In Silico Trials of Prosthetic Valves Replicate Methodologies for Evaluating the Fatigue Life of Artificial Leaflets to Expand Beyond In Vitro Tests and Conventional Clinical Trials

In Silico Trials of Prosthetic Valves Replicate Methodologies for Evaluating the Fatigue Life of Artificial Leaflets to Expand Beyond In Vitro Tests and Conventional Clinical Trials

<b>Background</b>: Fatigue failure of artificial leaflets significantly limits the durability of prosthetic valves. However, the costs and complexities associated with in vitro testing and conventional clinical trials to investigate the fatigue life of leaflets are progressively escalati...

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Bibliographic Details
Main Authors: Pengzhi Mao, Min Jin, Wei Li, Haitao Zhang, Haozheng Li, Shilong Li, Yuting Yang, Minjia Zhu, Yue Shi, Xuehuan Zhang, Duanduan Chen
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomedicines
Subjects:
in silico trials
artificial leaflets
fatigue life
crack propagation
Online Access:https://www.mdpi.com/2227-9059/13/5/1135
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