Co-administration of Hibiscus sabdariffa linn and Daflon-500® mitigates weight loss, hyperglycemia, hematological and oxidative changes in male rats with type-2 diabetes
Background: Diabetes mellitus is a complex metabolic disorder associated with persistent hyperglycemia and metabolic imbalance. Flavonoid compounds possess notable qualities in mitigating diabetes and its complications. Aim: Hibiscus sabdariffa linn and daflon-500® were assessed for their effects on...
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Elsevier
2025-02-01
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| Series: | Phytomedicine Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031324001738 |
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| author | Aishat Omobolanle Olatunji Root Oluwapelumi Alegbe Suleiman Folorunsho Ambali Muftau Shittu Ganiu Jimoh Akorede Abdulfatai Aremu Afisu Basiru Jamila Abdulhamid Atata Kolawole Yusuf Suleiman Charles Amoto Shuaibu |
| author_facet | Aishat Omobolanle Olatunji Root Oluwapelumi Alegbe Suleiman Folorunsho Ambali Muftau Shittu Ganiu Jimoh Akorede Abdulfatai Aremu Afisu Basiru Jamila Abdulhamid Atata Kolawole Yusuf Suleiman Charles Amoto Shuaibu |
| author_sort | Aishat Omobolanle Olatunji |
| collection | DOAJ |
| description | Background: Diabetes mellitus is a complex metabolic disorder associated with persistent hyperglycemia and metabolic imbalance. Flavonoid compounds possess notable qualities in mitigating diabetes and its complications. Aim: Hibiscus sabdariffa linn and daflon-500® were assessed for their effects on body weight, blood glucose/indices, and oxidative changes in type-2 diabetes rats over 28 days. Methods: 35 male rats were randomly divided into seven groups (n = 5). Diabetes mellitus was induced in groups 2–7 via a single intraperitoneal injection of streptozotocin (STZ; 55mg/kg). Group 1(DW) received distilled water (2mL/kg) only. Group 2 (STZ; untreated), group 3 {MET; metformin (Glucophage)}, group 4 {HS; Hibiscus sabdariffa (400mg/kg)}, group 5 {DAF; daflon-500® (1000mg/kg)}, group 6 {DAF+HS; daflon-500® (1000mg/kg) and Hibiscus sabdariffa (400mg/kg)}, group 7 {DAF+MET+HS; daflon-500® (1000mg/kg), metformin (Glucophage), and Hibiscus sabdariffa (400mg/kg)}. Body weight and blood glucose were assessed fortnightly. Blood and hepatic/pancreatic tissues were collected for hematological and antioxidant testing. Results: Groups 2–7 revealed a significant (P < 0.05) decrease in body weight on day 14 compared to the increased growth rate observed on day 28 (Group 7).Blood glucose levels significantly increased on days 1 and 14 in groups 2–7 but declined on day 28 in groups 4–7. Significantly higher packed cell volume, hemoglobin levels, red blood cell counts, lymphocytes, and mean corpuscular hemoglobin were observed in groups 5–7. Platelet counts were higher in Groups 2 and 5. Untreated group 2 exhibited considerably reduced catalase activity, glutathione, and malondialdehyde concentrations compared to the treated groups. Conclusion: Hibiscus sabdariffa linn and Daflon-500® expressed substantial hypoglycemic, antioxidant, and hemato-protective effects. |
| format | Article |
| id | doaj-art-ce7ff268f948460f86233d1ecc8d9e24 |
| institution | Kabale University |
| issn | 2667-0313 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
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| series | Phytomedicine Plus |
| spelling | doaj-art-ce7ff268f948460f86233d1ecc8d9e242025-02-10T04:35:10ZengElsevierPhytomedicine Plus2667-03132025-02-0151100699Co-administration of Hibiscus sabdariffa linn and Daflon-500® mitigates weight loss, hyperglycemia, hematological and oxidative changes in male rats with type-2 diabetesAishat Omobolanle Olatunji0Root Oluwapelumi Alegbe1Suleiman Folorunsho Ambali2Muftau Shittu3Ganiu Jimoh Akorede4Abdulfatai Aremu5Afisu Basiru6Jamila Abdulhamid Atata7Kolawole Yusuf Suleiman8Charles Amoto Shuaibu9University of Ilorin, (Veterinary Pharmacology and Toxicology), Ilorin (Kwara), Nigeria; Corresponding author.University of Ilorin, (Veterinary Pharmacology and Toxicology), Ilorin (Kwara), NigeriaUniversity of Ilorin, (Veterinary Pharmacology and Toxicology), Ilorin (Kwara), NigeriaAhmadu Bello University, (Veterinary Pharmacology and Toxicology), Zaria (Kaduna), NigeriaUniversity of Ilorin, (Veterinary Pharmacology and Toxicology), Ilorin (Kwara), NigeriaUniversity of Ilorin, (Veterinary Pharmacology and Toxicology), Ilorin (Kwara), NigeriaUniversity of Ilorin, (Veterinary Physiology and Biochemistry), Ilorin (Kwara), NigeriaUniversity of Ilorin, (Veterinary Pathology), Ilorin (Kwara), NigeriaUniversity of Ilorin, (Veterinary Physiology and Biochemistry), Ilorin (Kwara), NigeriaUniversity of Ilorin, (Veterinary Pharmacology and Toxicology), Ilorin (Kwara), NigeriaBackground: Diabetes mellitus is a complex metabolic disorder associated with persistent hyperglycemia and metabolic imbalance. Flavonoid compounds possess notable qualities in mitigating diabetes and its complications. Aim: Hibiscus sabdariffa linn and daflon-500® were assessed for their effects on body weight, blood glucose/indices, and oxidative changes in type-2 diabetes rats over 28 days. Methods: 35 male rats were randomly divided into seven groups (n = 5). Diabetes mellitus was induced in groups 2–7 via a single intraperitoneal injection of streptozotocin (STZ; 55mg/kg). Group 1(DW) received distilled water (2mL/kg) only. Group 2 (STZ; untreated), group 3 {MET; metformin (Glucophage)}, group 4 {HS; Hibiscus sabdariffa (400mg/kg)}, group 5 {DAF; daflon-500® (1000mg/kg)}, group 6 {DAF+HS; daflon-500® (1000mg/kg) and Hibiscus sabdariffa (400mg/kg)}, group 7 {DAF+MET+HS; daflon-500® (1000mg/kg), metformin (Glucophage), and Hibiscus sabdariffa (400mg/kg)}. Body weight and blood glucose were assessed fortnightly. Blood and hepatic/pancreatic tissues were collected for hematological and antioxidant testing. Results: Groups 2–7 revealed a significant (P < 0.05) decrease in body weight on day 14 compared to the increased growth rate observed on day 28 (Group 7).Blood glucose levels significantly increased on days 1 and 14 in groups 2–7 but declined on day 28 in groups 4–7. Significantly higher packed cell volume, hemoglobin levels, red blood cell counts, lymphocytes, and mean corpuscular hemoglobin were observed in groups 5–7. Platelet counts were higher in Groups 2 and 5. Untreated group 2 exhibited considerably reduced catalase activity, glutathione, and malondialdehyde concentrations compared to the treated groups. Conclusion: Hibiscus sabdariffa linn and Daflon-500® expressed substantial hypoglycemic, antioxidant, and hemato-protective effects.http://www.sciencedirect.com/science/article/pii/S2667031324001738Diabetes mellitusBody weightBlood glucoseOxidative stressDaflon-500®Hibiscus sabdariffa |
| spellingShingle | Aishat Omobolanle Olatunji Root Oluwapelumi Alegbe Suleiman Folorunsho Ambali Muftau Shittu Ganiu Jimoh Akorede Abdulfatai Aremu Afisu Basiru Jamila Abdulhamid Atata Kolawole Yusuf Suleiman Charles Amoto Shuaibu Co-administration of Hibiscus sabdariffa linn and Daflon-500® mitigates weight loss, hyperglycemia, hematological and oxidative changes in male rats with type-2 diabetes Phytomedicine Plus Diabetes mellitus Body weight Blood glucose Oxidative stress Daflon-500® Hibiscus sabdariffa |
| title | Co-administration of Hibiscus sabdariffa linn and Daflon-500® mitigates weight loss, hyperglycemia, hematological and oxidative changes in male rats with type-2 diabetes |
| title_full | Co-administration of Hibiscus sabdariffa linn and Daflon-500® mitigates weight loss, hyperglycemia, hematological and oxidative changes in male rats with type-2 diabetes |
| title_fullStr | Co-administration of Hibiscus sabdariffa linn and Daflon-500® mitigates weight loss, hyperglycemia, hematological and oxidative changes in male rats with type-2 diabetes |
| title_full_unstemmed | Co-administration of Hibiscus sabdariffa linn and Daflon-500® mitigates weight loss, hyperglycemia, hematological and oxidative changes in male rats with type-2 diabetes |
| title_short | Co-administration of Hibiscus sabdariffa linn and Daflon-500® mitigates weight loss, hyperglycemia, hematological and oxidative changes in male rats with type-2 diabetes |
| title_sort | co administration of hibiscus sabdariffa linn and daflon 500 r mitigates weight loss hyperglycemia hematological and oxidative changes in male rats with type 2 diabetes |
| topic | Diabetes mellitus Body weight Blood glucose Oxidative stress Daflon-500® Hibiscus sabdariffa |
| url | http://www.sciencedirect.com/science/article/pii/S2667031324001738 |
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