Clinical and Pathological Features of Childhood-Onset Nemaline Myopathy: A Report of Four Cases
We examined whether immunological abnormalities can be found in the specimens of four childhood-onset nemaline myopathy (NM) patients without autoimmune diseases. Pathological examination revealed that nemaline rods were found in all specimens. The immunohistochemical results showed that CD4 positiv...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/203602 |
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| _version_ | 1832562769798365184 |
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| author | Chao Jiang Jianping Wang Haidong Lu |
| author_facet | Chao Jiang Jianping Wang Haidong Lu |
| author_sort | Chao Jiang |
| collection | DOAJ |
| description | We examined whether immunological abnormalities can be found in the specimens of four childhood-onset nemaline myopathy (NM) patients without autoimmune diseases. Pathological examination revealed that nemaline rods were found in all specimens. The immunohistochemical results showed that CD4 positive cells and some other cells were gathered among the necrotic muscle fibers. We conclude that immunological abnormalities are present in the specimens of certain childhood-onset NM patients without autoimmune diseases. Further evaluation of the immunological changes is warranted in childhood-onset NM patients. |
| format | Article |
| id | doaj-art-ce937820d21e4264a312c3d623d76814 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-ce937820d21e4264a312c3d623d768142025-02-03T01:21:56ZengWileyCase Reports in Medicine1687-96271687-96352012-01-01201210.1155/2012/203602203602Clinical and Pathological Features of Childhood-Onset Nemaline Myopathy: A Report of Four CasesChao Jiang0Jianping Wang1Haidong Lu2Department of Neurology, The Fifth Affiliated Hospital of Zhengzhou University, Henan, Zhengzhou 450052, ChinaDepartment of Neurology, The Fifth Affiliated Hospital of Zhengzhou University, Henan, Zhengzhou 450052, ChinaDepartment of Neurology, The People's Hospital of Jiaozuo City, Henan, Jiaozou 450052, ChinaWe examined whether immunological abnormalities can be found in the specimens of four childhood-onset nemaline myopathy (NM) patients without autoimmune diseases. Pathological examination revealed that nemaline rods were found in all specimens. The immunohistochemical results showed that CD4 positive cells and some other cells were gathered among the necrotic muscle fibers. We conclude that immunological abnormalities are present in the specimens of certain childhood-onset NM patients without autoimmune diseases. Further evaluation of the immunological changes is warranted in childhood-onset NM patients.http://dx.doi.org/10.1155/2012/203602 |
| spellingShingle | Chao Jiang Jianping Wang Haidong Lu Clinical and Pathological Features of Childhood-Onset Nemaline Myopathy: A Report of Four Cases Case Reports in Medicine |
| title | Clinical and Pathological Features of Childhood-Onset Nemaline Myopathy: A Report of Four Cases |
| title_full | Clinical and Pathological Features of Childhood-Onset Nemaline Myopathy: A Report of Four Cases |
| title_fullStr | Clinical and Pathological Features of Childhood-Onset Nemaline Myopathy: A Report of Four Cases |
| title_full_unstemmed | Clinical and Pathological Features of Childhood-Onset Nemaline Myopathy: A Report of Four Cases |
| title_short | Clinical and Pathological Features of Childhood-Onset Nemaline Myopathy: A Report of Four Cases |
| title_sort | clinical and pathological features of childhood onset nemaline myopathy a report of four cases |
| url | http://dx.doi.org/10.1155/2012/203602 |
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