Medicamentous abortion with mifepristone and misoprostol in Serbia and Montenegro
Background/Aim. Medicamentous abortion was first introduced in Serbia and Montenegro in September 2001. The aim of this study was to assess the efficiency, side effects, and acceptability of medicamentous abortion using mifeprostone orally (600 mg), and 48 hours later, misoprostol both orally and va...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2006-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2006/0042-84500606558S.pdf |
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| author | Stojnić Jelena Ljubić Aleksandar Jeremić Katarina Radunović Nebojša Tulić Ivan Bošković Vladimir Dukanac Jelena |
| author_facet | Stojnić Jelena Ljubić Aleksandar Jeremić Katarina Radunović Nebojša Tulić Ivan Bošković Vladimir Dukanac Jelena |
| author_sort | Stojnić Jelena |
| collection | DOAJ |
| description | Background/Aim. Medicamentous abortion was first introduced in Serbia and Montenegro in September 2001. The aim of this study was to assess the efficiency, side effects, and acceptability of medicamentous abortion using mifeprostone orally (600 mg), and 48 hours later, misoprostol both orally and vaginally in different regiments in our population (400 mcg, 600 mcg, 800 mcg). Methods. A total of 235 consecutive women with pregnancies up to 49 days of gestational age were assigned to 4 groups according to the different misoprostol regiment (group I 400 mcg, group II 600 mcg, group III 800 mcg orally, and group IV 800 mcg both orally and vaginally). The principal outcome measure was a successful abortion defined as a complete expulsion of intrauterine contents without a need for surgical intervention 14 days after the procedure. Other outcome measures were the following: drug related effects, and adverse effects related to the abortion process. Results. In general, the success rate was 50%, 89.48%, 75% and 92.11% in the groups I, II, III, and IV, respectively, as judged by the complete expulsion of the intrauterine contents without surgical intervention (t1:4 = 7.005; t2:4 = 0.3872, t3:4 = 2.9784, p < 0.01). The incidence of adverse effects (vomiting, abdominal pain, bleeding, and fever) was low in general, but among our groups it occurred mostly with the higher doses of orally applied misoprostol (800 and 600 mcg). Only one case required urgent curettage for heavy vaginal bleeding, and two blood transfusions, as well. No cases of intact pregnancies were recorded in the study. Conclusion. Our study showed that a mifepristone dose of 600 mg orally, and misoprostol 400 mcg orally and 400 mcg vaginally were most effective. Thus, a combination of mifepristone and misoprostol for medicamentous abortion should take a higher proportion in the termination of early pregnancy in our population. |
| format | Article |
| id | doaj-art-ced3ccdfe29747258baa213f24f53bbf |
| institution | Kabale University |
| issn | 0042-8450 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-ced3ccdfe29747258baa213f24f53bbf2025-08-20T03:24:55ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502006-01-0163655856310.2298/VSP0606558SMedicamentous abortion with mifepristone and misoprostol in Serbia and MontenegroStojnić JelenaLjubić AleksandarJeremić KatarinaRadunović NebojšaTulić IvanBošković VladimirDukanac JelenaBackground/Aim. Medicamentous abortion was first introduced in Serbia and Montenegro in September 2001. The aim of this study was to assess the efficiency, side effects, and acceptability of medicamentous abortion using mifeprostone orally (600 mg), and 48 hours later, misoprostol both orally and vaginally in different regiments in our population (400 mcg, 600 mcg, 800 mcg). Methods. A total of 235 consecutive women with pregnancies up to 49 days of gestational age were assigned to 4 groups according to the different misoprostol regiment (group I 400 mcg, group II 600 mcg, group III 800 mcg orally, and group IV 800 mcg both orally and vaginally). The principal outcome measure was a successful abortion defined as a complete expulsion of intrauterine contents without a need for surgical intervention 14 days after the procedure. Other outcome measures were the following: drug related effects, and adverse effects related to the abortion process. Results. In general, the success rate was 50%, 89.48%, 75% and 92.11% in the groups I, II, III, and IV, respectively, as judged by the complete expulsion of the intrauterine contents without surgical intervention (t1:4 = 7.005; t2:4 = 0.3872, t3:4 = 2.9784, p < 0.01). The incidence of adverse effects (vomiting, abdominal pain, bleeding, and fever) was low in general, but among our groups it occurred mostly with the higher doses of orally applied misoprostol (800 and 600 mcg). Only one case required urgent curettage for heavy vaginal bleeding, and two blood transfusions, as well. No cases of intact pregnancies were recorded in the study. Conclusion. Our study showed that a mifepristone dose of 600 mg orally, and misoprostol 400 mcg orally and 400 mcg vaginally were most effective. Thus, a combination of mifepristone and misoprostol for medicamentous abortion should take a higher proportion in the termination of early pregnancy in our population.http://www.doiserbia.nb.rs/img/doi/0042-8450/2006/0042-84500606558S.pdfabortioninducedmifepristonemisoprostoldrug therapypregnancy treatment outcomedrug administration routesdrug evaluation |
| spellingShingle | Stojnić Jelena Ljubić Aleksandar Jeremić Katarina Radunović Nebojša Tulić Ivan Bošković Vladimir Dukanac Jelena Medicamentous abortion with mifepristone and misoprostol in Serbia and Montenegro Vojnosanitetski Pregled abortion induced mifepristone misoprostol drug therapy pregnancy treatment outcome drug administration routes drug evaluation |
| title | Medicamentous abortion with mifepristone and misoprostol in Serbia and Montenegro |
| title_full | Medicamentous abortion with mifepristone and misoprostol in Serbia and Montenegro |
| title_fullStr | Medicamentous abortion with mifepristone and misoprostol in Serbia and Montenegro |
| title_full_unstemmed | Medicamentous abortion with mifepristone and misoprostol in Serbia and Montenegro |
| title_short | Medicamentous abortion with mifepristone and misoprostol in Serbia and Montenegro |
| title_sort | medicamentous abortion with mifepristone and misoprostol in serbia and montenegro |
| topic | abortion induced mifepristone misoprostol drug therapy pregnancy treatment outcome drug administration routes drug evaluation |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2006/0042-84500606558S.pdf |
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