Tailored Fluorescent Metal–Organic Frameworks Hybrid Membrane Sensor Arrays: Simultaneous and Selective Quantification of Multiple Antibiotics
Abstract Sensor array offers significant potential for rapid, high‐throughput antibiotic detection. However, cross‐reactivity‐based sensor arrays often lack accuracy, despite comprehensive data analysis; while traditional high‐affinity‐based sensors based on antibodies/aptamers frequently suffer fro...
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| Format: | Article |
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Wiley
2025-07-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202502452 |
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| author | Tongtong Ma Qiao Huang Lei Yuan Shugang Yan Yalin Mo Yibin Ying Yingchun Fu Jinming Pan |
| author_facet | Tongtong Ma Qiao Huang Lei Yuan Shugang Yan Yalin Mo Yibin Ying Yingchun Fu Jinming Pan |
| author_sort | Tongtong Ma |
| collection | DOAJ |
| description | Abstract Sensor array offers significant potential for rapid, high‐throughput antibiotic detection. However, cross‐reactivity‐based sensor arrays often lack accuracy, despite comprehensive data analysis; while traditional high‐affinity‐based sensors based on antibodies/aptamers frequently suffer from complicated design and poor robustness. Here, a filterable paper‐based fluorescent metal–organic frameworks (MOFs) sensor array is developed for one‐to‐one recognition and quantification of multiple antibiotics. Three representative MOFs are designed to exceptional affinity and specificity for the target antibiotic. A filtration‐assisted detection enhances sensitivity, achieving parts‐per‐billion (ppb)‐level detection in mixed solutions. The proposed approach integrates recognition and signal generation, streamlined 10‐min process. The robustness of the MOFs also enables direct detection in raw samples containing organic solvents, which is not achievable by conventional methods. Notably, the sensor array can be easily incorporated into a smartphone‐based portable device, coupled with a user‐friendly image analysis applet for one‐step extraction and quantitative detection in chicken samples. Leveraging MOFs’ versatility, this method can be extended to simultaneously detect a broad range of antibiotics, offering the potential for universal, high‐throughput accurate detection of various chemical targets. |
| format | Article |
| id | doaj-art-ce96a8cefaa5469fa42922a16cff9282 |
| institution | DOAJ |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-ce96a8cefaa5469fa42922a16cff92822025-08-20T03:12:02ZengWileyAdvanced Science2198-38442025-07-011227n/an/a10.1002/advs.202502452Tailored Fluorescent Metal–Organic Frameworks Hybrid Membrane Sensor Arrays: Simultaneous and Selective Quantification of Multiple AntibioticsTongtong Ma0Qiao Huang1Lei Yuan2Shugang Yan3Yalin Mo4Yibin Ying5Yingchun Fu6Jinming Pan7College of Biosystems Engineering and Food Science Zhejiang Key Laboratory of Intelligent Sensing and Robotics for Agriculture Zhejiang University Hangzhou 310058 ChinaCollege of Biosystems Engineering and Food Science Zhejiang Key Laboratory of Intelligent Sensing and Robotics for Agriculture Zhejiang University Hangzhou 310058 ChinaCollege of Biosystems Engineering and Food Science Zhejiang Key Laboratory of Intelligent Sensing and Robotics for Agriculture Zhejiang University Hangzhou 310058 ChinaCollege of Biosystems Engineering and Food Science Zhejiang Key Laboratory of Intelligent Sensing and Robotics for Agriculture Zhejiang University Hangzhou 310058 ChinaCollege of Biosystems Engineering and Food Science Zhejiang Key Laboratory of Intelligent Sensing and Robotics for Agriculture Zhejiang University Hangzhou 310058 ChinaCollege of Biosystems Engineering and Food Science Zhejiang Key Laboratory of Intelligent Sensing and Robotics for Agriculture Zhejiang University Hangzhou 310058 ChinaCollege of Biosystems Engineering and Food Science Zhejiang Key Laboratory of Intelligent Sensing and Robotics for Agriculture Zhejiang University Hangzhou 310058 ChinaCollege of Biosystems Engineering and Food Science Zhejiang Key Laboratory of Intelligent Sensing and Robotics for Agriculture Zhejiang University Hangzhou 310058 ChinaAbstract Sensor array offers significant potential for rapid, high‐throughput antibiotic detection. However, cross‐reactivity‐based sensor arrays often lack accuracy, despite comprehensive data analysis; while traditional high‐affinity‐based sensors based on antibodies/aptamers frequently suffer from complicated design and poor robustness. Here, a filterable paper‐based fluorescent metal–organic frameworks (MOFs) sensor array is developed for one‐to‐one recognition and quantification of multiple antibiotics. Three representative MOFs are designed to exceptional affinity and specificity for the target antibiotic. A filtration‐assisted detection enhances sensitivity, achieving parts‐per‐billion (ppb)‐level detection in mixed solutions. The proposed approach integrates recognition and signal generation, streamlined 10‐min process. The robustness of the MOFs also enables direct detection in raw samples containing organic solvents, which is not achievable by conventional methods. Notably, the sensor array can be easily incorporated into a smartphone‐based portable device, coupled with a user‐friendly image analysis applet for one‐step extraction and quantitative detection in chicken samples. Leveraging MOFs’ versatility, this method can be extended to simultaneously detect a broad range of antibiotics, offering the potential for universal, high‐throughput accurate detection of various chemical targets.https://doi.org/10.1002/advs.202502452antibioticshybrid membranemetal–organic frameworksensor arraysimultaneous detection |
| spellingShingle | Tongtong Ma Qiao Huang Lei Yuan Shugang Yan Yalin Mo Yibin Ying Yingchun Fu Jinming Pan Tailored Fluorescent Metal–Organic Frameworks Hybrid Membrane Sensor Arrays: Simultaneous and Selective Quantification of Multiple Antibiotics Advanced Science antibiotics hybrid membrane metal–organic framework sensor array simultaneous detection |
| title | Tailored Fluorescent Metal–Organic Frameworks Hybrid Membrane Sensor Arrays: Simultaneous and Selective Quantification of Multiple Antibiotics |
| title_full | Tailored Fluorescent Metal–Organic Frameworks Hybrid Membrane Sensor Arrays: Simultaneous and Selective Quantification of Multiple Antibiotics |
| title_fullStr | Tailored Fluorescent Metal–Organic Frameworks Hybrid Membrane Sensor Arrays: Simultaneous and Selective Quantification of Multiple Antibiotics |
| title_full_unstemmed | Tailored Fluorescent Metal–Organic Frameworks Hybrid Membrane Sensor Arrays: Simultaneous and Selective Quantification of Multiple Antibiotics |
| title_short | Tailored Fluorescent Metal–Organic Frameworks Hybrid Membrane Sensor Arrays: Simultaneous and Selective Quantification of Multiple Antibiotics |
| title_sort | tailored fluorescent metal organic frameworks hybrid membrane sensor arrays simultaneous and selective quantification of multiple antibiotics |
| topic | antibiotics hybrid membrane metal–organic framework sensor array simultaneous detection |
| url | https://doi.org/10.1002/advs.202502452 |
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