TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1α axis in melanoma

TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1α axis in melanoma

TIPE (TNFAIP8) has been identified as an oncogene and participates in tumor biology. However, how its role in the metabolism of tumor cells during melanoma development remains unclear. Here, we demonstrated that TIPE promoted glycolysis by interacting with pyruvate kinase M2 (PKM2) in melanoma. We f...

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Bibliographic Details
Main Authors: Maojin Tian, Le Yang, Ziqian Zhao, Jigang Li, Lianqing Wang, Qingqing Yin, Wei Hu, Yunwei Lou, Jianxin Du, Peiqing Zhao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
TIPE
glycolysis
PKM2
HIF-1α
melanoma
Online Access:https://elifesciences.org/articles/92741
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