Prognostic impact of systemic inflammation indicators on all-cause and CVD mortality in adults with MASLD
Abstract Background Inflammation plays a key role in the onset of MASLD, progression to MASH, and is associated with poor prognosis of MASLD. The aim of this study was to thoroughly investigate the association of different systemic inflammatory indicators with all-cause mortality and CVD mortality o...
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BMC
2025-07-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-04018-3 |
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| author | Yaqiong Wang Kuangyang Chen Jie Yu Yifan Tu Yuxin Zhao Yikai Zhang Yepeng Hu Hong Yang Han Yan Chao Zheng |
| author_facet | Yaqiong Wang Kuangyang Chen Jie Yu Yifan Tu Yuxin Zhao Yikai Zhang Yepeng Hu Hong Yang Han Yan Chao Zheng |
| author_sort | Yaqiong Wang |
| collection | DOAJ |
| description | Abstract Background Inflammation plays a key role in the onset of MASLD, progression to MASH, and is associated with poor prognosis of MASLD. The aim of this study was to thoroughly investigate the association of different systemic inflammatory indicators with all-cause mortality and CVD mortality outcome in MASLD. Methods Data were from the NHANES cohort. Mortality data were from the NDI. Systemic inflammatory indicators analyzed included lymphocytes, monocytes, neutrophils, platelets, CRP, MLR, NLR, and PLR. Associations of inflammatory indicators with mortality were analyzed using Kaplan-Meier curves, Cox regression, and restricted cubic spline analysis. Time-dependent ROC curve was performed to analysis the predictive value of inflammatory indicators for mortality. Results 10,308 MASLD adults were included. Systemic inflammatory markers were associated with mortality outcome in MASLD. Specifically, lymphocyte and platelet count showed an L-shaped association with all-cause mortality in MASLD patients, monocyte and neutrophil count and CRP level demonstrated a positive nonlinear correlation, NLR and MLR presented a linear positive correlation, and PLR presented a U-shaped association (all P < 0.001). Time-dependent ROC curve analysis showed that NLR and MLR exhibited higher predictive values among all these markers for mortality in MASLD adults. Conclusions Systemic inflammatory indicators were associated with mortality outcome in MASLD and may serve as valuable prognostic biomarkers for MASLD. |
| format | Article |
| id | doaj-art-ce7aa03ff28c44a4a525367df67658a0 |
| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | BMC Gastroenterology |
| spelling | doaj-art-ce7aa03ff28c44a4a525367df67658a02025-08-20T03:45:32ZengBMCBMC Gastroenterology1471-230X2025-07-0125111410.1186/s12876-025-04018-3Prognostic impact of systemic inflammation indicators on all-cause and CVD mortality in adults with MASLDYaqiong Wang0Kuangyang Chen1Jie Yu2Yifan Tu3Yuxin Zhao4Yikai Zhang5Yepeng Hu6Hong Yang7Han Yan8Chao Zheng9Department of Endocrinology, The Second Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Endocrinology, The Second Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Endocrinology, The Second Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Endocrinology, The Second Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Endocrinology, The Second Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Endocrinology, The Second Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Endocrinology, The Second Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Endocrinology, The 3rd Affiliated Hospital of Wenzhou Medical University, Ruian People’s HospitalDepartment of Endocrinology, The Second Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Endocrinology, The Second Affiliated Hospital, School of Medicine, Zhejiang UniversityAbstract Background Inflammation plays a key role in the onset of MASLD, progression to MASH, and is associated with poor prognosis of MASLD. The aim of this study was to thoroughly investigate the association of different systemic inflammatory indicators with all-cause mortality and CVD mortality outcome in MASLD. Methods Data were from the NHANES cohort. Mortality data were from the NDI. Systemic inflammatory indicators analyzed included lymphocytes, monocytes, neutrophils, platelets, CRP, MLR, NLR, and PLR. Associations of inflammatory indicators with mortality were analyzed using Kaplan-Meier curves, Cox regression, and restricted cubic spline analysis. Time-dependent ROC curve was performed to analysis the predictive value of inflammatory indicators for mortality. Results 10,308 MASLD adults were included. Systemic inflammatory markers were associated with mortality outcome in MASLD. Specifically, lymphocyte and platelet count showed an L-shaped association with all-cause mortality in MASLD patients, monocyte and neutrophil count and CRP level demonstrated a positive nonlinear correlation, NLR and MLR presented a linear positive correlation, and PLR presented a U-shaped association (all P < 0.001). Time-dependent ROC curve analysis showed that NLR and MLR exhibited higher predictive values among all these markers for mortality in MASLD adults. Conclusions Systemic inflammatory indicators were associated with mortality outcome in MASLD and may serve as valuable prognostic biomarkers for MASLD.https://doi.org/10.1186/s12876-025-04018-3MASLDSystemic inflammationPrognosisAll-cause mortalityCVD mortality |
| spellingShingle | Yaqiong Wang Kuangyang Chen Jie Yu Yifan Tu Yuxin Zhao Yikai Zhang Yepeng Hu Hong Yang Han Yan Chao Zheng Prognostic impact of systemic inflammation indicators on all-cause and CVD mortality in adults with MASLD BMC Gastroenterology MASLD Systemic inflammation Prognosis All-cause mortality CVD mortality |
| title | Prognostic impact of systemic inflammation indicators on all-cause and CVD mortality in adults with MASLD |
| title_full | Prognostic impact of systemic inflammation indicators on all-cause and CVD mortality in adults with MASLD |
| title_fullStr | Prognostic impact of systemic inflammation indicators on all-cause and CVD mortality in adults with MASLD |
| title_full_unstemmed | Prognostic impact of systemic inflammation indicators on all-cause and CVD mortality in adults with MASLD |
| title_short | Prognostic impact of systemic inflammation indicators on all-cause and CVD mortality in adults with MASLD |
| title_sort | prognostic impact of systemic inflammation indicators on all cause and cvd mortality in adults with masld |
| topic | MASLD Systemic inflammation Prognosis All-cause mortality CVD mortality |
| url | https://doi.org/10.1186/s12876-025-04018-3 |
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