Marginal zone lymphoma of mucosa associated lymphoid tissue-lymphoma of the lacrimal gland in a young patient with Klinefelter syndrome: a case report
Abstract Background Klinefelter syndrome is considered one of the most common sex chromosome disorders affecting males. The presence of an extra X chromosome can alter the tendency to develop various cancers, including lymphomas. Lacrimal gland lymphoma is a disease of the elderly, with a median age...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-12-01
|
| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-024-04996-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850085956123623424 |
|---|---|
| author | Askar K. Alshaibani Reem R. Alanazi Bedour Akif Aleid Saad M. Alosaimi |
| author_facet | Askar K. Alshaibani Reem R. Alanazi Bedour Akif Aleid Saad M. Alosaimi |
| author_sort | Askar K. Alshaibani |
| collection | DOAJ |
| description | Abstract Background Klinefelter syndrome is considered one of the most common sex chromosome disorders affecting males. The presence of an extra X chromosome can alter the tendency to develop various cancers, including lymphomas. Lacrimal gland lymphoma is a disease of the elderly, with a median age of presentation of 70 years. Case presentation In this article, we report a case of a 35-year-old Arabian Saudi male with a known case of Klinefelter syndrome who presented to oculoplastic clinic complaining of progressively growing superior-temporal mass in the left eye. After evaluation and imaging, an incisional biopsy from the lacrimal gland mass was obtained and histopathological evaluation showed atypical lymphoproliferative infiltrate consistent with extranodal marginal zone lymphoma of mucosa associated lymphoid tissue. The mainstay treatment was external beam radiotherapy, which showed significant improvement in the case. Conclusion This is considered the first reported case of lacrimal gland lymphoma in young patient with Klinefelter syndrome, which increases the association between Klinefelter syndrome and lymphomas. |
| format | Article |
| id | doaj-art-ce97a787cc4e4b7189c3f9a429b7565f |
| institution | DOAJ |
| issn | 1752-1947 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj-art-ce97a787cc4e4b7189c3f9a429b7565f2025-08-20T02:43:36ZengBMCJournal of Medical Case Reports1752-19472024-12-011811510.1186/s13256-024-04996-0Marginal zone lymphoma of mucosa associated lymphoid tissue-lymphoma of the lacrimal gland in a young patient with Klinefelter syndrome: a case reportAskar K. Alshaibani0Reem R. Alanazi1Bedour Akif Aleid2Saad M. Alosaimi3Dhahran Eye Specialist HospitalDepartment of Ophthalmology, College of Medicine, King Fahad Hospital of the University, Imam Abdulrahman Bin Faisal UniversityDhahran Eye Specialist HospitalMinistry of HealthAbstract Background Klinefelter syndrome is considered one of the most common sex chromosome disorders affecting males. The presence of an extra X chromosome can alter the tendency to develop various cancers, including lymphomas. Lacrimal gland lymphoma is a disease of the elderly, with a median age of presentation of 70 years. Case presentation In this article, we report a case of a 35-year-old Arabian Saudi male with a known case of Klinefelter syndrome who presented to oculoplastic clinic complaining of progressively growing superior-temporal mass in the left eye. After evaluation and imaging, an incisional biopsy from the lacrimal gland mass was obtained and histopathological evaluation showed atypical lymphoproliferative infiltrate consistent with extranodal marginal zone lymphoma of mucosa associated lymphoid tissue. The mainstay treatment was external beam radiotherapy, which showed significant improvement in the case. Conclusion This is considered the first reported case of lacrimal gland lymphoma in young patient with Klinefelter syndrome, which increases the association between Klinefelter syndrome and lymphomas.https://doi.org/10.1186/s13256-024-04996-0Lacrimal glandLymphomaKlinefelter syndrome |
| spellingShingle | Askar K. Alshaibani Reem R. Alanazi Bedour Akif Aleid Saad M. Alosaimi Marginal zone lymphoma of mucosa associated lymphoid tissue-lymphoma of the lacrimal gland in a young patient with Klinefelter syndrome: a case report Journal of Medical Case Reports Lacrimal gland Lymphoma Klinefelter syndrome |
| title | Marginal zone lymphoma of mucosa associated lymphoid tissue-lymphoma of the lacrimal gland in a young patient with Klinefelter syndrome: a case report |
| title_full | Marginal zone lymphoma of mucosa associated lymphoid tissue-lymphoma of the lacrimal gland in a young patient with Klinefelter syndrome: a case report |
| title_fullStr | Marginal zone lymphoma of mucosa associated lymphoid tissue-lymphoma of the lacrimal gland in a young patient with Klinefelter syndrome: a case report |
| title_full_unstemmed | Marginal zone lymphoma of mucosa associated lymphoid tissue-lymphoma of the lacrimal gland in a young patient with Klinefelter syndrome: a case report |
| title_short | Marginal zone lymphoma of mucosa associated lymphoid tissue-lymphoma of the lacrimal gland in a young patient with Klinefelter syndrome: a case report |
| title_sort | marginal zone lymphoma of mucosa associated lymphoid tissue lymphoma of the lacrimal gland in a young patient with klinefelter syndrome a case report |
| topic | Lacrimal gland Lymphoma Klinefelter syndrome |
| url | https://doi.org/10.1186/s13256-024-04996-0 |
| work_keys_str_mv | AT askarkalshaibani marginalzonelymphomaofmucosaassociatedlymphoidtissuelymphomaofthelacrimalglandinayoungpatientwithklinefeltersyndromeacasereport AT reemralanazi marginalzonelymphomaofmucosaassociatedlymphoidtissuelymphomaofthelacrimalglandinayoungpatientwithklinefeltersyndromeacasereport AT bedourakifaleid marginalzonelymphomaofmucosaassociatedlymphoidtissuelymphomaofthelacrimalglandinayoungpatientwithklinefeltersyndromeacasereport AT saadmalosaimi marginalzonelymphomaofmucosaassociatedlymphoidtissuelymphomaofthelacrimalglandinayoungpatientwithklinefeltersyndromeacasereport |