Efficacy of dietary polyphenol supplement in patients with non-alcoholic fatty liver disease: a network meta-analysis
BackgroundNon-alcoholic fatty liver disease (NAFLD) has become a public health issue worldwide. Dietary polyphenols are naturally occurring plant active ingredients and are widely employed in the treatment of NAFLD. However, the therapeutic effect is still controversial. In this study, a network met...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1582861/full |
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| author | Xiao-cui Wang Xiao-cui Wang Li Song Xin-han Wang Xin-han Wang |
| author_facet | Xiao-cui Wang Xiao-cui Wang Li Song Xin-han Wang Xin-han Wang |
| author_sort | Xiao-cui Wang |
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| description | BackgroundNon-alcoholic fatty liver disease (NAFLD) has become a public health issue worldwide. Dietary polyphenols are naturally occurring plant active ingredients and are widely employed in the treatment of NAFLD. However, the therapeutic effect is still controversial. In this study, a network meta-analysis (NMA) was performed to appraise the effects of various polyphenols on metabolic indices of NAFLD.MethodsPubMed, Embase, the Cochrane Library, and Web of Science were retrieved for English studies on dietary polyphenols in the treatment of NAFLD. Outcome measures were extracted from the included studies and compared using a Bayesian NMA model, encompassing body mass index (BMI), alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and necrosis factor alpha (TNF-α).ResultsIn total, 54 randomized controlled trials (RCTs) were included in this study, including 3,132 participants. It involved 13 single (or combined) dietary polyphenols. Naringenin could reduce serum TC (surface under the cumulative ranking curve: 94.59%) and TG (99.00%) in NAFLD patients. Catechin could decrease BMI (77.74%) and serum ALT (94.21%), AST (93.56%), TC (92.26%), and increase HDL-C (93.72%). Dihydromyricetin (DHM) was effective in reducing serum LDL-C (73.22%), and quercetin decreased serum TNF-α (99.47%).ConclusionCatechin may be the most appropriate dietary polyphenol supplement for NAFLD. Future studies should incorporate more RCTs to further validate the efficacy of dietary polyphenols (like DHM and quercetin), which are limited in sample sizes, in treating NAFLD. On the other hand, it is essential to investigate improvements in the bioavailability of these dietary polyphenols and to clarify their safety profiles. |
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| issn | 2296-861X |
| language | English |
| publishDate | 2025-05-01 |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-ced734fc0ef04c7ba97151c0681e0e412025-08-20T02:16:22ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-05-011210.3389/fnut.2025.15828611582861Efficacy of dietary polyphenol supplement in patients with non-alcoholic fatty liver disease: a network meta-analysisXiao-cui Wang0Xiao-cui Wang1Li Song2Xin-han Wang3Xin-han Wang4Ningxia Regional Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Regional High Incidence Disease, Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Ningxia Ethnomedicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, ChinaDepartment of Nephrology, Affiliated Hospital of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan, ChinaNingxia Regional Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Regional High Incidence Disease, Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Ningxia Ethnomedicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, ChinaBackgroundNon-alcoholic fatty liver disease (NAFLD) has become a public health issue worldwide. Dietary polyphenols are naturally occurring plant active ingredients and are widely employed in the treatment of NAFLD. However, the therapeutic effect is still controversial. In this study, a network meta-analysis (NMA) was performed to appraise the effects of various polyphenols on metabolic indices of NAFLD.MethodsPubMed, Embase, the Cochrane Library, and Web of Science were retrieved for English studies on dietary polyphenols in the treatment of NAFLD. Outcome measures were extracted from the included studies and compared using a Bayesian NMA model, encompassing body mass index (BMI), alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and necrosis factor alpha (TNF-α).ResultsIn total, 54 randomized controlled trials (RCTs) were included in this study, including 3,132 participants. It involved 13 single (or combined) dietary polyphenols. Naringenin could reduce serum TC (surface under the cumulative ranking curve: 94.59%) and TG (99.00%) in NAFLD patients. Catechin could decrease BMI (77.74%) and serum ALT (94.21%), AST (93.56%), TC (92.26%), and increase HDL-C (93.72%). Dihydromyricetin (DHM) was effective in reducing serum LDL-C (73.22%), and quercetin decreased serum TNF-α (99.47%).ConclusionCatechin may be the most appropriate dietary polyphenol supplement for NAFLD. Future studies should incorporate more RCTs to further validate the efficacy of dietary polyphenols (like DHM and quercetin), which are limited in sample sizes, in treating NAFLD. On the other hand, it is essential to investigate improvements in the bioavailability of these dietary polyphenols and to clarify their safety profiles.https://www.frontiersin.org/articles/10.3389/fnut.2025.1582861/fullnon-alcoholic fatty liver diseasedietary polyphenolnetwork meta-analysisrandomized controlled trialsmetabolic indicescatechin |
| spellingShingle | Xiao-cui Wang Xiao-cui Wang Li Song Xin-han Wang Xin-han Wang Efficacy of dietary polyphenol supplement in patients with non-alcoholic fatty liver disease: a network meta-analysis Frontiers in Nutrition non-alcoholic fatty liver disease dietary polyphenol network meta-analysis randomized controlled trials metabolic indices catechin |
| title | Efficacy of dietary polyphenol supplement in patients with non-alcoholic fatty liver disease: a network meta-analysis |
| title_full | Efficacy of dietary polyphenol supplement in patients with non-alcoholic fatty liver disease: a network meta-analysis |
| title_fullStr | Efficacy of dietary polyphenol supplement in patients with non-alcoholic fatty liver disease: a network meta-analysis |
| title_full_unstemmed | Efficacy of dietary polyphenol supplement in patients with non-alcoholic fatty liver disease: a network meta-analysis |
| title_short | Efficacy of dietary polyphenol supplement in patients with non-alcoholic fatty liver disease: a network meta-analysis |
| title_sort | efficacy of dietary polyphenol supplement in patients with non alcoholic fatty liver disease a network meta analysis |
| topic | non-alcoholic fatty liver disease dietary polyphenol network meta-analysis randomized controlled trials metabolic indices catechin |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1582861/full |
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