Tumor budding as an indicator of prognosis in locally advanced rectal cancer after neoadjuvant chemoradiotherapy: a systematic review and meta-analysis
IntroductionTumor budding (TB) is recognized as a complementary prognostic factor for colorectal cancer. However, data on its impact on the survival of patients undergoing neoadjuvant chemoradiotherapy (nCRT) remain limited. This study aims to investigate the role of TB in disease-free survival (DFS...
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| Format: | Article |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1429319/full |
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| author | Azita Rafiee Parto Nasri Afshin Moradi Paridokht Karimian |
| author_facet | Azita Rafiee Parto Nasri Afshin Moradi Paridokht Karimian |
| author_sort | Azita Rafiee |
| collection | DOAJ |
| description | IntroductionTumor budding (TB) is recognized as a complementary prognostic factor for colorectal cancer. However, data on its impact on the survival of patients undergoing neoadjuvant chemoradiotherapy (nCRT) remain limited. This study aims to investigate the role of TB in disease-free survival (DFS) and overall survival (OS) among patients with locally advanced rectal cancer receiving nCRT.MethodsIn this systematic review and meta-analysis, an exhaustive search of the PubMed, Scopus, Web of Science (WOS), Embase, and Cochrane databases was conducted, ultimately leading to the extraction of eight studies in the qualitative assessment and meta-analysis.ResultsAll the included studies were of high quality. The total sample size comprised 1,941 individuals. Although eight studies were included, nine datasets were extracted, as some studies reported multiple outcome measurements. TB positivity was statistically associated with decreased overall survival of 3.24 (95% confidence interval [CI]: 1.71–6.16) and disease-free survival of 2.54 (95% CI: 1.56–4.15) in patients with locally advanced rectal cancer undergoing nCRT.DiscussionBased on the findings of this study, TB negativity was statistically and directly associated with better OS and DFS in patients with locally advanced rectal cancer undergoing nCRT. |
| format | Article |
| id | doaj-art-ceb5937ac8624c1a9849d2db79e132ce |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-ceb5937ac8624c1a9849d2db79e132ce2025-08-20T03:06:13ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-04-011510.3389/fonc.2025.14293191429319Tumor budding as an indicator of prognosis in locally advanced rectal cancer after neoadjuvant chemoradiotherapy: a systematic review and meta-analysisAzita Rafiee0Parto Nasri1Afshin Moradi2Paridokht Karimian3Department of Pathology, Iranian Medical and Pathology Laboratory, Zahedan, IranDepartment of Pathology, Isfahan University of Medical Sciences, Isfahan, IranCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Pathology, School of Medicine, Guilan University of Medical Sciences, Rasht, IranIntroductionTumor budding (TB) is recognized as a complementary prognostic factor for colorectal cancer. However, data on its impact on the survival of patients undergoing neoadjuvant chemoradiotherapy (nCRT) remain limited. This study aims to investigate the role of TB in disease-free survival (DFS) and overall survival (OS) among patients with locally advanced rectal cancer receiving nCRT.MethodsIn this systematic review and meta-analysis, an exhaustive search of the PubMed, Scopus, Web of Science (WOS), Embase, and Cochrane databases was conducted, ultimately leading to the extraction of eight studies in the qualitative assessment and meta-analysis.ResultsAll the included studies were of high quality. The total sample size comprised 1,941 individuals. Although eight studies were included, nine datasets were extracted, as some studies reported multiple outcome measurements. TB positivity was statistically associated with decreased overall survival of 3.24 (95% confidence interval [CI]: 1.71–6.16) and disease-free survival of 2.54 (95% CI: 1.56–4.15) in patients with locally advanced rectal cancer undergoing nCRT.DiscussionBased on the findings of this study, TB negativity was statistically and directly associated with better OS and DFS in patients with locally advanced rectal cancer undergoing nCRT.https://www.frontiersin.org/articles/10.3389/fonc.2025.1429319/fullrectal neoplasmneoadjuvant therapytumor buddingprognosiscolon cancer |
| spellingShingle | Azita Rafiee Parto Nasri Afshin Moradi Paridokht Karimian Tumor budding as an indicator of prognosis in locally advanced rectal cancer after neoadjuvant chemoradiotherapy: a systematic review and meta-analysis Frontiers in Oncology rectal neoplasm neoadjuvant therapy tumor budding prognosis colon cancer |
| title | Tumor budding as an indicator of prognosis in locally advanced rectal cancer after neoadjuvant chemoradiotherapy: a systematic review and meta-analysis |
| title_full | Tumor budding as an indicator of prognosis in locally advanced rectal cancer after neoadjuvant chemoradiotherapy: a systematic review and meta-analysis |
| title_fullStr | Tumor budding as an indicator of prognosis in locally advanced rectal cancer after neoadjuvant chemoradiotherapy: a systematic review and meta-analysis |
| title_full_unstemmed | Tumor budding as an indicator of prognosis in locally advanced rectal cancer after neoadjuvant chemoradiotherapy: a systematic review and meta-analysis |
| title_short | Tumor budding as an indicator of prognosis in locally advanced rectal cancer after neoadjuvant chemoradiotherapy: a systematic review and meta-analysis |
| title_sort | tumor budding as an indicator of prognosis in locally advanced rectal cancer after neoadjuvant chemoradiotherapy a systematic review and meta analysis |
| topic | rectal neoplasm neoadjuvant therapy tumor budding prognosis colon cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1429319/full |
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