Metabolism of Microbiota in Critical Illness (Review and Postulates)
This article discusses the importance of eliciting the mechanisms of action and the metabolism of microbiota in the critically ill patients, as well as the role of nutrition specialist in the management of these patients.In critically ill patients the impaired regulation of endogenous metabolic proc...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2019-12-01
|
| Series: | Общая реаниматология |
| Subjects: | |
| Online Access: | https://www.reanimatology.com/rmt/article/view/1833 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849242786822356992 |
|---|---|
| author | Natalia V. Beloborodova |
| author_facet | Natalia V. Beloborodova |
| author_sort | Natalia V. Beloborodova |
| collection | DOAJ |
| description | This article discusses the importance of eliciting the mechanisms of action and the metabolism of microbiota in the critically ill patients, as well as the role of nutrition specialist in the management of these patients.In critically ill patients the impaired regulation of endogenous metabolic processes and protein-energy deficiency are aggravated by abnormal microbiota metabolic processes. There is growing awareness of the importance of studying microbial metabolism in the general metabolic process. Its implications for the improved efficacy of treatment in critical care and rehabilitation are obvious.Current international intensive care guidelines are being constantly revised in response to the new research data available on the mechanisms of critical illness. The course of the latter may significantly associate with the metabolic activity of human microbiota. Active management of metabolic processes is being sought through the subordination of bacterial metabolism to the interests of the host. Both antimicrobial and bioformulations (prebiotics, metabiotics) will be used in the long term in a targeted manner with the control of key microbial metabolites through available laboratory monitoring tools.Based on the literature data and the original research, the author formulates postulates of the microbiota metabolism in critical illness, introduces the concepts of «invisible organ dysfunction» and «signaling bacterial molecules», offers answers to the eternal «what is to be done?» question and suggests using a number of microbial aromatic amino acids metabolites as an integral indicator of a course of critical illness. |
| format | Article |
| id | doaj-art-cec8ce2df4574553b63ed20a95c8a3cb |
| institution | Kabale University |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-cec8ce2df4574553b63ed20a95c8a3cb2025-08-20T03:59:40ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102019-12-01156627910.15360/1813-9779-2019-6-62-791718Metabolism of Microbiota in Critical Illness (Review and Postulates)Natalia V. Beloborodova0V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and RehabilitologyThis article discusses the importance of eliciting the mechanisms of action and the metabolism of microbiota in the critically ill patients, as well as the role of nutrition specialist in the management of these patients.In critically ill patients the impaired regulation of endogenous metabolic processes and protein-energy deficiency are aggravated by abnormal microbiota metabolic processes. There is growing awareness of the importance of studying microbial metabolism in the general metabolic process. Its implications for the improved efficacy of treatment in critical care and rehabilitation are obvious.Current international intensive care guidelines are being constantly revised in response to the new research data available on the mechanisms of critical illness. The course of the latter may significantly associate with the metabolic activity of human microbiota. Active management of metabolic processes is being sought through the subordination of bacterial metabolism to the interests of the host. Both antimicrobial and bioformulations (prebiotics, metabiotics) will be used in the long term in a targeted manner with the control of key microbial metabolites through available laboratory monitoring tools.Based on the literature data and the original research, the author formulates postulates of the microbiota metabolism in critical illness, introduces the concepts of «invisible organ dysfunction» and «signaling bacterial molecules», offers answers to the eternal «what is to be done?» question and suggests using a number of microbial aromatic amino acids metabolites as an integral indicator of a course of critical illness.https://www.reanimatology.com/rmt/article/view/1833critical statesmetabolism of bacteriamicrobiotamitochondrial dysfunctionantimicrobial therapybio-drugs |
| spellingShingle | Natalia V. Beloborodova Metabolism of Microbiota in Critical Illness (Review and Postulates) Общая реаниматология critical states metabolism of bacteria microbiota mitochondrial dysfunction antimicrobial therapy bio-drugs |
| title | Metabolism of Microbiota in Critical Illness (Review and Postulates) |
| title_full | Metabolism of Microbiota in Critical Illness (Review and Postulates) |
| title_fullStr | Metabolism of Microbiota in Critical Illness (Review and Postulates) |
| title_full_unstemmed | Metabolism of Microbiota in Critical Illness (Review and Postulates) |
| title_short | Metabolism of Microbiota in Critical Illness (Review and Postulates) |
| title_sort | metabolism of microbiota in critical illness review and postulates |
| topic | critical states metabolism of bacteria microbiota mitochondrial dysfunction antimicrobial therapy bio-drugs |
| url | https://www.reanimatology.com/rmt/article/view/1833 |
| work_keys_str_mv | AT nataliavbeloborodova metabolismofmicrobiotaincriticalillnessreviewandpostulates |