Epicardial Fat: Physiological, Pathological, and Therapeutic Implications
Epicardial fat is closely related to blood supply vessels, both anatomically and functionally, which is why any change in this adipose tissue’s behavior is considered a potential risk factor for cardiovascular disease development. When proinflammatory adipokines are released from the epicardial fat,...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/1291537 |
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| author | Juan Salazar Eliana Luzardo José Carlos Mejías Joselyn Rojas Antonio Ferreira José Ramón Rivas-Ríos Valmore Bermúdez |
| author_facet | Juan Salazar Eliana Luzardo José Carlos Mejías Joselyn Rojas Antonio Ferreira José Ramón Rivas-Ríos Valmore Bermúdez |
| author_sort | Juan Salazar |
| collection | DOAJ |
| description | Epicardial fat is closely related to blood supply vessels, both anatomically and functionally, which is why any change in this adipose tissue’s behavior is considered a potential risk factor for cardiovascular disease development. When proinflammatory adipokines are released from the epicardial fat, this can lead to a decrease in insulin sensitivity, low adiponectin production, and an increased proliferation of vascular smooth muscle cells. These adipokines move from one compartment to another by either transcellular passing or diffusion, thus having the ability to regulate cardiac muscle activity, a phenomenon called vasocrine regulation. The participation of these adipokines generates a state of persistent vasoconstriction, increased stiffness, and weakening of the coronary wall, consequently contributing to the formation of atherosclerotic plaques. Therefore, epicardial adipose tissue thickening should be considered a risk factor in the development of cardiovascular disease, a potential therapeutic target for cardiovascular pathology and a molecular point of contact for “endocrine-cardiology.” |
| format | Article |
| id | doaj-art-ce957e7ce3604fc99b33050b75c5c5d1 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-ce957e7ce3604fc99b33050b75c5c5d12025-02-03T06:01:43ZengWileyCardiology Research and Practice2090-80162090-05972016-01-01201610.1155/2016/12915371291537Epicardial Fat: Physiological, Pathological, and Therapeutic ImplicationsJuan Salazar0Eliana Luzardo1José Carlos Mejías2Joselyn Rojas3Antonio Ferreira4José Ramón Rivas-Ríos5Valmore Bermúdez6Endocrine and Metabolic Diseases Research Center, University of Zulia, Maracaibo 4004, VenezuelaEndocrine and Metabolic Diseases Research Center, University of Zulia, Maracaibo 4004, VenezuelaEndocrine and Metabolic Diseases Research Center, University of Zulia, Maracaibo 4004, VenezuelaEndocrine and Metabolic Diseases Research Center, University of Zulia, Maracaibo 4004, VenezuelaEndocrine and Metabolic Diseases Research Center, University of Zulia, Maracaibo 4004, VenezuelaEndocrine and Metabolic Diseases Research Center, University of Zulia, Maracaibo 4004, VenezuelaEndocrine and Metabolic Diseases Research Center, University of Zulia, Maracaibo 4004, VenezuelaEpicardial fat is closely related to blood supply vessels, both anatomically and functionally, which is why any change in this adipose tissue’s behavior is considered a potential risk factor for cardiovascular disease development. When proinflammatory adipokines are released from the epicardial fat, this can lead to a decrease in insulin sensitivity, low adiponectin production, and an increased proliferation of vascular smooth muscle cells. These adipokines move from one compartment to another by either transcellular passing or diffusion, thus having the ability to regulate cardiac muscle activity, a phenomenon called vasocrine regulation. The participation of these adipokines generates a state of persistent vasoconstriction, increased stiffness, and weakening of the coronary wall, consequently contributing to the formation of atherosclerotic plaques. Therefore, epicardial adipose tissue thickening should be considered a risk factor in the development of cardiovascular disease, a potential therapeutic target for cardiovascular pathology and a molecular point of contact for “endocrine-cardiology.”http://dx.doi.org/10.1155/2016/1291537 |
| spellingShingle | Juan Salazar Eliana Luzardo José Carlos Mejías Joselyn Rojas Antonio Ferreira José Ramón Rivas-Ríos Valmore Bermúdez Epicardial Fat: Physiological, Pathological, and Therapeutic Implications Cardiology Research and Practice |
| title | Epicardial Fat: Physiological, Pathological, and Therapeutic Implications |
| title_full | Epicardial Fat: Physiological, Pathological, and Therapeutic Implications |
| title_fullStr | Epicardial Fat: Physiological, Pathological, and Therapeutic Implications |
| title_full_unstemmed | Epicardial Fat: Physiological, Pathological, and Therapeutic Implications |
| title_short | Epicardial Fat: Physiological, Pathological, and Therapeutic Implications |
| title_sort | epicardial fat physiological pathological and therapeutic implications |
| url | http://dx.doi.org/10.1155/2016/1291537 |
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