The effects of combining electrical stimulation of the calf and thigh muscles on WOMAC pain in knee osteoarthritis: A double-blind, randomised, sham-controlled trial
Objective: To explore the effectiveness of a NMES device in improving pain and function for individuals with KOA. Method: This was a randomised, sham-controlled, superiority trial recruiting individuals with symptomatic KOA, with both participants and outcome assessors blinded to the treatment alloc...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Osteoarthritis and Cartilage Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665913125000433 |
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| author | Samuel Briggs-Price George Mills Linzy Houchen-Wolloff Enya Daynes Charlotte Gerlis Lorna E. Latimer Colin Esler Darren Targett Sally J. Singh |
| author_facet | Samuel Briggs-Price George Mills Linzy Houchen-Wolloff Enya Daynes Charlotte Gerlis Lorna E. Latimer Colin Esler Darren Targett Sally J. Singh |
| author_sort | Samuel Briggs-Price |
| collection | DOAJ |
| description | Objective: To explore the effectiveness of a NMES device in improving pain and function for individuals with KOA. Method: This was a randomised, sham-controlled, superiority trial recruiting individuals with symptomatic KOA, with both participants and outcome assessors blinded to the treatment allocation. Participants were randomised to receive either self-administered NMES, consisting of quadriceps (5 times a week) and footplate stimulation (7 times a week), or a sham device for 8 weeks. The primary outcome was the change in Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain domain at week 8. Results: 179 participants were randomised; 50.8 % female, mean (SD) age 66.9 (8.7) years. 164 attended the follow up visit. No difference in the WOMAC pain domain was seen between groups (−0.7; 95 % CI: −1.5, 0.1; P = 0.10), though within group improvements were reported in both groups (NMES: −1.5; 95 % CI: −2.0, 0.8; P < 0.01, sham: −0.8; 95 % CI: −1.4, 0.2; P < 0.01). There were no differences in strength, exercise and functional capacity, swelling, health related quality of life or anxiety and depression between groups. Sub-group analysis for NMES compliance or recruitment source did not change response in primary outcome. Conclusion: Use of an NMES device on the quadriceps and plantar flexors did not enhance pain relief or improve function over the sham control in people with KOA. |
| format | Article |
| id | doaj-art-cede3b3e021a42fc8ab9b489227f30e4 |
| institution | OA Journals |
| issn | 2665-9131 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Osteoarthritis and Cartilage Open |
| spelling | doaj-art-cede3b3e021a42fc8ab9b489227f30e42025-08-20T02:32:54ZengElsevierOsteoarthritis and Cartilage Open2665-91312025-06-017210060710.1016/j.ocarto.2025.100607The effects of combining electrical stimulation of the calf and thigh muscles on WOMAC pain in knee osteoarthritis: A double-blind, randomised, sham-controlled trialSamuel Briggs-Price0George Mills1Linzy Houchen-Wolloff2Enya Daynes3Charlotte Gerlis4Lorna E. Latimer5Colin Esler6Darren Targett7Sally J. Singh8Centre for Exercise and Rehabilitation Sciences, NIHR Leicester Biomedical Research Centre – Respiratory, Glenfield Hospital, Leicester, United Kingdom; Department of Respiratory Sciences, University of Leicester, Leicester, United KingdomCentre for Exercise and Rehabilitation Sciences, NIHR Leicester Biomedical Research Centre – Respiratory, Glenfield Hospital, Leicester, United Kingdom; Department of Respiratory Sciences, University of Leicester, Leicester, United Kingdom; Corresponding author. Centre for Exercise and Rehabilitation Sciences, NIHR Leicester Biomedical Research Centre – Respiratory, Glenfield Hospital, Leicester, United Kingdom.Centre for Exercise and Rehabilitation Sciences, NIHR Leicester Biomedical Research Centre – Respiratory, Glenfield Hospital, Leicester, United Kingdom; Department of Respiratory Sciences, University of Leicester, Leicester, United KingdomCentre for Exercise and Rehabilitation Sciences, NIHR Leicester Biomedical Research Centre – Respiratory, Glenfield Hospital, Leicester, United Kingdom; Department of Respiratory Sciences, University of Leicester, Leicester, United KingdomCentre for Exercise and Rehabilitation Sciences, NIHR Leicester Biomedical Research Centre – Respiratory, Glenfield Hospital, Leicester, United KingdomCentre for Exercise and Rehabilitation Sciences, NIHR Leicester Biomedical Research Centre – Respiratory, Glenfield Hospital, Leicester, United Kingdom; Department of Respiratory Sciences, University of Leicester, Leicester, United KingdomOrthopaedics, Leicester General Hospital, University Hospitals of Leicester, Gwendolen Road, Leicester, LE5 4PW, United KingdomPrimoris Contract Solutions Ltd, Ascot, Berkshire, United KingdomCentre for Exercise and Rehabilitation Sciences, NIHR Leicester Biomedical Research Centre – Respiratory, Glenfield Hospital, Leicester, United Kingdom; Department of Respiratory Sciences, University of Leicester, Leicester, United KingdomObjective: To explore the effectiveness of a NMES device in improving pain and function for individuals with KOA. Method: This was a randomised, sham-controlled, superiority trial recruiting individuals with symptomatic KOA, with both participants and outcome assessors blinded to the treatment allocation. Participants were randomised to receive either self-administered NMES, consisting of quadriceps (5 times a week) and footplate stimulation (7 times a week), or a sham device for 8 weeks. The primary outcome was the change in Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain domain at week 8. Results: 179 participants were randomised; 50.8 % female, mean (SD) age 66.9 (8.7) years. 164 attended the follow up visit. No difference in the WOMAC pain domain was seen between groups (−0.7; 95 % CI: −1.5, 0.1; P = 0.10), though within group improvements were reported in both groups (NMES: −1.5; 95 % CI: −2.0, 0.8; P < 0.01, sham: −0.8; 95 % CI: −1.4, 0.2; P < 0.01). There were no differences in strength, exercise and functional capacity, swelling, health related quality of life or anxiety and depression between groups. Sub-group analysis for NMES compliance or recruitment source did not change response in primary outcome. Conclusion: Use of an NMES device on the quadriceps and plantar flexors did not enhance pain relief or improve function over the sham control in people with KOA.http://www.sciencedirect.com/science/article/pii/S2665913125000433Knee osteoarthritisElectrical stimulationNMESRandomised controlled trialSham |
| spellingShingle | Samuel Briggs-Price George Mills Linzy Houchen-Wolloff Enya Daynes Charlotte Gerlis Lorna E. Latimer Colin Esler Darren Targett Sally J. Singh The effects of combining electrical stimulation of the calf and thigh muscles on WOMAC pain in knee osteoarthritis: A double-blind, randomised, sham-controlled trial Osteoarthritis and Cartilage Open Knee osteoarthritis Electrical stimulation NMES Randomised controlled trial Sham |
| title | The effects of combining electrical stimulation of the calf and thigh muscles on WOMAC pain in knee osteoarthritis: A double-blind, randomised, sham-controlled trial |
| title_full | The effects of combining electrical stimulation of the calf and thigh muscles on WOMAC pain in knee osteoarthritis: A double-blind, randomised, sham-controlled trial |
| title_fullStr | The effects of combining electrical stimulation of the calf and thigh muscles on WOMAC pain in knee osteoarthritis: A double-blind, randomised, sham-controlled trial |
| title_full_unstemmed | The effects of combining electrical stimulation of the calf and thigh muscles on WOMAC pain in knee osteoarthritis: A double-blind, randomised, sham-controlled trial |
| title_short | The effects of combining electrical stimulation of the calf and thigh muscles on WOMAC pain in knee osteoarthritis: A double-blind, randomised, sham-controlled trial |
| title_sort | effects of combining electrical stimulation of the calf and thigh muscles on womac pain in knee osteoarthritis a double blind randomised sham controlled trial |
| topic | Knee osteoarthritis Electrical stimulation NMES Randomised controlled trial Sham |
| url | http://www.sciencedirect.com/science/article/pii/S2665913125000433 |
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