Establishing a Porcine Model of Small for Size Syndrome following Liver Resection
Background. Small for size syndrome (SFSS) is responsible for a high proportion of mortalities and morbidities following extended liver resection. Aim. The aim of this study was to establish a porcine model of SFSS. Methods. Twenty-four Landrace pigs underwent liver resection with a remnant liver vo...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2017/5127178 |
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| author | Mohammad Golriz Maryam Ashrafi Elias Khajeh Ali Majlesara Christa Flechtenmacher Arianeb Mehrabi |
| author_facet | Mohammad Golriz Maryam Ashrafi Elias Khajeh Ali Majlesara Christa Flechtenmacher Arianeb Mehrabi |
| author_sort | Mohammad Golriz |
| collection | DOAJ |
| description | Background. Small for size syndrome (SFSS) is responsible for a high proportion of mortalities and morbidities following extended liver resection. Aim. The aim of this study was to establish a porcine model of SFSS. Methods. Twenty-four Landrace pigs underwent liver resection with a remnant liver volume of 50% (group A, n=8), 25% (group B, n=8), and 15% (group C, n=8). After resection, the animals were followed up for 8 days and clinical, laboratory, and histopathological outcomes were evaluated. Results. The survival rate was significantly lower in group C compared with the other groups (p<0.001). The international normalized ratio, bilirubin, aspartate transaminase, alanine transaminase, and alkaline phosphatase levels increased shortly after surgery in groups B and C, but no change was observed in group A (p<0.05 for all analyses). The histopathological findings in group A were mainly mild mitoses, in group B severe mitoses and hepatocyte ballooning, moderate congestion, and hemorrhage, along with mild necrosis, and in group C extended tissue damage with severe necrosis, hemorrhage, and congestion. Conclusions. Combination of clinical, laboratory, and histopathological evaluations is needed to confirm the diagnosis of SFSS. 75% liver resection in porcine model results in SFSS. 85% liver resection causes irreversible liver failure. |
| format | Article |
| id | doaj-art-ce80ed011ce24aa98e1d3ba5b1ef96d8 |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-ce80ed011ce24aa98e1d3ba5b1ef96d82025-08-20T03:25:08ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972017-01-01201710.1155/2017/51271785127178Establishing a Porcine Model of Small for Size Syndrome following Liver ResectionMohammad Golriz0Maryam Ashrafi1Elias Khajeh2Ali Majlesara3Christa Flechtenmacher4Arianeb Mehrabi5Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, GermanyDepartment of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, GermanyDepartment of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, GermanyDepartment of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, GermanyDepartment of General Pathology, University of Heidelberg, Heidelberg, GermanyDepartment of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, GermanyBackground. Small for size syndrome (SFSS) is responsible for a high proportion of mortalities and morbidities following extended liver resection. Aim. The aim of this study was to establish a porcine model of SFSS. Methods. Twenty-four Landrace pigs underwent liver resection with a remnant liver volume of 50% (group A, n=8), 25% (group B, n=8), and 15% (group C, n=8). After resection, the animals were followed up for 8 days and clinical, laboratory, and histopathological outcomes were evaluated. Results. The survival rate was significantly lower in group C compared with the other groups (p<0.001). The international normalized ratio, bilirubin, aspartate transaminase, alanine transaminase, and alkaline phosphatase levels increased shortly after surgery in groups B and C, but no change was observed in group A (p<0.05 for all analyses). The histopathological findings in group A were mainly mild mitoses, in group B severe mitoses and hepatocyte ballooning, moderate congestion, and hemorrhage, along with mild necrosis, and in group C extended tissue damage with severe necrosis, hemorrhage, and congestion. Conclusions. Combination of clinical, laboratory, and histopathological evaluations is needed to confirm the diagnosis of SFSS. 75% liver resection in porcine model results in SFSS. 85% liver resection causes irreversible liver failure.http://dx.doi.org/10.1155/2017/5127178 |
| spellingShingle | Mohammad Golriz Maryam Ashrafi Elias Khajeh Ali Majlesara Christa Flechtenmacher Arianeb Mehrabi Establishing a Porcine Model of Small for Size Syndrome following Liver Resection Canadian Journal of Gastroenterology and Hepatology |
| title | Establishing a Porcine Model of Small for Size Syndrome following Liver Resection |
| title_full | Establishing a Porcine Model of Small for Size Syndrome following Liver Resection |
| title_fullStr | Establishing a Porcine Model of Small for Size Syndrome following Liver Resection |
| title_full_unstemmed | Establishing a Porcine Model of Small for Size Syndrome following Liver Resection |
| title_short | Establishing a Porcine Model of Small for Size Syndrome following Liver Resection |
| title_sort | establishing a porcine model of small for size syndrome following liver resection |
| url | http://dx.doi.org/10.1155/2017/5127178 |
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