfang Database and Chinese Scientific Journal Database). Trial registers and reference lists of retrieved articles will also be searched to identify potential articles. RCTs comparing TGP with placebo, no treatment, or disease-modifying antirheumatic drugs for patients with RA will be retrieved. The primary outcomes will be disease improvement and disease remission. The secondary outcomes will be surrogate outcomes, symptoms, adverse effects, and quality of life. Two reviewers will independently extract data on participants, interventions, comparisons, outcomes, etc. The methodological quality of each included study will be evaluated using the Cochrane risk of bias tool, and the strength of evidence on prespecified outcomes will be assessed in accordance with the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach. Review Manager 5.3 software will be used for data analyses. Meta-analyses will be performed if the data are sufficiently homogeneous, both statistically and clinically. Possible publication bias will also be checked using funnel plots once the number of included studies is sufficient.Ethics and dissemination Ethics approval is not required, as this study will not involve patients. The results of this study will be submitted to a peer-reviewed journal for publication, to inform both clinical practice and further research.Trial registration number CRD42015026345. |
| format | Article |
| id | doaj-art-cedfe174ce2e44d8aea75716750f8dc6 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2016-03-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-cedfe174ce2e44d8aea75716750f8dc62025-02-11T13:45:14ZengBMJ Publishing GroupBMJ Open2044-60552016-03-016310.1136/bmjopen-2015-010116Total glucosides of paeony for rheumatoid arthritis: a protocol for a systematic reviewJing Luo0Guo-Yan Yang1Di-Er Jin2Ying-Ze Zhang3Jian-Ming Wang4Wei-Ping Kong5Qing-Wen Tao6University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA2National Institute of Complementary Medicine, Western Sydney University, Sydney, Australia1Traditional Chinese Medicine Department of Rheumatism, China–Japan Friendship Hospital, Beijing, China1Traditional Chinese Medicine Department of Rheumatism, China–Japan Friendship Hospital, Beijing, China1Traditional Chinese Medicine Department of Rheumatism, China–Japan Friendship Hospital, Beijing, China1Traditional Chinese Medicine Department of Rheumatism, China–Japan Friendship Hospital, Beijing, ChinaDepartment of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, ChinaIntroduction Total glucosides of paeony (TGP) is a natural plant extract, which is widely used in China for treating rheumatoid arthritis (RA). Many relevant randomised controlled trials (RCTs) of TGP for RA are available, but they have not been systematically reviewed. This systematic review aims to examine the effectiveness and safety of TGP in patients with RA.Methods and analyses We will search for RCTs of TGP in the treatment of RA, performed up until February 2016, in PubMed, Embase, Cochrane Central Register of Controlled Trials, and four Chinese databases (Chinese Biomedical Database, China National Knowledge Infrastructure, Wanfang Database and Chinese Scientific Journal Database). Trial registers and reference lists of retrieved articles will also be searched to identify potential articles. RCTs comparing TGP with placebo, no treatment, or disease-modifying antirheumatic drugs for patients with RA will be retrieved. The primary outcomes will be disease improvement and disease remission. The secondary outcomes will be surrogate outcomes, symptoms, adverse effects, and quality of life. Two reviewers will independently extract data on participants, interventions, comparisons, outcomes, etc. The methodological quality of each included study will be evaluated using the Cochrane risk of bias tool, and the strength of evidence on prespecified outcomes will be assessed in accordance with the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach. Review Manager 5.3 software will be used for data analyses. Meta-analyses will be performed if the data are sufficiently homogeneous, both statistically and clinically. Possible publication bias will also be checked using funnel plots once the number of included studies is sufficient.Ethics and dissemination Ethics approval is not required, as this study will not involve patients. The results of this study will be submitted to a peer-reviewed journal for publication, to inform both clinical practice and further research.Trial registration number CRD42015026345.https://bmjopen.bmj.com/content/6/3/e010116.full |
| spellingShingle | Jing Luo Guo-Yan Yang Di-Er Jin Ying-Ze Zhang Jian-Ming Wang Wei-Ping Kong Qing-Wen Tao Total glucosides of paeony for rheumatoid arthritis: a protocol for a systematic review BMJ Open |
| title | Total glucosides of paeony for rheumatoid arthritis: a protocol for a systematic review |
| title_full | Total glucosides of paeony for rheumatoid arthritis: a protocol for a systematic review |
| title_fullStr | Total glucosides of paeony for rheumatoid arthritis: a protocol for a systematic review |
| title_full_unstemmed | Total glucosides of paeony for rheumatoid arthritis: a protocol for a systematic review |
| title_short | Total glucosides of paeony for rheumatoid arthritis: a protocol for a systematic review |
| title_sort | total glucosides of paeony for rheumatoid arthritis a protocol for a systematic review |
| url | https://bmjopen.bmj.com/content/6/3/e010116.full |
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