IL-32: A Novel Pluripotent Inflammatory Interleukin, towards Gastric Inflammation, Gastric Cancer, and Chronic Rhino Sinusitis
A vast variety of nonstructural proteins have been studied for their key roles and involvement in a number of biological phenomenona. Interleukin-32 is a novel cytokine whose presence has been confirmed in most of the mammals except rodents. The IL-32 gene was identified on human chromosome 16 p13.3...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/8413768 |
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| author | Muhammad Babar Khawar Muddasir Hassan Abbasi Nadeem Sheikh |
| author_facet | Muhammad Babar Khawar Muddasir Hassan Abbasi Nadeem Sheikh |
| author_sort | Muhammad Babar Khawar |
| collection | DOAJ |
| description | A vast variety of nonstructural proteins have been studied for their key roles and involvement in a number of biological phenomenona. Interleukin-32 is a novel cytokine whose presence has been confirmed in most of the mammals except rodents. The IL-32 gene was identified on human chromosome 16 p13.3. The gene has eight exons and nine splice variants, namely, IL-32α, IL-32β, IL-32γ, IL-32δ, IL-32ε, IL-32ζ, IL-32η, IL-32θ, and IL-32s. It was found to induce the expression of various inflammatory cytokines including TNF-α, IL-6, and IL-1β as well as macrophage inflammatory protein-2 (MIP-2) and has been reported previously to be involved in the pathogenesis and progression of a number of inflammatory disorders, namely, inflammatory bowel disease (IBD), gastric inflammation and cancer, rheumatoid arthritis, and chronic obstructive pulmonary disease (COPD). In the current review, we have highlighted the involvement of IL-32 in gastric cancer, gastric inflammation, and chronic rhinosinusitis. We have also tried to explore various mechanisms suspected to induce the expression of this extraordinary cytokine as well as various mechanisms of action employed by IL-32 during the mediation and progression of the above said problems. |
| format | Article |
| id | doaj-art-cea66394230743e4b98fe496abb4580e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-cea66394230743e4b98fe496abb4580e2025-02-03T01:32:54ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/84137688413768IL-32: A Novel Pluripotent Inflammatory Interleukin, towards Gastric Inflammation, Gastric Cancer, and Chronic Rhino SinusitisMuhammad Babar Khawar0Muddasir Hassan Abbasi1Nadeem Sheikh2Cell and Molecular Biology Lab, Department of Zoology, University of the Punjab, Lahore 54590, PakistanCell and Molecular Biology Lab, Department of Zoology, University of the Punjab, Lahore 54590, PakistanCell and Molecular Biology Lab, Department of Zoology, University of the Punjab, Lahore 54590, PakistanA vast variety of nonstructural proteins have been studied for their key roles and involvement in a number of biological phenomenona. Interleukin-32 is a novel cytokine whose presence has been confirmed in most of the mammals except rodents. The IL-32 gene was identified on human chromosome 16 p13.3. The gene has eight exons and nine splice variants, namely, IL-32α, IL-32β, IL-32γ, IL-32δ, IL-32ε, IL-32ζ, IL-32η, IL-32θ, and IL-32s. It was found to induce the expression of various inflammatory cytokines including TNF-α, IL-6, and IL-1β as well as macrophage inflammatory protein-2 (MIP-2) and has been reported previously to be involved in the pathogenesis and progression of a number of inflammatory disorders, namely, inflammatory bowel disease (IBD), gastric inflammation and cancer, rheumatoid arthritis, and chronic obstructive pulmonary disease (COPD). In the current review, we have highlighted the involvement of IL-32 in gastric cancer, gastric inflammation, and chronic rhinosinusitis. We have also tried to explore various mechanisms suspected to induce the expression of this extraordinary cytokine as well as various mechanisms of action employed by IL-32 during the mediation and progression of the above said problems.http://dx.doi.org/10.1155/2016/8413768 |
| spellingShingle | Muhammad Babar Khawar Muddasir Hassan Abbasi Nadeem Sheikh IL-32: A Novel Pluripotent Inflammatory Interleukin, towards Gastric Inflammation, Gastric Cancer, and Chronic Rhino Sinusitis Mediators of Inflammation |
| title | IL-32: A Novel Pluripotent Inflammatory Interleukin, towards Gastric Inflammation, Gastric Cancer, and Chronic Rhino Sinusitis |
| title_full | IL-32: A Novel Pluripotent Inflammatory Interleukin, towards Gastric Inflammation, Gastric Cancer, and Chronic Rhino Sinusitis |
| title_fullStr | IL-32: A Novel Pluripotent Inflammatory Interleukin, towards Gastric Inflammation, Gastric Cancer, and Chronic Rhino Sinusitis |
| title_full_unstemmed | IL-32: A Novel Pluripotent Inflammatory Interleukin, towards Gastric Inflammation, Gastric Cancer, and Chronic Rhino Sinusitis |
| title_short | IL-32: A Novel Pluripotent Inflammatory Interleukin, towards Gastric Inflammation, Gastric Cancer, and Chronic Rhino Sinusitis |
| title_sort | il 32 a novel pluripotent inflammatory interleukin towards gastric inflammation gastric cancer and chronic rhino sinusitis |
| url | http://dx.doi.org/10.1155/2016/8413768 |
| work_keys_str_mv | AT muhammadbabarkhawar il32anovelpluripotentinflammatoryinterleukintowardsgastricinflammationgastriccancerandchronicrhinosinusitis AT muddasirhassanabbasi il32anovelpluripotentinflammatoryinterleukintowardsgastricinflammationgastriccancerandchronicrhinosinusitis AT nadeemsheikh il32anovelpluripotentinflammatoryinterleukintowardsgastricinflammationgastriccancerandchronicrhinosinusitis |