The Effects of <i>Anthyllis vulneraria</i> Hydroalcoholic Leaf Extract as an Adjuvant in Wound Healing
<i>Anthyllis vulneraria</i> is a traditional medicinal plant with confirmed anti-inflammatory properties, attributed to its high polyphenolic content. This study aimed to evaluate the wound-healing potential of <i>A. vulneraria</i> leaf extract in a rat burn model. Four group...
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2025-07-01
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| author | Olga-Maria Iova Gheorghe-Eduard Marin Ana-Maria Vlase Marcela Achim Dana Muntean Ioan Tomuţă Remus Moldovan Nicoleta Decea Bogdan Alexandru Gheban Sebastian Romeo Pintilie Oana-Alina Hoteiuc Roxana Denisa Capras Adriana Gabriela Filip |
| author_facet | Olga-Maria Iova Gheorghe-Eduard Marin Ana-Maria Vlase Marcela Achim Dana Muntean Ioan Tomuţă Remus Moldovan Nicoleta Decea Bogdan Alexandru Gheban Sebastian Romeo Pintilie Oana-Alina Hoteiuc Roxana Denisa Capras Adriana Gabriela Filip |
| author_sort | Olga-Maria Iova |
| collection | DOAJ |
| description | <i>Anthyllis vulneraria</i> is a traditional medicinal plant with confirmed anti-inflammatory properties, attributed to its high polyphenolic content. This study aimed to evaluate the wound-healing potential of <i>A. vulneraria</i> leaf extract in a rat burn model. Four groups of eight Wistar rats each received the following daily topical applications for 14 days: vehicle cream (negative control); silver sulfadiazine (positive control); or plant-based creams containing either 1 mg/cm<sup>2</sup> or 2 mg/cm<sup>2</sup> of polyphenols (experimental groups 1 and 2, respectively). On days 7 and 14, four animals per group were euthanized for histological and oxidative stress evaluations. LC-MS/MS analysis of the leaf extract identified hyperoside, ferulic acid, and <i>p</i>-coumaric acid as major constituents. Experimental group 1 showed significantly enhanced wound closure on days 5 and 7, while group 2 exhibited a significant effect on day 5. All oxidative stress markers, except catalase activity, differed significantly among the groups, with the most favorable results observed in group 2. IL-8 levels decreased after the extract treatment, while no significant microscopic changes were observed. These results indicate that <i>A. vulneraria</i> leaf extract may serve as a valuable adjuvant in burn wound healing. |
| format | Article |
| id | doaj-art-ced40c64eb564b2398bc60eda0821251 |
| institution | Kabale University |
| issn | 2076-3417 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj-art-ced40c64eb564b2398bc60eda08212512025-08-20T03:36:35ZengMDPI AGApplied Sciences2076-34172025-07-011515838810.3390/app15158388The Effects of <i>Anthyllis vulneraria</i> Hydroalcoholic Leaf Extract as an Adjuvant in Wound HealingOlga-Maria Iova0Gheorghe-Eduard Marin1Ana-Maria Vlase2Marcela Achim3Dana Muntean4Ioan Tomuţă5Remus Moldovan6Nicoleta Decea7Bogdan Alexandru Gheban8Sebastian Romeo Pintilie9Oana-Alina Hoteiuc10Roxana Denisa Capras11Adriana Gabriela Filip12Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400349 Cluj-Napoca, RomaniaFaculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400349 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Botany, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 23 Gheorghe Marinescu Street, 400337 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaPhysiology Department, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400126 Cluj-Napoca, RomaniaPhysiology Department, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400126 Cluj-Napoca, RomaniaDepartment 1, Faculty of Medical Assistance and Health Sciences, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400126 Cluj-Napoca, RomaniaFaculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400349 Cluj-Napoca, RomaniaPhysiology Department, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400126 Cluj-Napoca, RomaniaDepartment of Anatomy and Embriology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Anatomy and Embriology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania<i>Anthyllis vulneraria</i> is a traditional medicinal plant with confirmed anti-inflammatory properties, attributed to its high polyphenolic content. This study aimed to evaluate the wound-healing potential of <i>A. vulneraria</i> leaf extract in a rat burn model. Four groups of eight Wistar rats each received the following daily topical applications for 14 days: vehicle cream (negative control); silver sulfadiazine (positive control); or plant-based creams containing either 1 mg/cm<sup>2</sup> or 2 mg/cm<sup>2</sup> of polyphenols (experimental groups 1 and 2, respectively). On days 7 and 14, four animals per group were euthanized for histological and oxidative stress evaluations. LC-MS/MS analysis of the leaf extract identified hyperoside, ferulic acid, and <i>p</i>-coumaric acid as major constituents. Experimental group 1 showed significantly enhanced wound closure on days 5 and 7, while group 2 exhibited a significant effect on day 5. All oxidative stress markers, except catalase activity, differed significantly among the groups, with the most favorable results observed in group 2. IL-8 levels decreased after the extract treatment, while no significant microscopic changes were observed. These results indicate that <i>A. vulneraria</i> leaf extract may serve as a valuable adjuvant in burn wound healing.https://www.mdpi.com/2076-3417/15/15/8388<i>Anthyllis vulneraria</i>polyphenolsanimal burn modelwound healing |
| spellingShingle | Olga-Maria Iova Gheorghe-Eduard Marin Ana-Maria Vlase Marcela Achim Dana Muntean Ioan Tomuţă Remus Moldovan Nicoleta Decea Bogdan Alexandru Gheban Sebastian Romeo Pintilie Oana-Alina Hoteiuc Roxana Denisa Capras Adriana Gabriela Filip The Effects of <i>Anthyllis vulneraria</i> Hydroalcoholic Leaf Extract as an Adjuvant in Wound Healing Applied Sciences <i>Anthyllis vulneraria</i> polyphenols animal burn model wound healing |
| title | The Effects of <i>Anthyllis vulneraria</i> Hydroalcoholic Leaf Extract as an Adjuvant in Wound Healing |
| title_full | The Effects of <i>Anthyllis vulneraria</i> Hydroalcoholic Leaf Extract as an Adjuvant in Wound Healing |
| title_fullStr | The Effects of <i>Anthyllis vulneraria</i> Hydroalcoholic Leaf Extract as an Adjuvant in Wound Healing |
| title_full_unstemmed | The Effects of <i>Anthyllis vulneraria</i> Hydroalcoholic Leaf Extract as an Adjuvant in Wound Healing |
| title_short | The Effects of <i>Anthyllis vulneraria</i> Hydroalcoholic Leaf Extract as an Adjuvant in Wound Healing |
| title_sort | effects of i anthyllis vulneraria i hydroalcoholic leaf extract as an adjuvant in wound healing |
| topic | <i>Anthyllis vulneraria</i> polyphenols animal burn model wound healing |
| url | https://www.mdpi.com/2076-3417/15/15/8388 |
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