The Battle between Infection and Host Immune Responses of Dengue Virus and Its Implication in Dengue Disease Pathogenesis
Dengue virus (DENV) is a mosquito-transmitted single stranded RNA virus belonging to genus Flavivirus. The virus is endemic in the tropical and subtropical countries of the world, causing diseases classified according to symptoms and severity (from mild to severe) as dengue fever, dengue hemorrhagic...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/843469 |
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| _version_ | 1850175380570243072 |
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| author | Peifang Sun Tadeusz J. Kochel |
| author_facet | Peifang Sun Tadeusz J. Kochel |
| author_sort | Peifang Sun |
| collection | DOAJ |
| description | Dengue virus (DENV) is a mosquito-transmitted single stranded RNA virus belonging to genus Flavivirus. The virus is endemic in the tropical and subtropical countries of the world, causing diseases classified according to symptoms and severity (from mild to severe) as dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. Among a variety of human cell types targeted by DENV, monocytes, macrophages, and dendritic cells are members of innate immunity, capable of mounting rapid inflammatory responses. These cells are also major antigen presenting cells, responsible for activating the adaptive immunity for long-term memory. This paper is an overview of the current understanding of the following mutually affected aspects: DENV structure, viral infectivity, cellular receptors, innate immune response, and adaptive immunity. |
| format | Article |
| id | doaj-art-ceb6ce88b0594ea9aacf30f1a6d3c19c |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-ceb6ce88b0594ea9aacf30f1a6d3c19c2025-08-20T02:19:29ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/843469843469The Battle between Infection and Host Immune Responses of Dengue Virus and Its Implication in Dengue Disease PathogenesisPeifang Sun0Tadeusz J. Kochel1Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USADepartment of Viral and Rickettsial Diseases, Naval Medical Research Center, Silver Spring, MD 20910, USADengue virus (DENV) is a mosquito-transmitted single stranded RNA virus belonging to genus Flavivirus. The virus is endemic in the tropical and subtropical countries of the world, causing diseases classified according to symptoms and severity (from mild to severe) as dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. Among a variety of human cell types targeted by DENV, monocytes, macrophages, and dendritic cells are members of innate immunity, capable of mounting rapid inflammatory responses. These cells are also major antigen presenting cells, responsible for activating the adaptive immunity for long-term memory. This paper is an overview of the current understanding of the following mutually affected aspects: DENV structure, viral infectivity, cellular receptors, innate immune response, and adaptive immunity.http://dx.doi.org/10.1155/2013/843469 |
| spellingShingle | Peifang Sun Tadeusz J. Kochel The Battle between Infection and Host Immune Responses of Dengue Virus and Its Implication in Dengue Disease Pathogenesis The Scientific World Journal |
| title | The Battle between Infection and Host Immune Responses of Dengue Virus and Its Implication in Dengue Disease Pathogenesis |
| title_full | The Battle between Infection and Host Immune Responses of Dengue Virus and Its Implication in Dengue Disease Pathogenesis |
| title_fullStr | The Battle between Infection and Host Immune Responses of Dengue Virus and Its Implication in Dengue Disease Pathogenesis |
| title_full_unstemmed | The Battle between Infection and Host Immune Responses of Dengue Virus and Its Implication in Dengue Disease Pathogenesis |
| title_short | The Battle between Infection and Host Immune Responses of Dengue Virus and Its Implication in Dengue Disease Pathogenesis |
| title_sort | battle between infection and host immune responses of dengue virus and its implication in dengue disease pathogenesis |
| url | http://dx.doi.org/10.1155/2013/843469 |
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