Prognostic significance of mean platelet volume to platelet count ratio in pediatric patients with acute kidney injury
Background. Mean platelet volume (MPV), which is regarded as a marker of thrombocyte function and activation, is related to increased morbidity and mortality. In critically ill patients, the ratio of MPV to platelets can independently predict adverse outcomes. This study aimed to investigate the pr...
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Hacettepe University Institute of Child Health
2024-07-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/4514 |
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| author | Kübra Çeleğen Mehmet Çeleğen |
| author_facet | Kübra Çeleğen Mehmet Çeleğen |
| author_sort | Kübra Çeleğen |
| collection | DOAJ |
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Background. Mean platelet volume (MPV), which is regarded as a marker of thrombocyte function and activation, is related to increased morbidity and mortality. In critically ill patients, the ratio of MPV to platelets can independently predict adverse outcomes. This study aimed to investigate the prognostic value of the mean platelet volume/platelet count ratio (MPR) for mortality in children with acute kidney injury (AKI).
Methods. In this retrospective study, patients hospitalized in the pediatric intensive care unit (PICU) between March 2020 and June 2022 were evaluated. Patients between 1 month and 18 years of age with AKI were enrolled. Clinical and laboratory data were compared between survivors and non-survivors. The MPR ratio was calculated on the first and third days of admission to the intensive care unit. A multiple logistic regression analysis was used to determine the association between MPR and mortality. ROC curves were used for the prediction performance of the logistic regression models and cut-off values of the thrombocyte indices.
Results. Sixty-three children with AKI were included in the study. The total mortality rate was 34.9% (n=22). MPR ratios were significantly higher in the non-survivors at admission (p=0.042) and at the 72nd hour (p=0.003). In the multiple logistic regression analysis, thrombocyte counts and MPR72h ratio were found to be independent risk parameters for adverse outcomes in children with AKI.
Conclusions. MPR is an inexpensive and practical marker that may predict the outcome of children with AKI.
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| format | Article |
| id | doaj-art-ce9fd9a7a439491291946d300c2c64e5 |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-ce9fd9a7a439491291946d300c2c64e52025-08-20T02:17:57ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212024-07-0166310.24953/turkjpediatr.2024.4514Prognostic significance of mean platelet volume to platelet count ratio in pediatric patients with acute kidney injuryKübra Çeleğen0https://orcid.org/0000-0003-2178-2788Mehmet Çeleğen1https://orcid.org/0000-0002-6841-3675Division of Pediatric Nephrology, Department of Pediatrics, Afyonkarahisar Health Sciences University Faculty of Medicine, Afyonkarahisar, TürkiyeDivision of Pediatric Intensive Care Unit, Department of Pediatrics, Afyonkarahisar Health Sciences University Faculty of Medicine, Afyonkarahisar, Türkiye Background. Mean platelet volume (MPV), which is regarded as a marker of thrombocyte function and activation, is related to increased morbidity and mortality. In critically ill patients, the ratio of MPV to platelets can independently predict adverse outcomes. This study aimed to investigate the prognostic value of the mean platelet volume/platelet count ratio (MPR) for mortality in children with acute kidney injury (AKI). Methods. In this retrospective study, patients hospitalized in the pediatric intensive care unit (PICU) between March 2020 and June 2022 were evaluated. Patients between 1 month and 18 years of age with AKI were enrolled. Clinical and laboratory data were compared between survivors and non-survivors. The MPR ratio was calculated on the first and third days of admission to the intensive care unit. A multiple logistic regression analysis was used to determine the association between MPR and mortality. ROC curves were used for the prediction performance of the logistic regression models and cut-off values of the thrombocyte indices. Results. Sixty-three children with AKI were included in the study. The total mortality rate was 34.9% (n=22). MPR ratios were significantly higher in the non-survivors at admission (p=0.042) and at the 72nd hour (p=0.003). In the multiple logistic regression analysis, thrombocyte counts and MPR72h ratio were found to be independent risk parameters for adverse outcomes in children with AKI. Conclusions. MPR is an inexpensive and practical marker that may predict the outcome of children with AKI. https://turkjpediatr.org/article/view/4514acute kidney injurymortalitymean platelet volumeplatelet countmean platelet volume platelet count ratiochildren |
| spellingShingle | Kübra Çeleğen Mehmet Çeleğen Prognostic significance of mean platelet volume to platelet count ratio in pediatric patients with acute kidney injury The Turkish Journal of Pediatrics acute kidney injury mortality mean platelet volume platelet count mean platelet volume platelet count ratio children |
| title | Prognostic significance of mean platelet volume to platelet count ratio in pediatric patients with acute kidney injury |
| title_full | Prognostic significance of mean platelet volume to platelet count ratio in pediatric patients with acute kidney injury |
| title_fullStr | Prognostic significance of mean platelet volume to platelet count ratio in pediatric patients with acute kidney injury |
| title_full_unstemmed | Prognostic significance of mean platelet volume to platelet count ratio in pediatric patients with acute kidney injury |
| title_short | Prognostic significance of mean platelet volume to platelet count ratio in pediatric patients with acute kidney injury |
| title_sort | prognostic significance of mean platelet volume to platelet count ratio in pediatric patients with acute kidney injury |
| topic | acute kidney injury mortality mean platelet volume platelet count mean platelet volume platelet count ratio children |
| url | https://turkjpediatr.org/article/view/4514 |
| work_keys_str_mv | AT kubracelegen prognosticsignificanceofmeanplateletvolumetoplateletcountratioinpediatricpatientswithacutekidneyinjury AT mehmetcelegen prognosticsignificanceofmeanplateletvolumetoplateletcountratioinpediatricpatientswithacutekidneyinjury |