A novel 22-bp InDel within FGF7 gene is significantly associated with growth traits in goat
Fibroblast growth factor 7 (FGF7) is involved in lipid metabolism, which is considered as a candidate gene with close relation with muscle development by eGWAs and RNA-Seq analyses. To date, limited research has been conducted on the relationship between FGF7 gene and growth traits. The main objecti...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Animal Biotechnology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/10495398.2023.2262537 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849712101568806912 |
|---|---|
| author | Xian-feng Wu Yuan Liu Ying-gang Wang Fu Zhang Wen-yang Li |
| author_facet | Xian-feng Wu Yuan Liu Ying-gang Wang Fu Zhang Wen-yang Li |
| author_sort | Xian-feng Wu |
| collection | DOAJ |
| description | Fibroblast growth factor 7 (FGF7) is involved in lipid metabolism, which is considered as a candidate gene with close relation with muscle development by eGWAs and RNA-Seq analyses. To date, limited research has been conducted on the relationship between FGF7 gene and growth traits. The main objective of this work was to further investigate the association between novel InDel within FGF7 gene and growth traits in goat. Herein, FGF7 mRNA expression levels were investigated in various Fuqing goat tissues. We found that FGF7 gene was expressed in six adult goat tissues with the highest mRNA levels in adipose tissue. This result suggested that FGF7 gene might play a critical role in fat deposition. We also detected potential polymorphisms in Fuqing, Nubian and Jianyang Daer breeds. A 22-bp InDel polymorphism in FGF7 gene was detected in 396 goats and the three genotypes were designated as II, ID, and DD. Correlation analysis revealed that InDel polymorphism was significantly associated with growth traits (P < 0.05). Goats with genotypes ID and/or II had superior growth traits compared to those with genotype DD. In summary, our findings suggested that the 22-bp InDel within FGF7 gene could act as a molecular marker to improve the growth traits of goats in breeding programs. |
| format | Article |
| id | doaj-art-cecb018be3f84fe8892bc0640ed22398 |
| institution | DOAJ |
| issn | 1049-5398 1532-2378 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Animal Biotechnology |
| spelling | doaj-art-cecb018be3f84fe8892bc0640ed223982025-08-20T03:14:23ZengTaylor & Francis GroupAnimal Biotechnology1049-53981532-23782024-12-0135110.1080/10495398.2023.2262537A novel 22-bp InDel within FGF7 gene is significantly associated with growth traits in goatXian-feng Wu0Yuan Liu1Ying-gang Wang2Fu Zhang3Wen-yang Li4Fujian Academy of Agricultural Sciences, Fuzhou, Fujian, ChinaFujian Academy of Agricultural Sciences, Fuzhou, Fujian, ChinaCollege of Animal Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian, ChinaCollege of Animal Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian, ChinaFujian Academy of Agricultural Sciences, Fuzhou, Fujian, ChinaFibroblast growth factor 7 (FGF7) is involved in lipid metabolism, which is considered as a candidate gene with close relation with muscle development by eGWAs and RNA-Seq analyses. To date, limited research has been conducted on the relationship between FGF7 gene and growth traits. The main objective of this work was to further investigate the association between novel InDel within FGF7 gene and growth traits in goat. Herein, FGF7 mRNA expression levels were investigated in various Fuqing goat tissues. We found that FGF7 gene was expressed in six adult goat tissues with the highest mRNA levels in adipose tissue. This result suggested that FGF7 gene might play a critical role in fat deposition. We also detected potential polymorphisms in Fuqing, Nubian and Jianyang Daer breeds. A 22-bp InDel polymorphism in FGF7 gene was detected in 396 goats and the three genotypes were designated as II, ID, and DD. Correlation analysis revealed that InDel polymorphism was significantly associated with growth traits (P < 0.05). Goats with genotypes ID and/or II had superior growth traits compared to those with genotype DD. In summary, our findings suggested that the 22-bp InDel within FGF7 gene could act as a molecular marker to improve the growth traits of goats in breeding programs.https://www.tandfonline.com/doi/10.1080/10495398.2023.2262537GoatFGF7 geneInDelgrowth traitsmarker-assisted selection (MAS) |
| spellingShingle | Xian-feng Wu Yuan Liu Ying-gang Wang Fu Zhang Wen-yang Li A novel 22-bp InDel within FGF7 gene is significantly associated with growth traits in goat Animal Biotechnology Goat FGF7 gene InDel growth traits marker-assisted selection (MAS) |
| title | A novel 22-bp InDel within FGF7 gene is significantly associated with growth traits in goat |
| title_full | A novel 22-bp InDel within FGF7 gene is significantly associated with growth traits in goat |
| title_fullStr | A novel 22-bp InDel within FGF7 gene is significantly associated with growth traits in goat |
| title_full_unstemmed | A novel 22-bp InDel within FGF7 gene is significantly associated with growth traits in goat |
| title_short | A novel 22-bp InDel within FGF7 gene is significantly associated with growth traits in goat |
| title_sort | novel 22 bp indel within fgf7 gene is significantly associated with growth traits in goat |
| topic | Goat FGF7 gene InDel growth traits marker-assisted selection (MAS) |
| url | https://www.tandfonline.com/doi/10.1080/10495398.2023.2262537 |
| work_keys_str_mv | AT xianfengwu anovel22bpindelwithinfgf7geneissignificantlyassociatedwithgrowthtraitsingoat AT yuanliu anovel22bpindelwithinfgf7geneissignificantlyassociatedwithgrowthtraitsingoat AT yinggangwang anovel22bpindelwithinfgf7geneissignificantlyassociatedwithgrowthtraitsingoat AT fuzhang anovel22bpindelwithinfgf7geneissignificantlyassociatedwithgrowthtraitsingoat AT wenyangli anovel22bpindelwithinfgf7geneissignificantlyassociatedwithgrowthtraitsingoat AT xianfengwu novel22bpindelwithinfgf7geneissignificantlyassociatedwithgrowthtraitsingoat AT yuanliu novel22bpindelwithinfgf7geneissignificantlyassociatedwithgrowthtraitsingoat AT yinggangwang novel22bpindelwithinfgf7geneissignificantlyassociatedwithgrowthtraitsingoat AT fuzhang novel22bpindelwithinfgf7geneissignificantlyassociatedwithgrowthtraitsingoat AT wenyangli novel22bpindelwithinfgf7geneissignificantlyassociatedwithgrowthtraitsingoat |