Detection of urinary levels of matrix metalloproteinase-7 and tumor necrosis factor-like weak inducer of apoptosis in patients with IgA nephropathy and values in predicting disease progression

Detection of urinary levels of matrix metalloproteinase-7 and tumor necrosis factor-like weak inducer of apoptosis in patients with IgA nephropathy and values in predicting disease progression

ObjectiveTo explore the expressions of urinary matrix metalloproteinase-7 （MMP-7） and tumor necrosis factor-like weak inducer of apoptosis （TWEAK） in patients with IgA nephropathy （IgAN） and examine its predictive value.MethodsFrom January 2018 to March 2021，115 IgAN patients and 50 normal subjects...

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Bibliographic Details
Main Authors: Ma Yong-duo, Wang Cong, Li Hai-xiang, Wu Huan
Format: Article
Language:zho
Published: Editorial Department of Journal of Clinical Nephrology 2022-05-01
Series:Linchuang shenzangbing zazhi
Subjects:
Glomerulonephritis，IgA
Matrix metalloproteinase-7
Tumor necrosis factor-like weak inducer of apoptosis
Online Access:http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.05.006
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Summary:ObjectiveTo explore the expressions of urinary matrix metalloproteinase-7 （MMP-7） and tumor necrosis factor-like weak inducer of apoptosis （TWEAK） in patients with IgA nephropathy （IgAN） and examine its predictive value.MethodsFrom January 2018 to March 2021，115 IgAN patients and 50 normal subjects （control group） were selected.Based upon the progress of IgAN，115 cases of IgAN patients were divided into two groups of IgAN progressive （<italic>n</italic>=42） and IgAN non-progressive （<italic>n</italic>=73）.According to the IgAN Oxford classification criteria，they were assigned into two groups of MEST-C≥3 （<italic>n</italic>=45） and MEST-C&lt;3 （<italic>n</italic>=70）.The levels of urinary MMP-7 and TWEAK were compared between two groups.Multivariate Logistic regression was utilized for analyzing the risk factors of IgAN progression.Receiver operating characteristic （ROC） curve was plotted for examining the values of urinary MMP-7 and TWEAK levels in predicting IgAN progression.ResultsThe levels of urinary MMP-7 （15.72±7.85 <italic>vs</italic> 6.92±0.53 ng/mL） and TWEAK were significantly higher in IgAN progressive group than those in IgAN non-progressive group ［（958.47±42.60） <italic>vs</italic> （206.73±15.18）ng/mL，<italic>P</italic>&lt;0.001］.The levels of urinary MMP-7 ［（23.92±9.27） <italic>vs</italic> （18.15±8.36） ng/mL］ and TWEAK ［（1408.70±71.15） <italic>vs</italic> （1036.28±50.72） ng/mL］ were significantly higher in MEST-C≥3 score group than those in MEST-C&lt;3 score group （<italic>P</italic>&lt;0.001）.Multivariate Logistic regression analysis indicated that elevated levels of MMP-7 ［<italic>OR</italic>=2.986 95%<italic>CI</italic>（2.146，-8.513）］ and TWEAK ［<italic>OR</italic>=3.370 95%<italic>CI</italic>（2.752，-10.118）］ were the risk factors affecting the progression of IgAN.Receiver operating characteristic （ROC） curve indicated that the area under the curve （AUC） of MMP-7 and TWEAK in predicting IgAN progression was 0.948 （95% <italic>CI </italic>0.885-0.997） with a sensitivity of 97.5% and a specificity of 85.0%.Correlation analysis indicated that the urinary levels of MMP-7 and TWEAK were significantly positively correlated with M，E，S and T （<italic>P</italic>&lt;0.001）.ConclusionThe elevated urinary levels of MMP-7 and TWEAK are the risk factors affecting the progression of IgAN.Both may be used as biological indicators for predicting the progression of IgAN.
ISSN:1671-2390

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