Nut consumption, linoleic and α-linolenic acid intakes, and genetics: how fatty acid desaturase 1 impacts plasma fatty acids and type 2 diabetes risk in EPIC-InterAct and PREDIMED studies

Nut consumption, linoleic and α-linolenic acid intakes, and genetics: how fatty acid desaturase 1 impacts plasma fatty acids and type 2 diabetes risk in EPIC-InterAct and PREDIMED studies

Abstract Background Dietary guidelines recommend replacing saturated fatty acid with unsaturated fats, particularly polyunsaturated fatty acids. Cohort studies do not suggest a clear benefit of higher intake of polyunsaturated fatty acids but, in contrast, higher circulating linoleic acid (LA) level...

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Main Authors: Susanne Jäger, Olga Kuxhaus, Marcela Prada, Inge Huybrechts, Tammy Y. N. Tong, Nita G. Forouhi, Cristina Razquin, Dolores Corella, Miguel A. Martinez-Gonzalez, Christina C. Dahm, Daniel B. Ibsen, Anne Tjønneland, Jytte Halkjær, Chloé Marques, Claire Cadeau, Xuan Ren, Verena Katzke, Benedetta Bendinelli, Claudia Agnoli, Alberto Catalano, Marta Farràs, Maria-Jose Sánchez, María Dolores Chirlaque López, Marcela Guevara, Dagfinn Aune, Stephen J. Sharp, Nicholas J. Wareham, Matthias B. Schulze
Format: Article
Language:English
Published: BMC 2025-06-01
Series:BMC Medicine
Subjects:
Polyunsaturated fatty acids
Fatty acid desaturase
Plasma phospholipid fatty acids
Cohort study
Randomized controlled trial
Online Access:https://doi.org/10.1186/s12916-025-04187-8
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