SLM Ti12Mo6Zr2Fe-xCu implants: in-situ precipitating nanoscale Ti-Cu phase induced bio-functional properties
Although a novel full β-Ti alloy (Ti12Mo6Zr2Fe) possessing the excellent mechanical properties could be developed using selective laser melting (SLM) technology, nevertheless, inherent bio-inertness still limits its clinical application. To modify its composition induce bioactivity, a series of SLM...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
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| Series: | Virtual and Physical Prototyping |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/17452759.2025.2525989 |
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| Summary: | Although a novel full β-Ti alloy (Ti12Mo6Zr2Fe) possessing the excellent mechanical properties could be developed using selective laser melting (SLM) technology, nevertheless, inherent bio-inertness still limits its clinical application. To modify its composition induce bioactivity, a series of SLM Ti-12Mo-6Zr-2Fe-xwt.%Cu (SLM TMZF-xCu) alloys were developed. The β-Ti phase along with a few ω-Ti, α"-Ti and Ti2Cu phases constituted the SLM TMZF-xCu microstructures especially in high Cu doped alloys. Within the SLM TMZF-xCu alloys,the SLM TMZF-4Cu alloy with an appropriate corrosion resistance boosted the Cu2+ releasing and wettability, which effectively supported the adhesion, proliferation, and migration of MC3T3-E1 cells. The SLM TMZF-4Cu alloy also exhibited robust antibacterial properties against S. aureus. Furthermore, through its capacity to promote macrophage M2 polarisation, SLM TMZF-4Cu outperformed SLM Ti in promoting osteogenesis, osseointegration, and angiogenesis in the rat knee arthroplasty model. Overall, the SLM TMZF-4Cu alloy with appropriate in-situ nanoscale Ti-Cu precipitates could be thought as a novel pathway to integrate the antibacterial, osteogenic, angiogenic, and biocompatible properties, promoting it as an ideal candidate for bio-functional orthopedic implants. |
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| ISSN: | 1745-2759 1745-2767 |