A pyromellitic acid-based Deep Eutectic Solvent as a new and powerful catalyst for the synthesis of tetrahydropyridines
Based on the results obtained from the eutectic points phase diagram, a novel deep eutectic solvent (ChCl/PYRO-DES) was prepared with two to one molar ratio of choline chloride (ChCl) to pyromellitic acid (1,2,4,5-benzenetetra-carboxylic acid, PYRO) at 140 °C in a cheap, simple, and non-toxic method...
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Elsevier
2025-01-01
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| Series: | Applied Catalysis O: Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950648424001093 |
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| author | Hadis Goudarzi Davood Habibi Arezo Monem Maryam Mahmoudiani-Glian Amin Benrashid Zahra Alshablawi |
| author_facet | Hadis Goudarzi Davood Habibi Arezo Monem Maryam Mahmoudiani-Glian Amin Benrashid Zahra Alshablawi |
| author_sort | Hadis Goudarzi |
| collection | DOAJ |
| description | Based on the results obtained from the eutectic points phase diagram, a novel deep eutectic solvent (ChCl/PYRO-DES) was prepared with two to one molar ratio of choline chloride (ChCl) to pyromellitic acid (1,2,4,5-benzenetetra-carboxylic acid, PYRO) at 140 °C in a cheap, simple, and non-toxic method and characterized by FT-IR, densitometer, TGA-DTA and 1H NMR techniques. Then, it was used as a capable and new catalyst for the synthesis of alkyl 1,2,6-trisubstituted-4-[(hetero)-arylamino]-1,2,5,6-tetrahydropyridine-3-carboxylates 3(a-j) from the mixture of β-keto-ester, anilines, and aromatic aldehyde at 80 °C in solvent-free conditions, short reaction times, high yields, and easy recycling and separation of the DES catalyst. |
| format | Article |
| id | doaj-art-ce8799b3d87b4baca8ad68ebe50a7d86 |
| institution | OA Journals |
| issn | 2950-6484 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Applied Catalysis O: Open |
| spelling | doaj-art-ce8799b3d87b4baca8ad68ebe50a7d862025-08-20T02:34:38ZengElsevierApplied Catalysis O: Open2950-64842025-01-0119820702310.1016/j.apcato.2024.207023A pyromellitic acid-based Deep Eutectic Solvent as a new and powerful catalyst for the synthesis of tetrahydropyridinesHadis Goudarzi0Davood Habibi1Arezo Monem2Maryam Mahmoudiani-Glian3Amin Benrashid4Zahra Alshablawi5Department of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina University, Hamedan, IranCorresponding author.; Department of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina University, Hamedan, IranDepartment of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina University, Hamedan, IranDepartment of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina University, Hamedan, IranDepartment of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina University, Hamedan, IranDepartment of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina University, Hamedan, IranBased on the results obtained from the eutectic points phase diagram, a novel deep eutectic solvent (ChCl/PYRO-DES) was prepared with two to one molar ratio of choline chloride (ChCl) to pyromellitic acid (1,2,4,5-benzenetetra-carboxylic acid, PYRO) at 140 °C in a cheap, simple, and non-toxic method and characterized by FT-IR, densitometer, TGA-DTA and 1H NMR techniques. Then, it was used as a capable and new catalyst for the synthesis of alkyl 1,2,6-trisubstituted-4-[(hetero)-arylamino]-1,2,5,6-tetrahydropyridine-3-carboxylates 3(a-j) from the mixture of β-keto-ester, anilines, and aromatic aldehyde at 80 °C in solvent-free conditions, short reaction times, high yields, and easy recycling and separation of the DES catalyst.http://www.sciencedirect.com/science/article/pii/S2950648424001093Choline chloridePyromellitic acidDeep eutectic solventTetrahydropyridinesCatalysis |
| spellingShingle | Hadis Goudarzi Davood Habibi Arezo Monem Maryam Mahmoudiani-Glian Amin Benrashid Zahra Alshablawi A pyromellitic acid-based Deep Eutectic Solvent as a new and powerful catalyst for the synthesis of tetrahydropyridines Applied Catalysis O: Open Choline chloride Pyromellitic acid Deep eutectic solvent Tetrahydropyridines Catalysis |
| title | A pyromellitic acid-based Deep Eutectic Solvent as a new and powerful catalyst for the synthesis of tetrahydropyridines |
| title_full | A pyromellitic acid-based Deep Eutectic Solvent as a new and powerful catalyst for the synthesis of tetrahydropyridines |
| title_fullStr | A pyromellitic acid-based Deep Eutectic Solvent as a new and powerful catalyst for the synthesis of tetrahydropyridines |
| title_full_unstemmed | A pyromellitic acid-based Deep Eutectic Solvent as a new and powerful catalyst for the synthesis of tetrahydropyridines |
| title_short | A pyromellitic acid-based Deep Eutectic Solvent as a new and powerful catalyst for the synthesis of tetrahydropyridines |
| title_sort | pyromellitic acid based deep eutectic solvent as a new and powerful catalyst for the synthesis of tetrahydropyridines |
| topic | Choline chloride Pyromellitic acid Deep eutectic solvent Tetrahydropyridines Catalysis |
| url | http://www.sciencedirect.com/science/article/pii/S2950648424001093 |
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