Dengue haemorrhagic fever: a job done via exosomes?
Dengue fever is one of those unique diseases where host immune responses largely determine the pathogenesis and its severity. Earlier studies have established the fact that dengue virus (DENV) infection causes haemorrhagic fever and shock syndrome, but it is not directly responsible for exhibiting t...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2019.1685913 |
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| author | Ritu Mishra Sneh Lata Amjad Ali Akhil C. Banerjea |
| author_facet | Ritu Mishra Sneh Lata Amjad Ali Akhil C. Banerjea |
| author_sort | Ritu Mishra |
| collection | DOAJ |
| description | Dengue fever is one of those unique diseases where host immune responses largely determine the pathogenesis and its severity. Earlier studies have established the fact that dengue virus (DENV) infection causes haemorrhagic fever and shock syndrome, but it is not directly responsible for exhibiting these clinical symptoms. It is noteworthy that clinically, vascular leakage syndrome does not develop for several days after infection despite a robust innate immune response that elicits the production of proinflammatory and proangiogenic cytokines. The onset of hyperpermeability in severe cases of dengue disease takes place around the time of defervescence and after clearance of viraemia. Extracellular vesicles are known to carry biological information (mRNA, miRNA, transcription factors) from their cells of origin and have emerged as a significant vehicle for horizontal transfer of stress signals. In dengue virus infection, the relevance of exosomes can be instrumental since the majority of the immune responses in severe dengue involve heavy secretion and circulation of pro-inflammatory cytokines and chemokines. Here, we present an updated review which will address the unique and puzzling features of hyperpermeability associated with DENV infection with a special focus on the role of secreted extracellular vesicles. |
| format | Article |
| id | doaj-art-ce8efbcd24bd4abab09bdf273f5ad4ea |
| institution | DOAJ |
| issn | 2222-1751 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-ce8efbcd24bd4abab09bdf273f5ad4ea2025-08-20T03:17:54ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512019-01-01811626163510.1080/22221751.2019.1685913Dengue haemorrhagic fever: a job done via exosomes?Ritu Mishra0Sneh Lata1Amjad Ali2Akhil C. Banerjea3Laboratory of Virology, National Institute of Immunology, New Delhi, IndiaLaboratory of Virology, National Institute of Immunology, New Delhi, IndiaJamia Millia Islamia, Okhla, New Delhi, IndiaLaboratory of Virology, National Institute of Immunology, New Delhi, IndiaDengue fever is one of those unique diseases where host immune responses largely determine the pathogenesis and its severity. Earlier studies have established the fact that dengue virus (DENV) infection causes haemorrhagic fever and shock syndrome, but it is not directly responsible for exhibiting these clinical symptoms. It is noteworthy that clinically, vascular leakage syndrome does not develop for several days after infection despite a robust innate immune response that elicits the production of proinflammatory and proangiogenic cytokines. The onset of hyperpermeability in severe cases of dengue disease takes place around the time of defervescence and after clearance of viraemia. Extracellular vesicles are known to carry biological information (mRNA, miRNA, transcription factors) from their cells of origin and have emerged as a significant vehicle for horizontal transfer of stress signals. In dengue virus infection, the relevance of exosomes can be instrumental since the majority of the immune responses in severe dengue involve heavy secretion and circulation of pro-inflammatory cytokines and chemokines. Here, we present an updated review which will address the unique and puzzling features of hyperpermeability associated with DENV infection with a special focus on the role of secreted extracellular vesicles.https://www.tandfonline.com/doi/10.1080/22221751.2019.1685913Dengue virusdengue haemorrhagic fevermicroRNAexosomeshyperpermeability |
| spellingShingle | Ritu Mishra Sneh Lata Amjad Ali Akhil C. Banerjea Dengue haemorrhagic fever: a job done via exosomes? Emerging Microbes and Infections Dengue virus dengue haemorrhagic fever microRNA exosomes hyperpermeability |
| title | Dengue haemorrhagic fever: a job done via exosomes? |
| title_full | Dengue haemorrhagic fever: a job done via exosomes? |
| title_fullStr | Dengue haemorrhagic fever: a job done via exosomes? |
| title_full_unstemmed | Dengue haemorrhagic fever: a job done via exosomes? |
| title_short | Dengue haemorrhagic fever: a job done via exosomes? |
| title_sort | dengue haemorrhagic fever a job done via exosomes |
| topic | Dengue virus dengue haemorrhagic fever microRNA exosomes hyperpermeability |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2019.1685913 |
| work_keys_str_mv | AT ritumishra denguehaemorrhagicfeverajobdoneviaexosomes AT snehlata denguehaemorrhagicfeverajobdoneviaexosomes AT amjadali denguehaemorrhagicfeverajobdoneviaexosomes AT akhilcbanerjea denguehaemorrhagicfeverajobdoneviaexosomes |