Use of BRAF V600E as a Molecular Marker in Aggressive Colorectal Cancer
Aim: to compare the immunoexpression of BRAF V600E among stage of colorectal cancer. Methods: this was a cross sectional, and retrospective study involving Dukes’ stage A, B, and C colorectal carcinoma, each with 15 cases. Immunohistochemistry was performed in paraffin-embedded specimens of tumor m...
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| Format: | Article |
| Language: | English |
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Interna Publishing
2016-05-01
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| Series: | Acta Medica Indonesiana |
| Online Access: | https://www.actamedindones.org/index.php/ijim/article/view/75 |
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| author | Bethy S Hernowo Fenny Ariyanni Sri Suryanti Abdul H Hassan |
| author_facet | Bethy S Hernowo Fenny Ariyanni Sri Suryanti Abdul H Hassan |
| author_sort | Bethy S Hernowo |
| collection | DOAJ |
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Aim: to compare the immunoexpression of BRAF V600E among stage of colorectal cancer. Methods: this was a cross sectional, and retrospective study involving Dukes’ stage A, B, and C colorectal carcinoma, each with 15 cases. Immunohistochemistry was performed in paraffin-embedded specimens of tumor mass for the assessment of BRAF V600E. The proportion differences of immunoexpression of BRAF V600E among Dukes’stage A, B, and C were tested using Chi-Square test. Results: the result of positive BRAF V600E immunoexpression (moderately to strongly positive) in Dukes’stage A, B, and C were found in 1 of 15 cases, 4 of 15 cases and 13 of 15 cases respectively. BRAF V600E immunoexpression was statistically significant more frequent in Dukes’stage C (p<0,001, Chi-Square test). Conclusion: positive BRAF V600E immunoexpression could be used as a marker of aggresive colorectal carcinoma.
Key words: BRAF V600E, Dukes, immunoexpression, colorectal carcinoma
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| format | Article |
| id | doaj-art-ced999529d09402cb5a4c91e7ea9db3f |
| institution | OA Journals |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2016-05-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-ced999529d09402cb5a4c91e7ea9db3f2025-08-20T02:38:51ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322016-05-01462Use of BRAF V600E as a Molecular Marker in Aggressive Colorectal CancerBethy S Hernowo0Fenny Ariyanni1Sri Suryanti2Abdul H Hassan3Department of Anatomical Pathology, Faculty of Medicine, Universitas Padjadjaran, Bandung, IndonesiaDepartment of Anatomical Pathology, Faculty of Medicine, Universitas Padjadjaran, Bandung, IndonesiaDepartment of Anatomical Pathology, Faculty of Medicine, Universitas Padjadjaran, Bandung, IndonesiaDepartment of Anatomical Pathology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia Aim: to compare the immunoexpression of BRAF V600E among stage of colorectal cancer. Methods: this was a cross sectional, and retrospective study involving Dukes’ stage A, B, and C colorectal carcinoma, each with 15 cases. Immunohistochemistry was performed in paraffin-embedded specimens of tumor mass for the assessment of BRAF V600E. The proportion differences of immunoexpression of BRAF V600E among Dukes’stage A, B, and C were tested using Chi-Square test. Results: the result of positive BRAF V600E immunoexpression (moderately to strongly positive) in Dukes’stage A, B, and C were found in 1 of 15 cases, 4 of 15 cases and 13 of 15 cases respectively. BRAF V600E immunoexpression was statistically significant more frequent in Dukes’stage C (p<0,001, Chi-Square test). Conclusion: positive BRAF V600E immunoexpression could be used as a marker of aggresive colorectal carcinoma. Key words: BRAF V600E, Dukes, immunoexpression, colorectal carcinoma https://www.actamedindones.org/index.php/ijim/article/view/75 |
| spellingShingle | Bethy S Hernowo Fenny Ariyanni Sri Suryanti Abdul H Hassan Use of BRAF V600E as a Molecular Marker in Aggressive Colorectal Cancer Acta Medica Indonesiana |
| title | Use of BRAF V600E as a Molecular Marker in Aggressive Colorectal Cancer |
| title_full | Use of BRAF V600E as a Molecular Marker in Aggressive Colorectal Cancer |
| title_fullStr | Use of BRAF V600E as a Molecular Marker in Aggressive Colorectal Cancer |
| title_full_unstemmed | Use of BRAF V600E as a Molecular Marker in Aggressive Colorectal Cancer |
| title_short | Use of BRAF V600E as a Molecular Marker in Aggressive Colorectal Cancer |
| title_sort | use of braf v600e as a molecular marker in aggressive colorectal cancer |
| url | https://www.actamedindones.org/index.php/ijim/article/view/75 |
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