Impact of Congenital Heart Disease on Brain Development and Neurodevelopmental Outcome
Advances in cardiac surgical techniques and perioperative intensive care have led to improved survival in babies with congenital heart disease (CHD). While it is true that the majority of children with CHD today will survive, many will have impaired neurodevelopmental outcome across a wide spectrum...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2010/359390 |
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| _version_ | 1832551979884216320 |
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| author | Mary T. Donofrio An N. Massaro |
| author_facet | Mary T. Donofrio An N. Massaro |
| author_sort | Mary T. Donofrio |
| collection | DOAJ |
| description | Advances in cardiac surgical techniques and perioperative intensive care have led to improved survival in babies with congenital heart disease (CHD). While it is true that the majority of children with CHD today will survive, many will have impaired neurodevelopmental outcome across a wide spectrum of domains. While continuing to improve short-term morbidity and mortality is an important goal, recent and ongoing research has focused on defining the impact of CHD on brain development, minimizing postnatal brain injury, and improving long-term outcomes. This paper will review the impact that CHD has on the developing brain of the fetus and infant. Neurologic abnormalities detectable prior to surgery will be described. Potential etiologies of these findings will be discussed, including altered fetal intrauterine growth, cerebral blood flow and brain development, associated congenital brain abnormalities, and risk for postnatal brain injury. Finally, reported neurodevelopmental outcomes after surgical repair of CHD will be reviewed. |
| format | Article |
| id | doaj-art-ceb2e558b66f435eb0e503c37fe07525 |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-ceb2e558b66f435eb0e503c37fe075252025-02-03T06:00:01ZengWileyInternational Journal of Pediatrics1687-97401687-97592010-01-01201010.1155/2010/359390359390Impact of Congenital Heart Disease on Brain Development and Neurodevelopmental OutcomeMary T. Donofrio0An N. Massaro1Children's National Heart Institute, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USAChildren's National Heart Institute, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USAAdvances in cardiac surgical techniques and perioperative intensive care have led to improved survival in babies with congenital heart disease (CHD). While it is true that the majority of children with CHD today will survive, many will have impaired neurodevelopmental outcome across a wide spectrum of domains. While continuing to improve short-term morbidity and mortality is an important goal, recent and ongoing research has focused on defining the impact of CHD on brain development, minimizing postnatal brain injury, and improving long-term outcomes. This paper will review the impact that CHD has on the developing brain of the fetus and infant. Neurologic abnormalities detectable prior to surgery will be described. Potential etiologies of these findings will be discussed, including altered fetal intrauterine growth, cerebral blood flow and brain development, associated congenital brain abnormalities, and risk for postnatal brain injury. Finally, reported neurodevelopmental outcomes after surgical repair of CHD will be reviewed.http://dx.doi.org/10.1155/2010/359390 |
| spellingShingle | Mary T. Donofrio An N. Massaro Impact of Congenital Heart Disease on Brain Development and Neurodevelopmental Outcome International Journal of Pediatrics |
| title | Impact of Congenital Heart Disease on Brain Development and Neurodevelopmental Outcome |
| title_full | Impact of Congenital Heart Disease on Brain Development and Neurodevelopmental Outcome |
| title_fullStr | Impact of Congenital Heart Disease on Brain Development and Neurodevelopmental Outcome |
| title_full_unstemmed | Impact of Congenital Heart Disease on Brain Development and Neurodevelopmental Outcome |
| title_short | Impact of Congenital Heart Disease on Brain Development and Neurodevelopmental Outcome |
| title_sort | impact of congenital heart disease on brain development and neurodevelopmental outcome |
| url | http://dx.doi.org/10.1155/2010/359390 |
| work_keys_str_mv | AT marytdonofrio impactofcongenitalheartdiseaseonbraindevelopmentandneurodevelopmentaloutcome AT annmassaro impactofcongenitalheartdiseaseonbraindevelopmentandneurodevelopmentaloutcome |