Copper Methacrylate Complexes with Benzimidazole Derivatives: Structural Characterization and Antimicrobial Assays
In order to design antimicrobial species, a series of methacrylate (Macr) complexes, [Cu(HBzIm)<sub>2</sub>(Macr)<sub>2</sub>] (<b>1</b>), [Cu<sub>2</sub>(HBzIm)<sub>2</sub>(Macr)<sub>4</sub>] (<b>2</b>), [Cu(2-MeBzI...
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2025-04-01
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| author | Andra-Georgeta Andrei Rodica Olar Cătălin Maxim Gina Vasile Scăețeanu Ioana-Cristina Marinas Madalina-Diana Gaboreanu Mihaela Badea |
| author_facet | Andra-Georgeta Andrei Rodica Olar Cătălin Maxim Gina Vasile Scăețeanu Ioana-Cristina Marinas Madalina-Diana Gaboreanu Mihaela Badea |
| author_sort | Andra-Georgeta Andrei |
| collection | DOAJ |
| description | In order to design antimicrobial species, a series of methacrylate (Macr) complexes, [Cu(HBzIm)<sub>2</sub>(Macr)<sub>2</sub>] (<b>1</b>), [Cu<sub>2</sub>(HBzIm)<sub>2</sub>(Macr)<sub>4</sub>] (<b>2</b>), [Cu(2-MeBzIm)<sub>2</sub>(Macr)<sub>2</sub>] (<b>3</b>), [Cu<sub>2</sub>(2-MeBzIm)<sub>2</sub>(Macr)<sub>4</sub>] (<b>4</b>), and [Cu(5,6-Me<sub>2</sub>BzIm)<sub>2</sub>(Macr)<sub>2</sub>] (<b>5</b>) (HBzIm = benzimidazole, 2-MeBzIm = 2-methylbenzimidazole, and 5,6-Me<sub>2</sub>BzIm = 5,6-dimethylbenzimidazole) were synthesized and characterized by several spectral techniques, as well as by single crystal X-ray diffraction. The mononuclear species exhibit a distorted octahedral stereochemistry, while the binuclear types, with a paddle-wheel structure, adopt a square pyramidal surrounding. The methacrylate acts either as a chelate or a bridge, while all benzimidazole derivatives are coordinated as unidentate. The supramolecular networks are developed by both intermolecular π–π stacking interactions and hydrogen bonds. The antimicrobial assays provided both complexes the ability to inhibit planktonic strain proliferation, as well as to adhere on inert substratum. All complexes exhibit a moderate antimicrobial activity, both in regards to standard and clinical isolate strains, the most active being compound <b>5</b> against <i>Candida albicans</i>, with a minimum inhibitory concentration (MIC) of 0.156 mg/mL. It is worth mentioning that complex <b>1</b> inhibited the microbial adhesion of the clinical <i>Escherichia coli</i> strain and complex <b>2</b> constrained that of the clinical <i>C. albicans</i> strain. |
| format | Article |
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| institution | DOAJ |
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| publishDate | 2025-04-01 |
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| spelling | doaj-art-ce8c7bf3c36849698c5d3593682d489c2025-08-20T03:13:45ZengMDPI AGInorganics2304-67402025-04-0113410910.3390/inorganics13040109Copper Methacrylate Complexes with Benzimidazole Derivatives: Structural Characterization and Antimicrobial AssaysAndra-Georgeta Andrei0Rodica Olar1Cătălin Maxim2Gina Vasile Scăețeanu3Ioana-Cristina Marinas4Madalina-Diana Gaboreanu5Mihaela Badea6Department of Inorganic and Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663 Bucharest, RomaniaDepartment of Inorganic and Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663 Bucharest, RomaniaDepartment of Inorganic and Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663 Bucharest, RomaniaDepartment of Soil Sciences, Faculty of Agriculture, University of Agronomic Sciences and Veterinary Medicine, 59 Mărăști Str., 011464 Bucharest, RomaniaThe Research Institute of the University of Bucharest (ICUB), University of Bucharest, 050095 Bucharest, RomaniaThe Research Institute of the University of Bucharest (ICUB), University of Bucharest, 050095 Bucharest, RomaniaDepartment of Inorganic and Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663 Bucharest, RomaniaIn order to design antimicrobial species, a series of methacrylate (Macr) complexes, [Cu(HBzIm)<sub>2</sub>(Macr)<sub>2</sub>] (<b>1</b>), [Cu<sub>2</sub>(HBzIm)<sub>2</sub>(Macr)<sub>4</sub>] (<b>2</b>), [Cu(2-MeBzIm)<sub>2</sub>(Macr)<sub>2</sub>] (<b>3</b>), [Cu<sub>2</sub>(2-MeBzIm)<sub>2</sub>(Macr)<sub>4</sub>] (<b>4</b>), and [Cu(5,6-Me<sub>2</sub>BzIm)<sub>2</sub>(Macr)<sub>2</sub>] (<b>5</b>) (HBzIm = benzimidazole, 2-MeBzIm = 2-methylbenzimidazole, and 5,6-Me<sub>2</sub>BzIm = 5,6-dimethylbenzimidazole) were synthesized and characterized by several spectral techniques, as well as by single crystal X-ray diffraction. The mononuclear species exhibit a distorted octahedral stereochemistry, while the binuclear types, with a paddle-wheel structure, adopt a square pyramidal surrounding. The methacrylate acts either as a chelate or a bridge, while all benzimidazole derivatives are coordinated as unidentate. The supramolecular networks are developed by both intermolecular π–π stacking interactions and hydrogen bonds. The antimicrobial assays provided both complexes the ability to inhibit planktonic strain proliferation, as well as to adhere on inert substratum. All complexes exhibit a moderate antimicrobial activity, both in regards to standard and clinical isolate strains, the most active being compound <b>5</b> against <i>Candida albicans</i>, with a minimum inhibitory concentration (MIC) of 0.156 mg/mL. It is worth mentioning that complex <b>1</b> inhibited the microbial adhesion of the clinical <i>Escherichia coli</i> strain and complex <b>2</b> constrained that of the clinical <i>C. albicans</i> strain.https://www.mdpi.com/2304-6740/13/4/109Cu(II) complexbenzimidazolemethacrylatecrystal structuremicrobial adhesion |
| spellingShingle | Andra-Georgeta Andrei Rodica Olar Cătălin Maxim Gina Vasile Scăețeanu Ioana-Cristina Marinas Madalina-Diana Gaboreanu Mihaela Badea Copper Methacrylate Complexes with Benzimidazole Derivatives: Structural Characterization and Antimicrobial Assays Inorganics Cu(II) complex benzimidazole methacrylate crystal structure microbial adhesion |
| title | Copper Methacrylate Complexes with Benzimidazole Derivatives: Structural Characterization and Antimicrobial Assays |
| title_full | Copper Methacrylate Complexes with Benzimidazole Derivatives: Structural Characterization and Antimicrobial Assays |
| title_fullStr | Copper Methacrylate Complexes with Benzimidazole Derivatives: Structural Characterization and Antimicrobial Assays |
| title_full_unstemmed | Copper Methacrylate Complexes with Benzimidazole Derivatives: Structural Characterization and Antimicrobial Assays |
| title_short | Copper Methacrylate Complexes with Benzimidazole Derivatives: Structural Characterization and Antimicrobial Assays |
| title_sort | copper methacrylate complexes with benzimidazole derivatives structural characterization and antimicrobial assays |
| topic | Cu(II) complex benzimidazole methacrylate crystal structure microbial adhesion |
| url | https://www.mdpi.com/2304-6740/13/4/109 |
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