Integrative immunology identified interferome signatures in uveitis and systemic disease-associated uveitis

Integrative immunology identified interferome signatures in uveitis and systemic disease-associated uveitis

IntroductionUveitis accounts for up to 25% of global legal blindness and involves intraocular inflammation, classifed as infectious or non-infectious. Its complex pathophysiology includes dysregulated cytokines, particularly interferons (IFNs). However, the global signature of type I, II, and III in...

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Main Authors: Danielle Dias Munhoz, Dennyson Leandro M. Fonseca, Igor Salerno Filgueiras, Haroldo Dutra Dias, Helder I. Nakaya, Igor Jurisica, Hans D. Ochs, Lena F. Schimke, Luiz Vicente Rizzo, Otavio Cabral-Marques
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
non-infectious uveitis
blood transcriptome
interferon-regulated genes
cytokines
integrative analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1509805/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1509805/full

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