Recent advances in mitochondrial replacement therapy and its future expectations
Abstract The prevention of mitochondrial diseases is particularly important due to the lack of specific therapies. Therefore, mitochondrial replacement therapy (MRT) is expected to be a technology to prevent mitochondrial diseases. Admittedly, this technology sparked a lot of controversy and discuss...
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | Clinical and Translational Discovery |
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| Online Access: | https://doi.org/10.1002/ctd2.70010 |
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| _version_ | 1849723167938969600 |
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| author | Qifeng Lyu Weiwei Zou Taosheng Huang |
| author_facet | Qifeng Lyu Weiwei Zou Taosheng Huang |
| author_sort | Qifeng Lyu |
| collection | DOAJ |
| description | Abstract The prevention of mitochondrial diseases is particularly important due to the lack of specific therapies. Therefore, mitochondrial replacement therapy (MRT) is expected to be a technology to prevent mitochondrial diseases. Admittedly, this technology sparked a lot of controversy and discussion. In this article, we review the recent advances in MRT, discuss its safety and ethical issues, and finally explore its potential to completely block the inheritance of mitochondrial diseases. |
| format | Article |
| id | doaj-art-cec49f543ac346548a52be8dd17cc232 |
| institution | DOAJ |
| issn | 2768-0622 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Discovery |
| spelling | doaj-art-cec49f543ac346548a52be8dd17cc2322025-08-20T03:11:06ZengWileyClinical and Translational Discovery2768-06222025-02-0151n/an/a10.1002/ctd2.70010Recent advances in mitochondrial replacement therapy and its future expectationsQifeng Lyu0Weiwei Zou1Taosheng Huang2Department of Assisted ReproductionShanghai Ninth People's HospitalShanghai JiaoTong University School of MedicineShanghaiChinaDepartment of Obstetrics and GynecologyReproductive Medicine Center, The First Affiliated Hospital of Anhui Medical UniversityHefeiChinaInstitute of Medical Genetics & Genomics (iMGG)Fudan UniversityShanghaiChinaAbstract The prevention of mitochondrial diseases is particularly important due to the lack of specific therapies. Therefore, mitochondrial replacement therapy (MRT) is expected to be a technology to prevent mitochondrial diseases. Admittedly, this technology sparked a lot of controversy and discussion. In this article, we review the recent advances in MRT, discuss its safety and ethical issues, and finally explore its potential to completely block the inheritance of mitochondrial diseases.https://doi.org/10.1002/ctd2.70010mitochondrial diseasesmitochondrial replacement therapy (MRT)mtDNA |
| spellingShingle | Qifeng Lyu Weiwei Zou Taosheng Huang Recent advances in mitochondrial replacement therapy and its future expectations Clinical and Translational Discovery mitochondrial diseases mitochondrial replacement therapy (MRT) mtDNA |
| title | Recent advances in mitochondrial replacement therapy and its future expectations |
| title_full | Recent advances in mitochondrial replacement therapy and its future expectations |
| title_fullStr | Recent advances in mitochondrial replacement therapy and its future expectations |
| title_full_unstemmed | Recent advances in mitochondrial replacement therapy and its future expectations |
| title_short | Recent advances in mitochondrial replacement therapy and its future expectations |
| title_sort | recent advances in mitochondrial replacement therapy and its future expectations |
| topic | mitochondrial diseases mitochondrial replacement therapy (MRT) mtDNA |
| url | https://doi.org/10.1002/ctd2.70010 |
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