Potentiation of immune checkpoint blockade with an ITPP radiosensitizer studied with oxygen saturation measurements from photoacoustic imaging

Potentiation of immune checkpoint blockade with an ITPP radiosensitizer studied with oxygen saturation measurements from photoacoustic imaging

Abstract Hypoxia in the tumor microenvironment hinders antitumor immunity. Increasing tumor oxygenation may promote T cell infiltration and tumor control by immune checkpoint blockade (ICB). We found that a radiosensitizer, myo-inositol trispyrophosphate (ITPP), caused oxygen unloading from hemoglob...

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Bibliographic Details
Main Authors: Renee L. Tran, Xiaofei Liang, Jorge de la Cerda, F. William Schuler, Mark D. Pagel
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Tumor hypoxia
ITPP
Immune checkpoint blockade
Photoacoustic imaging
Online Access:https://doi.org/10.1038/s41598-025-05930-0
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