Association of neonatal and fetal malformations with polyhydramnios and oligohydramnios - introduction of a new “association factor”
Abstract Background Our aim was to investigate the association of different neonatal and fetal anatomical abnormalities with polyhydramnios or oligohydramnios during prenatal ultrasonography. Methods In our study, we processed prenatal sonographic and postnatal neonatal clinical and pathological dat...
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BMC
2025-07-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-025-07797-5 |
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| author | Artur Beke Aténé Simonyi |
| author_facet | Artur Beke Aténé Simonyi |
| author_sort | Artur Beke |
| collection | DOAJ |
| description | Abstract Background Our aim was to investigate the association of different neonatal and fetal anatomical abnormalities with polyhydramnios or oligohydramnios during prenatal ultrasonography. Methods In our study, we processed prenatal sonographic and postnatal neonatal clinical and pathological data from 2,622 fetuses with malformations over a 12-year period. We investigated the association of neonatal and fetal abnormalities with polyhydramnios or oligohydramnios. To characterize the prevalence of association between a given disorder and polyhydramnios or oligohydramnios, we used our proprietary “association factor” (AF) for statistical calculations. Results Amniotic fluid volume abnormalities were most frequently detected in urogenital, abdominal, and abdominal wall anomalies. In urogenital anomalies, amniotic fluid volume abnormalities were found in more than half of the fetuses, 54.86% (oligohydramnios 34.72%, polyhydramnios 20.14%). In abdominal and abdominal wall anomalies, 43.82% of fetuses had abnormalities in the volume of amniotic fluid (polyhydramnios 31.44%, oligohydramnios 12.38%). Overall, we found abnormalities in the volume of amniotic fluid in over 30% of the fetuses with craniospinal, thoracic and pulmonary anomalies, limb anomalies, and ossification disorders. In craniofacial and cardiovascular anomalies, amniotic fluid volume abnormalities were only detectable in around 20%. For polyhydramnios, the “Association Factor” (AF) was very high for craniospinal, abdominal, and abdominal wall disorders, and it was high for cardiovascular, urogenital, limb, and ossification disorders. For oligohydramnios, the association factor (AF) was very high for urogenital disorders. Conclusions If the amniotic fluid volume during ultrasonography is less or more than average, special attention should be paid to the ultrasound examination of the fetus’ urogenital system, abdominal organs, skull, spine, chest, lungs, as well as limbs and skeletal system. In the case of polyhydramnios, fetal echocardiography is recommended. |
| format | Article |
| id | doaj-art-ce9ee695938c42ec82d66ffdb4d8531c |
| institution | Kabale University |
| issn | 1471-2393 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj-art-ce9ee695938c42ec82d66ffdb4d8531c2025-08-20T03:42:02ZengBMCBMC Pregnancy and Childbirth1471-23932025-07-0125111410.1186/s12884-025-07797-5Association of neonatal and fetal malformations with polyhydramnios and oligohydramnios - introduction of a new “association factor”Artur Beke0Aténé Simonyi1Department of Obstetrics and Gynecology, Semmelweis UniversityDepartment of Obstetrics and Gynecology, Semmelweis UniversityAbstract Background Our aim was to investigate the association of different neonatal and fetal anatomical abnormalities with polyhydramnios or oligohydramnios during prenatal ultrasonography. Methods In our study, we processed prenatal sonographic and postnatal neonatal clinical and pathological data from 2,622 fetuses with malformations over a 12-year period. We investigated the association of neonatal and fetal abnormalities with polyhydramnios or oligohydramnios. To characterize the prevalence of association between a given disorder and polyhydramnios or oligohydramnios, we used our proprietary “association factor” (AF) for statistical calculations. Results Amniotic fluid volume abnormalities were most frequently detected in urogenital, abdominal, and abdominal wall anomalies. In urogenital anomalies, amniotic fluid volume abnormalities were found in more than half of the fetuses, 54.86% (oligohydramnios 34.72%, polyhydramnios 20.14%). In abdominal and abdominal wall anomalies, 43.82% of fetuses had abnormalities in the volume of amniotic fluid (polyhydramnios 31.44%, oligohydramnios 12.38%). Overall, we found abnormalities in the volume of amniotic fluid in over 30% of the fetuses with craniospinal, thoracic and pulmonary anomalies, limb anomalies, and ossification disorders. In craniofacial and cardiovascular anomalies, amniotic fluid volume abnormalities were only detectable in around 20%. For polyhydramnios, the “Association Factor” (AF) was very high for craniospinal, abdominal, and abdominal wall disorders, and it was high for cardiovascular, urogenital, limb, and ossification disorders. For oligohydramnios, the association factor (AF) was very high for urogenital disorders. Conclusions If the amniotic fluid volume during ultrasonography is less or more than average, special attention should be paid to the ultrasound examination of the fetus’ urogenital system, abdominal organs, skull, spine, chest, lungs, as well as limbs and skeletal system. In the case of polyhydramnios, fetal echocardiography is recommended.https://doi.org/10.1186/s12884-025-07797-5Neonatal malformationsFetal structural abnormalitiesUltrasoundPolyhydramniosOligohydramnios |
| spellingShingle | Artur Beke Aténé Simonyi Association of neonatal and fetal malformations with polyhydramnios and oligohydramnios - introduction of a new “association factor” BMC Pregnancy and Childbirth Neonatal malformations Fetal structural abnormalities Ultrasound Polyhydramnios Oligohydramnios |
| title | Association of neonatal and fetal malformations with polyhydramnios and oligohydramnios - introduction of a new “association factor” |
| title_full | Association of neonatal and fetal malformations with polyhydramnios and oligohydramnios - introduction of a new “association factor” |
| title_fullStr | Association of neonatal and fetal malformations with polyhydramnios and oligohydramnios - introduction of a new “association factor” |
| title_full_unstemmed | Association of neonatal and fetal malformations with polyhydramnios and oligohydramnios - introduction of a new “association factor” |
| title_short | Association of neonatal and fetal malformations with polyhydramnios and oligohydramnios - introduction of a new “association factor” |
| title_sort | association of neonatal and fetal malformations with polyhydramnios and oligohydramnios introduction of a new association factor |
| topic | Neonatal malformations Fetal structural abnormalities Ultrasound Polyhydramnios Oligohydramnios |
| url | https://doi.org/10.1186/s12884-025-07797-5 |
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