Atherosclerotic Risk Factor Prevalence in Adults With Congenital Heart Disease
Background: The risk of atherosclerotic cardiovascular disease (ASCVD) in adults with congenital heart disease (ACHD) is comparable to that of the general population and is driven by traditional ASCVD risk factors. Objectives: The aim of the study was to estimate the prevalence of traditional ASCVD...
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Elsevier
2024-11-01
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| Series: | JACC: Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772963X24006392 |
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| author | Andreas S. Papazoglou, MD, MSc Konstantinos G. Kyriakoulis, MD, PhD Konstantinos Barmpagiannos, MD Dimitrios V. Moysidis, MD, MSc Anastasios Kartas, MD, PhD Maria Chatzi, MD, MSc Amalia Baroutidou, MD, MSc Vasileios Kamperidis, MD, PhD Antonios Ziakas, MD, PhD Konstantinos Dimopoulos, MD, PhD George Giannakoulas, MD, PhD |
| author_facet | Andreas S. Papazoglou, MD, MSc Konstantinos G. Kyriakoulis, MD, PhD Konstantinos Barmpagiannos, MD Dimitrios V. Moysidis, MD, MSc Anastasios Kartas, MD, PhD Maria Chatzi, MD, MSc Amalia Baroutidou, MD, MSc Vasileios Kamperidis, MD, PhD Antonios Ziakas, MD, PhD Konstantinos Dimopoulos, MD, PhD George Giannakoulas, MD, PhD |
| author_sort | Andreas S. Papazoglou, MD, MSc |
| collection | DOAJ |
| description | Background: The risk of atherosclerotic cardiovascular disease (ASCVD) in adults with congenital heart disease (ACHD) is comparable to that of the general population and is driven by traditional ASCVD risk factors. Objectives: The aim of the study was to estimate the prevalence of traditional ASCVD risk factors (hypertension, dyslipidemia, diabetes mellitus [DM], obesity, smoking, and physical inactivity) in ACHD and compare it with the general population. Methods: A systematic literature search was conducted up to May 15, 2024, to identify studies (with or without control group) reporting the prevalence of ASCVD risk factors in ACHD. Meta-analyses were conducted to synthesize the prevalence of risk factors and compare it with that of the general population, where applicable. Results: We identified 62 studies (30 controlled) encompassing 110,469 ACHD (mean age 39 years; 52% males, 88% with simple/moderate congenital heart disease complexity). Of these, 54% (45%-63%) reported lack of regular exercise, 33% (26%-40%) had hypertension, 18% (14%-22%) were obese, 17% (11%-25%) had dyslipidemia, 12% (9%-14%) were current smokers, and 7% (5%-9%) had DM. The prevalence of ASCVD risk factors was similar in ACHD and controls, with the exception of DM (higher prevalence in ACHD) and smoking (lower prevalence in ACHD). Significant heterogeneity was observed among the included studies, partially explained by differences in age, congenital heart disease complexity, and the presence of cyanosis. Conclusions: Except for DM and smoking, the prevalence of traditional ASCVD risk factors is similar in ACHD compared to the general population. Further research is needed to determine whether interventions applied in the general population are also effective in ACHD. |
| format | Article |
| id | doaj-art-ceb84dd91ee944c0b8c480ad4ccdcbe5 |
| institution | OA Journals |
| issn | 2772-963X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
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| series | JACC: Advances |
| spelling | doaj-art-ceb84dd91ee944c0b8c480ad4ccdcbe52025-08-20T02:17:37ZengElsevierJACC: Advances2772-963X2024-11-0131110135910.1016/j.jacadv.2024.101359Atherosclerotic Risk Factor Prevalence in Adults With Congenital Heart DiseaseAndreas S. Papazoglou, MD, MSc0Konstantinos G. Kyriakoulis, MD, PhD1Konstantinos Barmpagiannos, MD2Dimitrios V. Moysidis, MD, MSc3Anastasios Kartas, MD, PhD4Maria Chatzi, MD, MSc5Amalia Baroutidou, MD, MSc6Vasileios Kamperidis, MD, PhD7Antonios Ziakas, MD, PhD8Konstantinos Dimopoulos, MD, PhD9George Giannakoulas, MD, PhD10Athens Naval Hospital, Athens, GreeceNational and Kapodistrian University of Athens, School of Medicine, Athens, GreeceFirst Department of Cardiology, General University Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, Greece424 General Military Hospital of Thessaloniki, Thessaloniki, Greece424 General Military Hospital of Thessaloniki, Thessaloniki, GreeceAthens Naval Hospital, Athens, GreeceFirst Department of Cardiology, General University Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, GreeceFirst Department of Cardiology, General University Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, GreeceFirst Department of Cardiology, General University Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, GreeceAdult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United KingdomFirst Department of Cardiology, General University Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, Greece; Address for correspondence: Dr George Giannakoulas, First Department of Cardiology, Aristotle University of Thessaloniki, AHEPA University Hospital, St. Kiriakidi 1, 54636 Thessaloniki, Greece.Background: The risk of atherosclerotic cardiovascular disease (ASCVD) in adults with congenital heart disease (ACHD) is comparable to that of the general population and is driven by traditional ASCVD risk factors. Objectives: The aim of the study was to estimate the prevalence of traditional ASCVD risk factors (hypertension, dyslipidemia, diabetes mellitus [DM], obesity, smoking, and physical inactivity) in ACHD and compare it with the general population. Methods: A systematic literature search was conducted up to May 15, 2024, to identify studies (with or without control group) reporting the prevalence of ASCVD risk factors in ACHD. Meta-analyses were conducted to synthesize the prevalence of risk factors and compare it with that of the general population, where applicable. Results: We identified 62 studies (30 controlled) encompassing 110,469 ACHD (mean age 39 years; 52% males, 88% with simple/moderate congenital heart disease complexity). Of these, 54% (45%-63%) reported lack of regular exercise, 33% (26%-40%) had hypertension, 18% (14%-22%) were obese, 17% (11%-25%) had dyslipidemia, 12% (9%-14%) were current smokers, and 7% (5%-9%) had DM. The prevalence of ASCVD risk factors was similar in ACHD and controls, with the exception of DM (higher prevalence in ACHD) and smoking (lower prevalence in ACHD). Significant heterogeneity was observed among the included studies, partially explained by differences in age, congenital heart disease complexity, and the presence of cyanosis. Conclusions: Except for DM and smoking, the prevalence of traditional ASCVD risk factors is similar in ACHD compared to the general population. Further research is needed to determine whether interventions applied in the general population are also effective in ACHD.http://www.sciencedirect.com/science/article/pii/S2772963X24006392adultsatherosclerosiscongenital heart diseasecardiovascular preventionprevalencetraditional risk factors |
| spellingShingle | Andreas S. Papazoglou, MD, MSc Konstantinos G. Kyriakoulis, MD, PhD Konstantinos Barmpagiannos, MD Dimitrios V. Moysidis, MD, MSc Anastasios Kartas, MD, PhD Maria Chatzi, MD, MSc Amalia Baroutidou, MD, MSc Vasileios Kamperidis, MD, PhD Antonios Ziakas, MD, PhD Konstantinos Dimopoulos, MD, PhD George Giannakoulas, MD, PhD Atherosclerotic Risk Factor Prevalence in Adults With Congenital Heart Disease JACC: Advances adults atherosclerosis congenital heart disease cardiovascular prevention prevalence traditional risk factors |
| title | Atherosclerotic Risk Factor Prevalence in Adults With Congenital Heart Disease |
| title_full | Atherosclerotic Risk Factor Prevalence in Adults With Congenital Heart Disease |
| title_fullStr | Atherosclerotic Risk Factor Prevalence in Adults With Congenital Heart Disease |
| title_full_unstemmed | Atherosclerotic Risk Factor Prevalence in Adults With Congenital Heart Disease |
| title_short | Atherosclerotic Risk Factor Prevalence in Adults With Congenital Heart Disease |
| title_sort | atherosclerotic risk factor prevalence in adults with congenital heart disease |
| topic | adults atherosclerosis congenital heart disease cardiovascular prevention prevalence traditional risk factors |
| url | http://www.sciencedirect.com/science/article/pii/S2772963X24006392 |
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