Microwave Extraction of Gallic Acid Equivalent of Total Flavonoids from Nigella sativa
Unfortunately, cancer is the most widespread disease in worldwide. Colorectal cancer is declared as the third most common cancer type. The usage of controlled-drug-releasing capsules for treating the cancer diseases has becoming more and more popular in the whole world. In the production of drug raw...
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| Format: | Article |
| Language: | English |
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izzet kara
2017-12-01
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| Series: | International Journal of Secondary Metabolite |
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| Online Access: | https://dergipark.org.tr/tr/pub/ijsm/issue/32131/363838?publisher=ijate |
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| _version_ | 1850175281107566592 |
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| author | Burcu Özturk Sibel Yiğitarslan |
| author_facet | Burcu Özturk Sibel Yiğitarslan |
| author_sort | Burcu Özturk |
| collection | DOAJ |
| description | Unfortunately, cancer is the most widespread disease in
worldwide. Colorectal cancer is declared as the third most common cancer type. The
usage of controlled-drug-releasing capsules for treating the cancer diseases has
becoming more and more popular in the whole world. In the production of drug raw
material, the first operation is an extraction of the phytochemicals from the herbal
plant. The yield of the extraction operation is an important step for the economical
and efficient production of such capsules. Thus the aim of this study was to optimize
the microwave extraction of total flavonoids from Nigella sativa with methanol by using Response Surface Methodology based
on Box-Behnken design. Microwave extraction experiments had been carried out with
the parameters of microwave power, solid/liquid ratio and the and the application
time. The optimum values were determined as 0.62 kW, 1/(47) g/mL, and 10.84 second,
respectively. According to the quadratic surface of the extraction yield depending
on those parameters, 309.60 mg/100g of gallic acid equivalent of total flavonoids
can be obtained at the optimum conditions. As a result of the statistical analysis,
this function was found as capable of expressing the effect of the parameters on
the amount of total flavonoid production in industry. Nowadays, drying of the extracts
and loading of the aqueous solutions of them into the prebiotic-coated probiotic
capsules have been under consideration. |
| format | Article |
| id | doaj-art-ce89ede21e2e4ef8a94f83b8dafc49c9 |
| institution | OA Journals |
| issn | 2148-6905 |
| language | English |
| publishDate | 2017-12-01 |
| publisher | izzet kara |
| record_format | Article |
| series | International Journal of Secondary Metabolite |
| spelling | doaj-art-ce89ede21e2e4ef8a94f83b8dafc49c92025-08-20T02:19:30Zengizzet karaInternational Journal of Secondary Metabolite2148-69052017-12-0143, Special Issue 111712410.21448/ijsm.363838618Microwave Extraction of Gallic Acid Equivalent of Total Flavonoids from Nigella sativaBurcu ÖzturkSibel YiğitarslanUnfortunately, cancer is the most widespread disease in worldwide. Colorectal cancer is declared as the third most common cancer type. The usage of controlled-drug-releasing capsules for treating the cancer diseases has becoming more and more popular in the whole world. In the production of drug raw material, the first operation is an extraction of the phytochemicals from the herbal plant. The yield of the extraction operation is an important step for the economical and efficient production of such capsules. Thus the aim of this study was to optimize the microwave extraction of total flavonoids from Nigella sativa with methanol by using Response Surface Methodology based on Box-Behnken design. Microwave extraction experiments had been carried out with the parameters of microwave power, solid/liquid ratio and the and the application time. The optimum values were determined as 0.62 kW, 1/(47) g/mL, and 10.84 second, respectively. According to the quadratic surface of the extraction yield depending on those parameters, 309.60 mg/100g of gallic acid equivalent of total flavonoids can be obtained at the optimum conditions. As a result of the statistical analysis, this function was found as capable of expressing the effect of the parameters on the amount of total flavonoid production in industry. Nowadays, drying of the extracts and loading of the aqueous solutions of them into the prebiotic-coated probiotic capsules have been under consideration.https://dergipark.org.tr/tr/pub/ijsm/issue/32131/363838?publisher=ijatenigella sativaextractionflavonoidresponse surface methodology |
| spellingShingle | Burcu Özturk Sibel Yiğitarslan Microwave Extraction of Gallic Acid Equivalent of Total Flavonoids from Nigella sativa International Journal of Secondary Metabolite nigella sativa extraction flavonoid response surface methodology |
| title | Microwave Extraction of Gallic Acid Equivalent of Total Flavonoids from Nigella sativa |
| title_full | Microwave Extraction of Gallic Acid Equivalent of Total Flavonoids from Nigella sativa |
| title_fullStr | Microwave Extraction of Gallic Acid Equivalent of Total Flavonoids from Nigella sativa |
| title_full_unstemmed | Microwave Extraction of Gallic Acid Equivalent of Total Flavonoids from Nigella sativa |
| title_short | Microwave Extraction of Gallic Acid Equivalent of Total Flavonoids from Nigella sativa |
| title_sort | microwave extraction of gallic acid equivalent of total flavonoids from nigella sativa |
| topic | nigella sativa extraction flavonoid response surface methodology |
| url | https://dergipark.org.tr/tr/pub/ijsm/issue/32131/363838?publisher=ijate |
| work_keys_str_mv | AT burcuozturk microwaveextractionofgallicacidequivalentoftotalflavonoidsfromnigellasativa AT sibelyigitarslan microwaveextractionofgallicacidequivalentoftotalflavonoidsfromnigellasativa |