Beyond vision loss: the impact of glaucoma on the brain
Glaucoma, a leading cause of irreversible blindness, is characterized by optic disc cupping and retinal ganglion cell (RGC) degeneration. Recent research highlights the broader impacts of glaucoma on the brain. Transsynaptic neural degeneration extends the RGC damage through the visual pathway and v...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1588561/full |
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| author | Trinita Jude Hamilton Bettina E. Kalisch |
| author_facet | Trinita Jude Hamilton Bettina E. Kalisch |
| author_sort | Trinita Jude Hamilton |
| collection | DOAJ |
| description | Glaucoma, a leading cause of irreversible blindness, is characterized by optic disc cupping and retinal ganglion cell (RGC) degeneration. Recent research highlights the broader impacts of glaucoma on the brain. Transsynaptic neural degeneration extends the RGC damage through the visual pathway and various other regions in the brain, leading to structural and functional changes. These neurodegenerative effects may result in cognitive impairment, affecting patients’ daily activities and quality of life. Understanding the connection between glaucoma, the brain, and cognition is essential for intervention and developing comprehensive treatment strategies that address visual and neurological impairments, ultimately improving patient outcomes. This review examines the existing literature on the links between glaucoma pathology and the brain and explores the impacts on cognition and quality of life. |
| format | Article |
| id | doaj-art-cebb63c31b25401e8e7a3e51476a05e2 |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-cebb63c31b25401e8e7a3e51476a05e22025-08-20T03:56:17ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-07-011310.3389/fcell.2025.15885611588561Beyond vision loss: the impact of glaucoma on the brainTrinita Jude HamiltonBettina E. KalischGlaucoma, a leading cause of irreversible blindness, is characterized by optic disc cupping and retinal ganglion cell (RGC) degeneration. Recent research highlights the broader impacts of glaucoma on the brain. Transsynaptic neural degeneration extends the RGC damage through the visual pathway and various other regions in the brain, leading to structural and functional changes. These neurodegenerative effects may result in cognitive impairment, affecting patients’ daily activities and quality of life. Understanding the connection between glaucoma, the brain, and cognition is essential for intervention and developing comprehensive treatment strategies that address visual and neurological impairments, ultimately improving patient outcomes. This review examines the existing literature on the links between glaucoma pathology and the brain and explores the impacts on cognition and quality of life.https://www.frontiersin.org/articles/10.3389/fcell.2025.1588561/fullglaucomaneural degenerationcognitive impairmentoptic discretinal ganglion cell |
| spellingShingle | Trinita Jude Hamilton Bettina E. Kalisch Beyond vision loss: the impact of glaucoma on the brain Frontiers in Cell and Developmental Biology glaucoma neural degeneration cognitive impairment optic disc retinal ganglion cell |
| title | Beyond vision loss: the impact of glaucoma on the brain |
| title_full | Beyond vision loss: the impact of glaucoma on the brain |
| title_fullStr | Beyond vision loss: the impact of glaucoma on the brain |
| title_full_unstemmed | Beyond vision loss: the impact of glaucoma on the brain |
| title_short | Beyond vision loss: the impact of glaucoma on the brain |
| title_sort | beyond vision loss the impact of glaucoma on the brain |
| topic | glaucoma neural degeneration cognitive impairment optic disc retinal ganglion cell |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1588561/full |
| work_keys_str_mv | AT trinitajudehamilton beyondvisionlosstheimpactofglaucomaonthebrain AT bettinaekalisch beyondvisionlosstheimpactofglaucomaonthebrain |