SAFETY OF BIOLOGICAL PREPARATIONS AND SMALL MOLECULES. ARE THERE ANY DIFFERENCES?
A considerable number of biopharmaceuticals have recently been introduced into clinical practice. Their role is becoming more and more important in managing various diseases, including incapacitating and life-threatening diseases. The authors systematically reviewed literary data from 1990 to 2013 d...
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| Format: | Article |
| Language: | Russian |
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Union of pediatricians of Russia
2013-05-01
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| Series: | Педиатрическая фармакология |
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| Online Access: | https://www.pedpharma.ru/jour/article/view/215 |
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| author | A. S. Kolbin A. V. Kharchev |
| author_facet | A. S. Kolbin A. V. Kharchev |
| author_sort | A. S. Kolbin |
| collection | DOAJ |
| description | A considerable number of biopharmaceuticals have recently been introduced into clinical practice. Their role is becoming more and more important in managing various diseases, including incapacitating and life-threatening diseases. The authors systematically reviewed literary data from 1990 to 2013 dedicated to studying adverse side reactions to medicinal proteins. The authors used international databases to search for publications dedicated to this issue. As a result, this analysis involves studies describing adverse reactions of such biopharmaceuticals as immunosuppressants and antineoplastic agents. Differences between biopharmaceuticals and small molecules in the rate of adverse phenomena, structure and severity of their manifestations are shown. Classification of adverse reactions and possibility of its use in terms of biopharmaceuticals, recommendations and conclusions for the Russian pharmacovigilance system are given. |
| format | Article |
| id | doaj-art-ce9835dd1e294d609522eea761a0c235 |
| institution | DOAJ |
| issn | 1727-5776 2500-3089 |
| language | Russian |
| publishDate | 2013-05-01 |
| publisher | Union of pediatricians of Russia |
| record_format | Article |
| series | Педиатрическая фармакология |
| spelling | doaj-art-ce9835dd1e294d609522eea761a0c2352025-08-20T02:54:33ZrusUnion of pediatricians of RussiaПедиатрическая фармакология1727-57762500-30892013-05-01103172510.15690/pf.v10i3.693215SAFETY OF BIOLOGICAL PREPARATIONS AND SMALL MOLECULES. ARE THERE ANY DIFFERENCES?A. S. Kolbin0A. V. Kharchev1Saint Petersburg State University, Russian Federation Regional Drug Safety Monitoring Center, Saint Petersburg, Russian FederationSaint Petersburg State Pediatric Medical University, Russian FederationA considerable number of biopharmaceuticals have recently been introduced into clinical practice. Their role is becoming more and more important in managing various diseases, including incapacitating and life-threatening diseases. The authors systematically reviewed literary data from 1990 to 2013 dedicated to studying adverse side reactions to medicinal proteins. The authors used international databases to search for publications dedicated to this issue. As a result, this analysis involves studies describing adverse reactions of such biopharmaceuticals as immunosuppressants and antineoplastic agents. Differences between biopharmaceuticals and small molecules in the rate of adverse phenomena, structure and severity of their manifestations are shown. Classification of adverse reactions and possibility of its use in terms of biopharmaceuticals, recommendations and conclusions for the Russian pharmacovigilance system are given.https://www.pedpharma.ru/jour/article/view/215pharmacovigilancebiopharmaceuticalsafetyadverse side reactions and phenomena |
| spellingShingle | A. S. Kolbin A. V. Kharchev SAFETY OF BIOLOGICAL PREPARATIONS AND SMALL MOLECULES. ARE THERE ANY DIFFERENCES? Педиатрическая фармакология pharmacovigilance biopharmaceutical safety adverse side reactions and phenomena |
| title | SAFETY OF BIOLOGICAL PREPARATIONS AND SMALL MOLECULES. ARE THERE ANY DIFFERENCES? |
| title_full | SAFETY OF BIOLOGICAL PREPARATIONS AND SMALL MOLECULES. ARE THERE ANY DIFFERENCES? |
| title_fullStr | SAFETY OF BIOLOGICAL PREPARATIONS AND SMALL MOLECULES. ARE THERE ANY DIFFERENCES? |
| title_full_unstemmed | SAFETY OF BIOLOGICAL PREPARATIONS AND SMALL MOLECULES. ARE THERE ANY DIFFERENCES? |
| title_short | SAFETY OF BIOLOGICAL PREPARATIONS AND SMALL MOLECULES. ARE THERE ANY DIFFERENCES? |
| title_sort | safety of biological preparations and small molecules are there any differences |
| topic | pharmacovigilance biopharmaceutical safety adverse side reactions and phenomena |
| url | https://www.pedpharma.ru/jour/article/view/215 |
| work_keys_str_mv | AT askolbin safetyofbiologicalpreparationsandsmallmoleculesarethereanydifferences AT avkharchev safetyofbiologicalpreparationsandsmallmoleculesarethereanydifferences |